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WAO Medical Book Review

Posted: April 2014

Bronchial Asthma – Emerging Therapeutic Strategies
Edited by Edited by Elizabeth Sapey
Online Edition Published by InTech on 29 February 2012
ISBN: 978-953-51-0140-6
DOI: 10.1007/978-1-4614-7261-2
DOI: 10.5772/1077
InTech Copyright Policy
Published under the Creative Commons Attribution 3.0 Unported (CC BY 3.0 License)

Retail Price: Free, Open Access for Online Edition
Available from: InTech

Delara Babaie, MD
Assistant Professor of Allergy and Clinical Immunology
Mofid Children’s Hospital
Tehran, Iran

Asthma is a clinical syndrome with no single test to confirm its presence. It is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. It has been estimated that at least 300 million people worldwide live with asthma, with a predicted 100 million additional cases appearing by 2025. Asthma represents 1% of the total global disease burden, and the healthcare costs related to asthma (directly or indirectly) is steadily increasing. Age of onset, disease severity and clinical course varies between patient groups, and these clinical phenotypes are likely to reflect differences in the genetic, developmental and environmental factors. Understanding the epigenetics of asthma will shed a new light on treatment strategies.

Despite the effectiveness of current treatment strategies in most patients, none have changed the natural course of the illness; only disease-related symptoms are modified by transiently reducing inflammation. Comprehensive asthma management is not only pharmacological-based; a thoughtful approach to other aspects of disease management is necessary for optimal care. This book contains valuable knowledge regarding asthma biomarkers, immunopathological differences between childhood and adult asthma, diagnostic methods, and therapeutic approach in asthma, which will aid healthcare providers in being completely aware of various options in the diagnosis and management of affected individuals.

The book content is organized into 11 chapters. Chapter number one explains natural history of asthma. The second chapter describes the bronchial challenge tests. It is emphasized that choosing a challenge test depends on patient’s medical background and it may change as new evidence appears. Asthma biomarkers, which were derived from Exhaled Breath Condensate, are discussed in the third chapter. They potentially offer a novel way of monitoring lung inflammation if clinically validated in future studies. Immune mechanisms of childhood asthma and the effect of age on allergic asthma are reviewed in chapters 4 and 5. Association between Airway smooth muscle and asthma phenotypes are discussed in the sixth chapter. Chapter 7 explains the effect of Fluoride on bronchial smooth muscles. Finally, chapters 8 to 11 provide specific information about different aspects of asthma management in children, mechanisms of reduced sensitivity to glucocorticoids, antioxidant strategies, and the most forgotten section, rehabilitation. The main features of this book are gathered in the summary of each chapter.

Assessment and Audience
As a comprehensive overview of the mechanisms, clinical manifestations and diagnostic methods, and the treatment strategies in controlling asthma, this book will provide complete and practical information for physicians, scientists, and other healthcare providers interested in asthma.

Assessment and Audience
This book offers a comprehensive and stimulating, up-to-date review of allergic rhinitis. Allergists and other physicians interested in allergic disease and who deal with patients with AR such as otolaryngologists, pediatricians, and general practitioners may find this book very useful. The book is available in open access format or can be purchased in print form.