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WAO Medical Book Review

Applying Genomic and Proteomic Microarray Technology in Drug Discovery
Robert S. Matson
CRC Press, ISBN 0-8493-1469-0

List price: $119.95
Available from: CRC Press

Reviewer: Gary Hellermann
University of South Florida College of Medicine, Tampa, Florida

We hear a lot about microarrays as research and diagnostic tools, but they are also utilized in the search for new drugs. Microarrays generate a picture of the molecular processes in a specific cell or tissue and this unique window allows drug researchers to directly see the effects of a test agent. Microarrays are one of those enabling technologies, like the polymerase chain reaction, that open a vast realm of possibilities in medical diagnostics and drug development, and this book provides a comprehensive and practical text for this exciting new field.

The purpose of this book is to provide a thorough understanding of the technology of microarrays and to evaluate their usefulness in developing new approaches to biomedical problem-solving.

Scientists and pharmaceutical researchers, bioinformaticians and technologists, students and teachers will all find this book a helpful source of information about a field that is rapidly becoming one of the mainstays of medicine now and in the future.

The book's 243 pages are divided into six chapters that cover the history, technology and application of DNA and protein microarrays. Each chapter has pertinent references for additional study in specific areas. The chapters are especially well illustrated with diagrams, photos, tables and graphs that highlight the important points and enhance understanding of the text. DNA microarrays are the best-studied system, but protein-based arrays are strong contenders for new uses along with other array types employing antibodies, carbohydrates, small molecules and even cells and tissues. Uses in clinical trials, prediction, diagnosis, prognosis and treatment are practically limitless.