Marc E. Rothenberg, MD, PhD
Cincinnati Children's Hospital
Professor of Pediatrics
Director, Division of Allergy and Immunology
Director, Cincinnati Center for Eosinophilic Disorders
Cincinnati, Ohio, USA
Eosinophilic Esophagitis is a chronic allergic inflammatory disorder of the esophagus that is compounded by both genetic predisposition and aberrant responses to environmental antigens, particularly those derived from food. Recent advances in understanding the intrinsic (genetic) and extrinsic (environmental) components and the key molecular pathways and antigenic triggers illustrate the complex nature of this emerging disease. Expression profiling of mRNA and microRNA transcripts, as well as whole genome analysis of high-density genetic variants, have identified key etiological steps that provide novel insight into disease mechanisms and entry points for therapeutic strategies. Emerging data demonstrate the interplay of epithelial cells, mast cells and eosinophils, Th2-associated cytokines including IL-13 and TSLP, as well as acquired and inherited impairment of barrier function.