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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.

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WAO Medical Book Review

Posted: May 2014

Eosinophilic Esophagitis
Series: Clinical Gastroenterology
Edited by Chris A. Liacouras and Jonathan E. MarKowitz
2012 Springer Science+Business Media, LLC
ISBN: 978-1-60761-514-9 (hardcover)
ISBN 978-1-61779-757-6 (softcover)
eISBN: 978-1-60761-515-6 (digital)

List prices: ebook $219.00 Hard cover $279.00 Soft cover $279.00
Available from: Springer

Reviewer
Zeinab A El-Sayed, MD, PhD
Pediatric Allergy and Immunlogy Unit, Children's Hospital
Ain Shams University, Cairo, Egypt.

Description
Once believed to possibly represent recalcitrant gastroesophageal reflux disorder, eosinophilic esophagitis (EoE) is now known to be a unique entity with a specific transcriptional signature, epidemiologic descriptors, histologic features, and treatments.

The estimated pediatric disease prevalence at 50 per 100,000 ranks EoE as more commonly encountered in clinical practice than other gastroenterologic disease entities such as biliary atresia and inflammatory bowel disease. In adults, the diagnostic delay of 4.2 years on average is partly attributed to unawareness of sentinel features at endoscopy.

Purpose
Ever since its identification as a disorder in 1995, EoE has gained much attention. Working and research groups have been developed to provide cohesive guidelines on the definition, diagnosis, and therapy of EoE, such as the FIGERS, which coined a consensus statement in 2007, and the TIGERS, which worked on searching for a genetic basis for EoE. Accordingly, reports in the literature have grown tremendously. The current book offers an invaluable assortment of these reports which are presented in very well-structured reviews.

Features
The book, Eosinophilic Esophagitis, encompasses the historical literature as well as the up-to-date knowledge on the subject. Experts as they are in the field, based on their clinical and research experience and their long-standing dedication, the contributing authors have written 31 informative chapters with a great depth of knowledge on all aspects of the disorder addressing both the pediatric and the adult perspectives. The content covers the epidemiology of EoE, its genetic basis, clinical manifestations, radiologic, endoscopic, and histologic diagnoses, its relation to other atopic conditions, and the role of allergy testing, complications. Lastly it covers the different therapeutic modalities including dietary treatment, drugs, biologics, and esophageal dilatation. The psychologic aspect of EoE is also tackled.

In the context of the book the reader can find answers to the questions of how the esophagus is an immunological organ not just a food conduit, and whether EoE is a truly new or only newly recognized disease, more prevalent or more recognized, and seasonal or perennial, as well as the top ten food triggers. The book contains numerous illustrative figures and tables and provides informative summary points at the end of the chapters.

Assessment and Audience
The cumulative knowledge presented in the book provides a comprehensive review on the subject of EoE, opens new horizons for research, and suggests novel potential therapeutic targets for this disorder. Providing useful practical information, this book will be of great value to gastroenterologists, allergologists, pediatricians, internists, pathologists, endoscopic surgeons, and fellows, all who deal with EoE patients.