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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.

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WAO Medical Book Review

Cystic Fibrosis in the 21st Century
Bush, A., Alton, EWFW., Davies, JC., Griesenbach, U. & Jaffe, A.
ISBN-10: 3-8055-7960-8
ISBN-13: 978-3-8055-7960-5

List price: $180.00 USD
Available from: Karger

Reviewer: 
Dr RG Stirling BSc(Hons), MBBCh(Hons), MRCPI, FRACP
Department of Allergy Immunology & Respiratory Medicine; Alfred Hospital & Monash University; Melbourne, Australia

Description:    
Recent decades have seen an explosion of knowledge in Cystic Fibrosis (CF), surrounding CFTR structure, function and the mechanism by which this gene defect causes human disease. This book addresses these developments in some detail, yet also broadly scopes a range of current CF-related research activity. Further in-depth consideration is given to the challenge of clinical care in relation to airway infection, inflammation and the management of the extrapulmonary manifestations of CF.

Purpose:         
A state of the art overview of recent advances in Cystic Fibrosis.

Audience:       
This volume is largely aimed at researchers and clinicians established in CF, needing to update and broaden their understanding of CF.

Features:        
This book acknowledges the multidisciplinary approach necessary for advancing CF care by blending a strong scientific base to the broad clinical needs of the CF population. Edited and written by leading figures in CF research, this volume highlights developments in understanding of CFTR structure and function, yet provides useful updates in the key management and therapeutic questions for pediatric and to a lesser degree adult CF care.

Assessment:    
This volume places substantial emphasis in the description of current knowledge of CFTR structure, function and their interrelationships. The interactions and significance of genotype, modifier genes, infection and inflammation provide many complex challenges to our understanding of CF, and this book also provides a broad yet succinct research update in a number of these areas. For the practicing clinician, however, CF in the 21st century is evolving as a disease of adulthood and many emerging adult medical issues including bone disease, GORD, non-invasive ventilation and the complex management challenges of airway clearance, psychosocial counselling, ethics, transition, palliation and transplantation, require further attention. Nevertheless, this volume provides a valuable supplement and addition for those seeking to update and broaden their understanding of Cystic Fibrosis.