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April Medical Journal Review
四月世界医学杂志回顾
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April World Medical Journal Review

四月世界医学杂志回顾

Prof. Richard F. Lockey, MD, WAO Web Editor-in-Chief, reviewed premier April medical journal articles for practicing allergists.
Richard F. Lockey教授,医学博士,WAO网站主编,他为在业的变态反应科医生回顾了四月医学杂志的一些重要文章。

1. INCREASED GLUCOCORTICOID RECEPTOR ß ALTERS STEROID RESPONSE IN GLUCOCORTICOID-INSENSITIVE ASTHMA
BAL cells of 7 patients with glucocorticoid (GC)-sensitive asthma and 8 patients with GC-insensitive asthma were examined to define the functional role of glucocorticoid receptor (GCR) ß (a splicing variant and dominant negative inhibitor of the classic GCRa) in controlling GCRa nuclear translocation and transactivation at a molecular level. Significantly reduced nuclear translocation of GCRa in response to GC was present in GC-insensitive asthma. These same subjects had significantly increased levels of cytoplasmic and nuclear GCRß. RNA silencing of GCRß mRNA in BAL macrophages from these same subjects enhanced dexamethasone-induced GCRa transactivation. Editor's comment: Measurable differences in GC receptor activity are present in GC-insensitive asthma. Goleva E, et al. Am J Respir Crit Care Med 2006; 173: 607.
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1. 糖皮质激素不敏感的哮喘患者中糖皮质激素受体β的增加能改变对激素的反应性
分 别收集7例糖皮质激素敏感哮喘患者和8例激素不敏感哮喘患者的支气管肺泡灌洗液,在分子水平研究糖皮质激素受体(GCR)β(经典GCRa的一种剪接变体 和显性负相抑制物)在控制GCRa核转运和转活中作用。在GC不敏感的哮喘患者中,应用GC治疗后产生的GCRa核转运明显降低。同时在这些患者中,细胞 质和细胞核的GCRβ水平明显增加。同样这些患者,BAL巨噬细胞中GCRβ mRNA沉默会增强地塞米松诱导的GCRa转活。编者按:在GC不敏感哮喘患者中,GC受体活性与其他患者存在可测量的差异。Goleva E, et al. Am J Respir Crit Care Med 2006; 173: 607.

2. THE EFFECT OF TELITHROMYCIN IN ACUTE EXACERBATIONS OF ASTHMA
A total of 278 adults with asthma were enrolled within 24 hours after an acute exacerbation requiring short-term medical care. They were randomly assigned to receive 10 days of oral telithromycin 800 mg daily or placebo in addition to usual care. The primary efficacy end points were a change from baseline over the treatment period in symptoms as recorded by the patient and A.M. peak expiratory flow (PEF). Presence of Chlamydophila pneumoniae or Mycoplasma pneumoniae was assed by the polymerase chain reaction and culture. Patients on telithromycin had a significantly greater reduction of symptoms than those on placebo, but no significant difference in A.M. PEF. Sixty-one percent had evidence of infection with C. pneumoniae, M. pneumoniae or both, but there was no relationship between bacteriologic status and response to asthma treatment. Editor's comment: Are C. pneumoniae and, M. pneumoniae important in the pathogenenesis of asthma? Is the effect of telithromycin antibacterial or anti-inflammatory? Is the response to this antibiotic similar to other macrolides? The debate goes on! Johnston SF, et al. N Engl J Med 2006; 354: 1589. Little FF, (editorial), p.1632.
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2.泰利霉素在哮喘急性发作中的作用
共 有278例急性哮喘发作24小时内,并需短期治疗的成人哮喘患者纳入了这项研究。他们除了接受一般的治疗外,还随机接受10天口服泰利霉素800mg/日 或安慰剂治疗。疗效的主要观察指标是经治疗后患者记录的症状以及早晨的最大呼气流量(PEF)与基线的差值。研究还采用PCR和培养的方法检查是否存在肺 炎衣原体或肺炎支原体。结果发现,泰利霉素治疗组患者的症状缓解程度要明显优于安慰剂组,但两组间的早晨PEF没有明显差异。61%的患者证实存在肺炎衣 原体和/或肺炎支原体的感染,但这种细菌感染状态和哮喘治疗反应之间不存在任何相关性。编者按:肺炎衣原体和肺炎支原体是否在哮喘发病机制起着重要作用?泰利霉素在其中是发挥抗感染作用还是抗炎作用?其它大环内酯类抗生素是否也具有类似这种抗生素的治疗反应?一切还有待研究。Johnston SF, et al. N Engl J Med 2006; 354: 1589. Little FF, (editorial), p.1632.

3. BUILDING HEALTH: AN EPIDEMIOLOGICAL STUDY OF "SICK BUILDING SYNDROME" (SBS)
SBS was studied in a cross sectional data analysis of the physical environment of a selection of buildings added to individual data from the Whitehall II study -- an ongoing health survey of office-based civil servants. A self-report questionnaire was used to capture 10 symptoms of SBS and psychosocial work stress. In total, 4,052 participants, 42-62 yrs, working in 44 buildings were included in the study. Positive, but non-significant, relations were found with airborne bacteria, inhalable dust, dry bulb temperature, relative humidity, and having some control over the local physical environment. Greater effects were found with features of the psychosocial work environment, including high job demands and low support. Only psychosocial work characteristics and control over the physical environment were independently associated with symptoms in the multivariate analysis. Editor's comment: "Sick Building Syndrome" is a misnomer. This syndrome would be better termed "Building Related Complaints." Marmot AF, et al. Occup Environ Med 2006; 63: 283.
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3. 建筑物中的健康状况:关于“有害建筑综合症”(SBS)的流行病学研究
这 项研究的数据来自一项目前正在进行的关于办公室工作的国家公务员健康状况调查,即Whitehall(白厅)Ⅱ期研究,SBS这项横断面调查研究综合分析 了某个选定建筑物的自然环境数据以及其中工作的每个人的数据。研究中采用自我报告问卷调查的方式询问了有关SBS的10个症状以及心理工作压力。共有在 44个建筑物中工作的4,052人(42-62岁)参与了这项研究。结果发现,这些症状和空气中的细菌,可吸入灰尘,干球温度,相对湿度等以及局部自然环 境的控制之间存在阳性的但无显著意义的相关性。而心理社会工作环境方面的因素,包括工作压力大,待遇差则有很大的影响。根据多变量分析结果,只有心理社会 工作因素和自然环境控制措施这两方面和症状独立相关。编者按:“有害建筑综合症”这个名称并不恰当。这些症状最好应称之为“建筑物相关不良症状”。Marmot AF, et al. Occup Environ Med 2006; 63: 283.

4. SAFETY AND IMMUNOGENICITY OF AN INACTIVATED SUBVIRION INFLUENZA A (H5N1) VACCINE.
The authors conducted a multicenter, double-blind, two-stage study involving 451 healthy adults 18-64 yr who were randomly assigned to receive various IM doses of a subvirion influenza A (H5N1) vaccine ("Bird Flu") or placebo. There were no major safety problems and the highest antibody responses were among those subjects who received 45 µg (43 % response) and 90 µg (58% response). Editor's comment: The 58% response is lower than ideal, but good news for a virus which could cause a world-wide flu epidemic. Treanor JJ, et al. N Engl J Med 2006; 345: 1343.
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4. 一种灭活的亚病毒粒子流感(H5N1)疫苗的安全性和免疫原性
这 是一项多中心,双盲,两阶段的研究,共有451例年龄在18-64岁的健康成人随机接受了不同IM剂量的亚病毒粒子流感(H5N1)疫苗(“禽流感”)或 安慰剂注射。研究未发现重要的安全问题,在所有受试者中,接受45 µg(43%应答)和90 µg(58%应答)个体的获得了最高的抗体应答水平。编者按:尽管58%的应答水平不够理想,但对于一种能导致全球流感流行的病毒来说也算是个好消息。Treanor JJ, et al. N Engl J Med 2006; 345: 1343.

5. NEUROPSYCHOLOGICAL AND RENAL EFFECTS OF DENTAL AMALGAM IN CHILDREN and NEUROBEHAVIORAL EFFECTS OF DENTAL AMALGAM IN CHILDREN
Both studies are randomized clinical trials. The first study compares neuropsychological and renal function of children (6 to 10 yrs at baseline) whose dental caries were restored using amalgam or mercury free materials. The second study assesses the safety of dental amalgam vs. resin composite restorations in children, (8 to 10 yrs at baseline). The first study followed patients for 5 yrs and the second for 7 yrs. Both conclude that dental amalgam is safe and does not affect neuropsychological outcomes, renal disease or have any adverse neurobehavioral effects. Editor's comment: This paper concludes that amalgam restorations are safe! Bellinger DC, et al. JAMA 2006; 295: 1775. DeRouen TA, et al. p. 1784.
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5. 牙科汞合金对儿童神经心理学和肾脏功能的影响,牙科汞合金对儿童神经行为的影响
这 两项研究都是随机临床试验。第一个研究比较了儿童(基线年龄为6-10岁)龋齿用汞合金或无汞材料修复后的神经心理学和肾脏功能。第二个研究分别评估了儿 童(基线年龄为8-10岁)采用牙科汞合金和树脂复合物进行修复的安全性。第一项研究随访了5年,第二项随访了7年。这两项研究均得出了以下结论,牙科汞 合金是安全的,不会对儿童的神经心理学造成影响,也不会造成肾脏疾病和任何不良的神经行为影响。编者按:这篇文章说明采用汞合金重建是安全的。Bellinger DC, et al. JAMA 2006; 295: 1775. DeRouen TA, et al. p. 1784

6. A META-ANALYSIS OF THE EFFECT OF HIGH WEIGHT ON ASTHMA
A Medline search (1966 to October, 2004), supplemented by a manual search of reference lists and literature, was used for this meta-analysis cohort study that examined high body weight at birth or during childhood and future asthma. The combined results from 4 studies that met inclusion criteria and examined the effect of high body weight during middle childhood on the outcomes of subsequent asthma showed a 50% increase in relative risk (RR 1.5, 95% CI 1.2 to 1.8). The combined results from 9 studies that examined the effect of high birth weight on subsequent asthma had a pooled RR of 1.2 (95% CL 1.1 to 1.3). There was consistency among the studies. Editor's comment: Excessive weight affects many diseases, including asthma. Flaherman V, Rutherford GW. Arch Dis Child 2006; 91: 334.
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6. 肥胖对哮喘影响的一个荟萃分析

这 项荟萃分析的人群研究是采用Medline检索(1966至2004年10月)并辅助手工检索参考文献和著作的方法进行的,作者调查了出生时或儿童期体重 过大对以后哮喘的影响。共有4项研究符合入选标准,综合分析结果显示,儿童中期体重过大导致以后出现哮喘的相对危险性增加50%(RR 1.5, 95% CI 1.2至1.8)。综合分析9项研究的结果显示,高出生体重导致以后出现哮喘的混合相对危险度是1.2(95% CI 1.1至1.3)。所有这些研究得出的结论都是一致的。编者按:肥胖会影响很多疾病,包括哮喘。Flaherman V, Rutherford GW. Arch Dis Child 2006; 91: 334.

7. DOES ANTIBIOTIC EXPOSURE DURING INFANCY LEAD TO DEVELOPMENT OF ASTHMA? A SYSTEMATIC REVIEW AND META-ANALYSIS?
Eight studies (four prospective and four retrospective) examined the association between exposure to at least one course of antibiotics and development of childhood asthma. The authors conclude that exposure to at least one course of antibiotics during the first year of life seems to be a risk factor for childhood asthma. Likewise, there is a slight dose-response association for each additional course of antibiotics. Editor's comment: Conclusions from this study are consistent with the "hygiene hypothesis." Marra F, et al. Chest 2006; 129: 610.
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7.婴儿期暴露于抗生素是否导致哮喘的发生?一个系统性的综述和荟萃分析?
共有8项研究(4项是前瞻性的,4项是回顾性的)调查了至少一个疗程的抗生素暴露史和发生儿童哮喘之间的联系。作者结论指出,在出生一岁以内存在至少一个疗程的抗生素暴露史是发生儿童哮喘的一个危险因素。同时,随着抗生素疗程的增加,还存在一种轻度的量效关系。编者按:这项研究的结论符合“卫生学假说”。Marra F, et al. Chest 2006; 129:

8. AN EXCELLENT REVIEW ON SEVERE ASTHMA
Asthma is the theme of this issue of the JACI. Articles include: Severe Asthma: An Overview; Understanding the Pathophysiology of Severe Asthma to Generate New Therapeutic Opportunities; Managing Severe Asthma; Severity and Control of Severe Asthma; Update on Glucocorticoid Action and Resistance; Severity, Control, and Responsiveness in Asthma; and Severe asthma. Editor's comment: Although there is some redundancy, these are excellent reviews about the pathophysiology and treatment of severe asthma. Moore WC et al, p-487; Holgate ST et al, p-496; Wenzel S, Szefler SJ, p-508; Bateman ED, p-519; Ito K, et al, p-522; Stoloff SW, Boushey HA, p-544; Foley S, Hamid Q, p-714. J Allergy Clin Immunol 2006; 117:
Severe Asthma: An Overview
Understanding the Pathophysiology of Severe Asthma to Generate New Therapeutic Opportunities
Managing Severe Asthma: No abstract is available.
Severity and Control of Severe Asthma: No abstract is available.
Update on Glucocorticoid Action and Resistance
Severity, Control, and Responsiveness in Asthma
Severe asthma: No abstract is available.
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8. 关于重症哮喘的一些优秀的综述
哮喘是本期JACI杂志的主题。文章包括:重症哮喘:概述;根据重症哮喘病理生理学知识产生的新的治疗机遇;重症哮喘的管理;重症哮喘的严重性和控制措施;糖皮质激素作用和激素抵抗的新进展;哮喘的严重性分级,控制措施和治疗反应性;重症哮喘。编者按:尽管有些文章的内容是重复的,但总体来说,这些关于重症哮喘病理生理学和治疗的综述还是很优秀的。Moore WC et al, p-487; Holgate ST et al, p-496; Wenzel S, Szefler SJ, p-508; Bateman ED, p-519; Ito K, et al, p-522; Stoloff SW, Boushey HA, p-544; Foley S, Hamid Q, p-714. J Allergy Clin Immunol 2006; 117:
重症哮喘:概述
根据重症哮喘病理生理学知识产生的新的治疗机遇
重症哮喘的管理:本文没有提供摘要。
重症哮喘的严重性和控制措施:本文没有提供摘要。
糖皮质激素作用和激素抵抗的新进展
哮喘的严重性分级,控制措施和治疗反应性
重症哮喘:本文没有提供摘要。

9. INTERESTING COLLECTION OF REVIEW ARTICLES ON DRUG ALLERGY
These articles include: Drug-Induced Hypersensitivity Syndrome (DIHS): A Reaction Induced by a Complex Interplay Among Herpesviruses and Antiviral and Antidrug Immune Responses; Toxic Epidermal Necrolysis and Stevens Johnson Syndrome: Our Current Understanding; Pharmacological Interaction of Drugs with Immune Receptors: The p-i Concept; Immune Mechanisms in Drug Allergy; and Recent Advances in the Development of Anti-allergic Drugs. Editor's comment: Progress is being made to better understand the complexity and pathogenesis of drug allergy. Shiohara T, et al, p-1; French LE, p-9; Pichler WJ, et al, p-17; Roujeau J, p-27; Nagai H, et al, p-35. Allergology International 2006; 55.
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9. 一些令人感兴趣的关于药物过敏的综述
这 些文章包括:药物诱导的超敏反应综合症(DIHS):疱疹病毒和抗病毒抗药物免疫应答之间复杂相互作用诱导的一种反应;中毒性表皮坏死溶解和 Stevens Johnson综合症:当前最新认识;药物和免疫受体间的药理学交互作用:p-i概念;药物过敏的免疫学机制;抗变态反应药物研发的新进展。编者按:人们对于药物过敏的复杂性及其发病机制的研究已取得不小的进展。Shiohara T, et al, p-1; French LE, p-9; Pichler WJ, et al, p-17; Roujeau J, p-27; Nagai H, et al, p-35. Allergology International 2006; 55.

10. ANTIINFLAMMATORY EFFECTS OF SALMETEROL/FLUTICASONE PROPIONATE IN COPD
Bronchial biopsies and induced sputum were collected from 140 current and former smokers (mean age, 64 yr) with moderate to severe COPD. They were randomized in a 13-wk, double-blind study to placebo or salmeterol/fluticasone propionate 50/500 µg (n = 67) twice daily. Biopsies were repeated at 12-wk. and sputa at 8- and 13-wk. Combination therapy was associated with a reduction in biopsy CD8+ cells, not CD68+ cells. Sputum differential (but not total) neutrophils reduced progressively. The combination also significantly reduced biopsy CD45+ and CD4+ cells, cells expressing genes for tumor necrosis factor–a and IFN-? and sputum total eosinophils. Changes were accompanied by a 173-ml improvement in prebronchodilator FEV1. Editor's comment: The combination of salmeterol/fluticasone are anti-inflammatory for COPD. Barnes NC, et al. Am J Respir Crit Care Med 2006; 173: 736.
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10. 沙美特罗/丙酸氟替卡松在COPD中的抗炎作用<
研 究选取了140例正在吸烟和曾经吸烟的中重度COPD患者(平均年龄64岁)进行随机双盲研究,分别给予一天两次的安慰剂或沙美特罗/丙酸氟替卡松 50/500 µg (n = 67)治疗,疗程持续13周。治疗前先进行支气管活检和诱导痰分析,然后在治疗的12周重复支气管活检,第8和第13周重复痰液分析。联合治疗组活检结果 示CD8+细胞减少,而CD68+细胞无变化。痰液中的中性粒细胞逐步减少(但并非全部)。联合治疗同时也能明显降低活检组织中的CD45+和 CD4+细胞,减少表达肿瘤坏死因子-α和IFN-γ基因的细胞数量,并能减少痰液中的嗜酸性粒细胞总数。除了以上这些变化外,联合治疗组还能提高使用支 气管扩张剂前测定的FEV1达173-ml。 编者按:在COPD中,沙美特罗/丙酸氟替卡松联合治疗具有抗炎作用。Barnes NC, et al. Am J Respir Crit Care Med 2006; 173: 736.

11. REVIEW ARTICLE ON EXTRAPULMONARY EFFECTS OF INHALED NITRIC OXIDE: MECHANISMS AND IMPLICATIONS.
These articles include: The Biological Chemistry of Nitric Oxide as It Pertains to the Extrapulmonary Effects of Inhaled Nitric Oxide; Extrapulmonary Effects of Inhaled Nitric Oxide: Role of Reversible S-Nitrosylation of Erythrocytic Hemoglobin; Immunoregulatory and Antimicrobial Effects of Nitrogen Oxides; Regulation of Respiration and Endothelial Gene Expression by S-Nitrosothiols in Health and Disease; and Summary: Systemic Effects of Inhaled Nitric Oxide. Editor's comment: This is an excellent review on the extrapulmonary effects of inhaled nitric oxide. Gow AJ, p-150; McMahon TJ, Doctor A, p-153; Mannick JB, p-161; Palmer LA, p-166; Gaston B, p-170. Proc Am Thorac Soc 2006; 3.
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11. 关于吸入氧化亚氮的肺外效应的综述:作用机制和意义
这 些文章包括:与吸入氧化亚氮肺外效应有关的氧化亚氮的生物化学特性;吸入氧化亚氮肺外效应:红细胞血红蛋白可逆性的S-亚硝基化的作用机制;氮氧化物的免 疫调节和抗微生物作用;S-亚硝基硫醇分别对健康人和患者的呼吸及上皮基因表达的调节作用;总结:吸入氧化亚氮的全身效应。编者按:这是一篇关于吸入氧化亚氮肺外效应的优秀综述。Gow AJ, p-150; McMahon TJ, Doctor A, p-153; Mannick JB, p-161; Palmer LA, p-166; Gaston B, p-170. Proc Am Thorac Soc 2006; 3.


WAO Member Society Spotlight – Latin American Society of Allergy, Asthma and Immunology (SLAAI)

聚焦WAO成员:拉丁美洲变态反应,哮喘和免疫学会(SLAAI)

The Latin American Society of Allergy, Asthma and Immunology (SLAAI) is a non-profit organization that includes 19 National Societies from Latin America and the Iberian Peninsula (Spain and Portugal).
拉丁美洲变态反应,哮喘和免疫学会(SLAAI)是一个非盈利性的组织,她包括了来自拉丁美洲和伊伯利亚半岛(西班牙和葡萄牙)的19个国家的学会。

This year the Latin American Society of Allergy, Asthma and Immunology (LASAAI) will celebrate its 45th anniversary during the XIV Latin American Congress of Allergy, Asthma and Immunology (LACAAI). The LACAAI will be held on 17 – 20 August 2006 in Buenos Aires, Argentina, in collaboration with the XIX Congress of the Argentinean Allergy and Clinical Immunology Association (AACIA). This congress will be the greatest ever scientific meeting in Latin America. The expected attendance is 2,500 participants from not only the region but also from other parts of the world. Spanish is the official language of the congress although many of the sessions will be in English and simultaneous translation into Spanish will be provided.
今年,在即将举办的第十四届拉丁美洲变态反应,哮喘和免疫学会议(LACAAI)上将庆祝拉丁美洲变态反应,哮喘和免疫学会(LASAAI)成立45周 年。本届LACAAI将于2006年8月17-20在阿根廷布宜诺斯艾利斯市举办,同时本次会议也是第十九届阿根廷变态反应和临床免疫学会议 (AACIA)。本次会议将是在拉丁美洲举办的学术会议中最盛大的一届。预计将有来自本地区和世界其它地区的2,500位代表参加此次会议。会议采用西班 牙语作为官方语言,但也有很多分组会议会使用英语,届时会议会提供西班牙语的同声翻译。

The prevalence of asthma and other allergic disorders is very high in Latin America and is a substantial public health problem; therefore an updated program on allergic disorders for allergy specialists and also for general practictioners, pediatricians, and family doctors is needed. There is a high global burden of allergy and other related disorders, however, regional aspects will be also addressed.
在拉丁美洲,哮喘和其它过敏反应性疾病的患病率非常高,是一个很重要的公共卫生问题;因此有必要为变态反应专科医生以及全科医生,儿科医生和家庭医生介绍 一些最新的相关知识。对于全球而言,变态反应和其它相关疾病都是一个很沉重的负担,同时这些疾病还具有一些区域性的特点。

The Scientific Program Committee chaired by Prof. Carlos E. Baena-Cagnani has developed an excellent scientific program that includes discussion on sensitization to universal and regional allergens and specific genetic and environmental factors associated with asthma and atopy in Latin American populations. The following programs will take place during the congress:
由Carlos E. Baena-Cagnani教授负责的学术计划委员会已经设立了很多卓有成效的学术项目,包括对常见和区域性过敏原致敏的讨论,以及拉丁美洲人群中哮喘和特应性有关的特异性遗传和环境因素的研究。在本次会议上将开展以下一些教育项目。

  • WAO/ACAAI ESP: World Allergy Organization - Emerging Societies Program
  • WAO GLORIA Symposium (Global Resources in Allergy) 
  • Global Asthma Patients and Physician survey (GAPP)
  • American College of Allergy Asthma and Immunology
  • 1st Argentinean and Latin American Meeting of Pediatric Allergy, Asthma & Immunology
  • WAO/ACAAI ESP:世界变态反应组织 - 新学会计划
  • WAO GLORIA专题会(变态反应全球资源)
  • 全球哮喘患者和医生调查(GAPP)
  • 美国变态反应哮喘和免疫学会
  • 第一届阿根廷和拉丁美洲国家儿童变态反应、哮喘和免疫学会议

Buenos Aires is the cultural capital of South America. There are many exciting places to visit while you are in Buenos Aires, and the official travel agency has prepared optional tours before and after the congress to unforgettable places such as Iguazu falls, Tierra del Fuego or Perito Moreno Glacier. The incomparably competitive prices for international luxury hotels, restaurants and shopping centers offer an additional attraction to make plans to attend the 14th LACAAI in August 2006.
布宜诺斯艾利斯市是南美洲的文化之都。有很多著名的景点值得大家去游览,在本次会议开始前后,我们还联系了正式旅行社组织了多条特色线路,包括 Iguazu瀑布,Tierra del Fuego或Perito Moreno冰川等,各位代表可以任意选择。此外,布宜诺斯艾利斯市的国际豪华酒店,餐厅和购物中心的优质低价是世界闻名的,在此我们热忱欢迎各位学者参 加于2006年8月举办的第十四届LACAAI会议。

Additional Information:
LACAI Congress web site: http://www.slaai.org/congreso/
AACIA: www.alergia.org.ar/jornadas
E-mail: latamcong@alergia.org.ar
Moreno 909 (C1091AAS)
Ciudad de Buenos Aires, Argentina
Tel. / Fax: (54-11) 4334-7680 / 4331-7356
附注:
LACAI 会议网址: http://www.slaai.org/congreso/
AACIA: www.alergia.org.ar/jornadas
E-mail: latamcong@alergia.org.ar
Moreno 909 (C1091AAS)
阿根廷,Ciudad de Buenos Aires
电话 / 传真: (54-11) 4334-7680 / 4331-7356


WAO Now: What's New in the World of WAO

今日WAOWAO领域新进展

A new synopsis on the Asprin Triad, authored by an international expert in this area, is posted on the WAO Web site this month. To read the latest views on this complex clinical problem, click here.
本月在WAO的网站上,我们上传了一份由国际知名专家讲述的关于阿司匹林三联征的最新简介。如需详细了解阿司匹林三联征这一临床上很复杂的问题,请点击此处

World Allergy Forum
世界变态反应论坛

The diagnosis and management of anaphylaxis is a major concern for allergists worldwide. Anaphylaxis has been selected as the topic for the next World Allergy Forum Symposium scheduled for Sunday, 11 June 2006 - 13:30 – 15:15, during the European Academy of Allergology and Clinical Immunology (EAACI), Annual Scientific Meeting, Vienna, Austria.
对于全世界的变态反应学家而言,诊断和管理严重过敏反应是一个非常值得关注的问题。因此,在奥地利维也纳举办欧洲变态反应和临床免疫学年会期间,即在 2006年6月11日(星期日)13:30 – 15:15开展的新一届世界变态反应学家论坛讨论会,将把严重过敏反应作为会议的主题。

Michael A. Kaliner, President, WAO and Anthony J. Frew, EAACI President, will chair the program of renowned international speakers.
本次论坛将邀请一些国际知名讲者,并由WAO主席Michael A. Kaliner和EAACI主席Anthony J. Frew共同主持。

Life-Threatening Allergy – An Homage to Von Pirquet
危及生命的变态反应病
- 纪念Von Pirquet教授

Epidemiology of Anaphylaxis
Aziz Sheikh, The University of Edinburgh
Edinburgh, Scotland
严重过敏反应的流行病学

苏格兰爱丁堡
爱丁堡大学,Aziz Sheikh

Mechanisms of Anaphylaxis
Richard F. Lockey, University of South Florida College of Medicine
Tampa, Florida, U.S.A.
严重过敏反应的机制

美国佛罗里达州Tampa市
南佛罗里达大学医学院,Richard F. Lockey

Management of Anaphylaxis
F. Estelle R. Simons, University of Manitoba
严重过敏反应的管理

Manitoba大学,F. Estelle R. Simons

Sign up for On-Line Journal Subscription
在线杂志订阅申请

WAO and Hogrefe & Huber Publishers are offering a limited number of free on-line subscriptions to Allergy & Clinical Immunology International - Journal of the World Allergy Organization for members in developing countries. If you are interested in receiving a complimentary, on-line subscription, please send an e-mail to info@worldallergy.org, noting "Free Journal Subscription" in the subject line, with the following details:

First name
Last name
Postal address
City, State/Province and postal code
Country
E-mail address
Name of Member Society


WAO和Hogrefe & Huber出版公司现为发展中国家的会员提供有限数量的《Allergy & Clinical Immunology International - Journal of the World Allergy Organization》免费在线订阅服务。如果您希望得到这份杂志的免费赠阅的电子版,请给我们发送e-mail至info@worldallergy.org,注意在信件的主题栏写“Free Journal Subscription”,并详细注明以下资料:

名字
姓氏
邮政地址
市,州/省和邮政编码
国家
E-mail地址
成员学会的名称


And In Other News

其他新闻

Allergy Book Review
变态反应学书评

Applying Genomic and Proteomic Microarray Technology in Drug Discovery
Robert S. Matson
CRC Press, ISBN 0-8493-1469-0
基因组学和蛋白质组学微阵列技术在药物研发中的应用
Robert S. Matson
CRC Press, ISBN 0-8493-1469-0

List price: $119.95
Available from: CRC Press
定价: 119.95美元
出售网址:CRC Press

Reviewer: Gary Hellermann
University of South Florida College of Medicine, Tampa, Florida
书评作者:Gary Hellermann
内科学和儿科学助理教授
佛罗里达州,坦帕,南佛罗里达大学医学院

Description:
We hear a lot about microarrays as research and diagnostic tools, but they are also utilized in the search for new drugs. Microarrays generate a picture of the molecular processes in a specific cell or tissue and this unique window allows drug researchers to directly see the effects of a test agent. Microarrays are one of those enabling technologies, like the polymerase chain reaction, that open a vast realm of possibilities in medical diagnostics and drug development, and this book provides a comprehensive and practical text for this exciting new field.
说明:
我们可能已经听说了很多使用微阵列技术作为研究和诊断手段的例子,实际上,在新药研发领域,微阵列技术也大有作为。微阵列技术可以产生一个特定细胞或组织 的分子进程的图像,药物研究人员通过这个独特的窗口可以直接看到某个待测试剂的效应。和多聚酶链式反应一样,微数列也同样是一项开创性的技术,它的发展为 医学诊断和药物研发提供了广阔的空间。本书对这一令人振奋的领域进行了广泛而用实用的介绍。

Purpose:
The purpose of this book is to provide a thorough understanding of the technology of microarrays and to evaluate their usefulness in developing new approaches to biomedical problem-solving.
目的:
本书的目的是通过对微阵列技术进行详细而深入的介绍,评价这项技术在发展新的生物医学问题解决模式方面的价值。

Audience:
Scientists and pharmaceutical researchers, bioinformaticians and technologists, students and teachers will all find this book a helpful source of information about a field that is rapidly becoming one of the mainstays of medicine now and in the future.
读者:
对于科学家、药物研发人员、生物信息学家、工艺学家以及学生和教师而言,本书都是一本很有用的参考书,通过阅读,他们将对这一快速发展的、并将成为当前和今后医学重要支柱的领域有所了解。

Features:
The book's 243 pages are divided into six chapters that cover the history, technology and application of DNA and protein microarrays. Each chapter has pertinent references for additional study in specific areas. The chapters are especially well illustrated with diagrams, photos, tables and graphs that highlight the important points and enhance understanding of the text. DNA microarrays are the best-studied system, but protein-based arrays are strong contenders for new uses along with other array types employing antibodies, carbohydrates, small molecules and even cells and tissues. Uses in clinical trials, prediction, diagnosis, prognosis and treatment are practically limitless.
特色:
本书共分6章,243页,内容包括了微阵列技术的发展史、方法学以及DNA和蛋白质微阵列技术的应用。书中的每一章均附有进一步阅读需要的相应参考资料。 本书中还通过很多简图、照片、表格和图片等强调书中的重点,加深读者的理解程度。目前,DNA微阵列技术是研究相对最为深入的一项技术,而蛋白质微阵列技 术以及其它一些采用抗体、碳水化合物、小分子甚至细胞和组织的微阵列技术则是今后强有力的竞争者。总之,这项技术必将拥有广阔的应用领域,包括临床试验、 预测疾病、诊断和治疗疾病、了解预后等。

Find more allergy book reviews on the WAO Website here.
WAO网站上其它的变态反应学书评见此处

The World Allergy Organization's mission is to build a global alliance of allergy societies to advance excellence in clinical care, research, education and training. Visit us on the Web at http://www.worldallergy.org/

World Allergy Organization (WAO)
Secretariat
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
Email: info@worldallergy.org

You have received this message because you are a member of a WAO Member Society, you have subscribed for the monthly e-letter or had previous contact with the World Allergy Organization. If you would prefer not to receive further messages from WAO, please reply to this message with REMOVE in the subject line.

世界变态反应组织的使命是建立一个全球性的变态反应学会联盟,不断推动临床、科研、教学与培训工作的进步。欢迎您浏览我们的网站: http://www.worldallergy.org/

世界变态反应组织(WAO)秘书处
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
电子信箱:info@worldallergy.org

您因如下原因收到此次通讯:您是世界变态反应协会会员,或者您曾向世界变态反应协会订阅过电子月刊,或者您以前曾与世界变态反应协会进行过有关联系。如果您不希望继续收到来自世界变态反应协会的信息,请以删除为主题回复此邮件。

Made possible through an unrestricted educational grant from Novartis.
由诺华教育基金提供资助

译者:北京协和医院 顾建青    Translated by Gu jianqing MD  PUMCH Dep. of ALLERGY