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May Medical Journal Review
五月世界医学杂志回顾
WAO Member Society Spotlight
聚焦WAO成员
WAO Now: What's New in the World of WAO
今日WAO:WAO领域新进展
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May World Medical Journal Review

五月世界医学杂志回顾

Prof. Richard F. Lockey, MD, WAO Web Editor-in-Chief, reviewed premier May medical journal articles for practicing allergists.
Richard F. Lockey教授,医学博士,WAO网站主编,他为在业的变态反应科医生回顾了五月医学杂志的一些重要文章。

1. LONG-TERM INHALED CORTICOSTEROIDS (ICS) IN PRESCHOOL CHILDREN AT HIGH RISK FOR ASTHMA
Two-hundred and eighty-five children, two or three years old, with a positive asthma predictive index were observed for one year and then given either fluticasone propionate (FP), 88µg 2x d, or placebo for two years. They were followed one additional year on no study medication or placebo. Treatment was associated with a significantly greater proportion of episode-free days, a lower rate of exacerbations, and less supplemental use of controller medications. At the end of the fourth year, the height increase was 0.7 cm less in the treatment group (P = 0.008). Even though the FP group did better during the two years of treatment, FP treatment did not alter the development of asthma or lung function during a third treatment-free year. Editor's comment: ICS are effective to treat pre-school children with asthma but do not alter long-term outcomes. Guilbert TW, et al. N Engl J Med 2006; 354: 1985. Gold DR, Fuhlbrigge AL, (editorial) 2058.
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1.哮喘高危的学龄前儿童长期吸入糖皮质激素(ICS)的影响
285 位年龄为2或3岁,且具有阳性哮喘先兆指数的儿童参加了这项研究,首先先观察一年,然后给予丙酸氟替卡松(FP),88µg 2x d,或安慰剂治疗两年。最后停用研究药物或安慰剂后再额外随访一年。结果治疗组的无症状天数明显增加,发作次数减少,控制药物的使用量也明显减少。在研究 的第四年末,治疗组的身高增长量比安慰剂组低0.7 cm(P=0.008)。虽然在FP治疗的两年中疗效较好,但第三年不采取治疗措施时,既往的FP治疗并不能逆转哮喘或肺功能的进展。编者按:ICS能有效治疗学龄前儿童的哮喘,但对长期预后没有改善。Guilbert TW, et al. N Engl J Med 2006; 354: 1985. Gold DR, Fuhlbrigge AL, (editorial) 2058.

2. INTERMITTENT INHALED CORTICOSTEROIDS IN INFANTS WITH EPISODIC WHEEZING
Two-hundred and ninety-four infants were randomly assigned to receive budesonide or placebo at their first episode of wheezing. Proportion of symptom-free days was similar in both groups as was persistent wheezing. The outcomes were not affected by the presence or absence of atopic dermatitis, and the mean duration of the acute episodes was identical in both groups and independent of respiratory viral status. Height and bone mineral density were not affected in either group. Inhaled budesonide has no short-term benefit during episodes of wheezing during the first three years of life nor does it affect the progression from episodic to persistent wheezing. Editor's comment: Finding a way to prevent these episodes may be the best solution for early onset episodic wheezing. Bisgaard H, et al. N Engl J Med 2006; 354: 1998. Gold DR, Fuhlbrigge AL, (editorial) 2058.
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2.发作性喘息婴儿间断吸入糖皮质激素的影响
294 例婴儿在他们第一次出现喘息发作时随机接受布地奈德或安慰剂治疗。和持续性哮喘一样,在这两组中无症状天数基本相同。而且,患儿是否存在特应性皮炎对疗效 没有影响,两组中急性发作的平均持续时间也是一样的,这也和患儿是否存在呼吸道病毒感染没有关系。两组患儿的身高和骨密度也没有差异。研究发现,3岁以内 儿童的喘息发作采用吸入布地奈德治疗没有明确的近期疗效,而且也不会影响发作性喘息发展成持续性喘息的这一进程。编者按:解决早发性发作性喘息的最好方法就是预防喘息发作。Bisgaard H, et al. N Engl J Med 2006; 354: 1998. Gold DR, Fuhlbrigge AL, (editorial) 2058.

3. EFFECT OF CODEINE ON OBJECTIVE MEASUREMENT OF COUGH IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Twenty-one patients with physician-diagnosed stable COPD with cough (77% male; mean age, 68 years; mean predicted FEV1, 53%; median smoking history, 43.5 pack-years) were studied in a DBPC crossover study. Cough frequency, cough seconds/hours, citric acid cough threshold, and subjective measurements were obtained. Codeine phosphate 60 mg or matched placebo was administered, in random order, at the start of each cough recording (0 and 12 hours). There were no significant differences in median time spent coughing, challenge thresholds, or subjective cough measures for codeine vs. placebo. Editor's comment: Codeine was no better than placebo to treat cough in patients with COPD. Smith J, et al. J Allergy Clin Immunol 2006; 117: 831.
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3. 客观测定可待因治疗慢性阻塞性肺病(COPD)引起咳嗽的效果
21 例经内科医生确诊为稳定期COPD,且伴有咳嗽症状的患者(男性占77%;平均年龄68岁;平均FEV1占预计值的百分数,53%;平均吸烟史,43.5 包年)参加了这项双盲安慰剂对照的交叉研究。研究主要观察指标包括,咳嗽频率,咳嗽持续秒数/小时,柠檬酸咳嗽阈值以及个人主观症状等。在每个咳嗽记录时 段(0时和12时)开始时,患者随机接受磷酸可待因60 mg或配对的安慰剂治疗。结果发现,可待因组和安慰剂组两者在咳嗽持续时间中位数,激发阈值以及主观判断咳嗽症状没有显著差异。编者按:在治疗COPD患者的咳嗽时,可待因的疗效和安慰剂类似。Smith J, et al. J Allergy Clin Immunol 2006; 117: 831.

4. SELF-ADMINISTRATION OF C1-INHIBITOR CONCENTRATE IN PATIENTS WITH HEREDITARY OR ACQUIRED ANGIOEDEMA (A) CAUSED BY C1-INHIBITOR DEFICIENCY
Thirty-one patients who had frequent A attacks participated in an hereditary or acquired C1-inhibitor deficiency study. Patients were trained to self-administer IV C1-inhibitor concentrate on-demand (31 patients) or prophylactically (12 patients). Mean follow-up was 3.5 years. Patients were able to self-administer the concentrate. The time between the onset of an attack and relief or complete resolution of symptoms in the on-demand group was shortened to 2.2 hours vs. 7.9 hours (baseline date) in the on-demand group. Prophylactic treatment decreased the A attack rate from 4.0 to 0.3 (baseline data) attacks per month. Editor's comment: Self-administered IV C1-inhibitor concentrate is effective both on-demand and prophylactically. Levi M, et al. J Allergy Clin Immunol 2006; 117: 904
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4. C1抑制物缺乏导致的遗传性或获得性血管性水肿(A)患者采用C1抑制物浓缩液自我给药的观察
31 例(应为43例)频繁发作血管性水肿的患者参加了这项遗传性或获得性C1抑制物缺陷的研究。首先教会患者静脉注射C1抑制物浓缩液的自我给药方法,然后分 成两组,其中采用必要时给药31例,预防给药12例。平均随访3.5年。患者能够掌握自行给药的方法。在必要时给药组中,血管性水肿开始发作至症状缓解或 完全消退的平均时间分别降至2.2小时和7.9小时。预防治疗组中,血管性水肿的发作频率从基线时的每月4.0次降至0.3次。编者按:患者自行静脉注射C1抑制物浓缩液时,不论必要时用药还是预防用药都是有效的。 Levi M, et al. J Allergy Clin Immunol 2006; 117: 904

5. RESPIRATORY SYNCYTIAL VIRUS (RSV), AIRWAY INFLAMMATION, AND FEV1 DECLINE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
RSV RNA was detected by PCR in 32.8% of 241 sputum samples collected quarterly over two years from 74 patients with stable COPD. Patients in whom RSV was more frequently detected (> than 50% of samples RSV PCR-positive, n = 18) had higher airway inflammation and faster FEV1 decline over the study period compared with those with less frequent detection of RSV. This relationship was independent of smoking status, exacerbation frequency, and lower airway bacterial load. Persistent RSV in COPD is associated with airway inflammation and accelerated decline in FEV1. Editor's comment: RSV infection may accelerate lung function decline in COPD. Wilkinson TMA, et al. Am J Respir Crit Care Med 2006; 173: 871.
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5. 慢性阻塞性肺病(COPD)患者中呼吸道合胞病毒(RSV),气道炎症以及FEV1下降之间关系的研究
作 者在两年内按季度平均收集了总共74例处于稳定期的COPD患者,在这些患者的241例痰标本中,通过PCR方法检测RSV RNA,阳性率为32.8%。结果发现,在整个研究期内,那些多次被检测出存在RSV感染的患者(>50%的痰标本中RSV PCR阳性,n=18)与其他患者相比,气道炎症反应更重,FEV1下降速度也更快。这种相关性与患者是否吸烟、症状发作频率以及气道细菌载量多少等均无 关系。COPD患者中持续存在的RSV与气道炎症和FEV1恶化加剧有关。编者按:RSV感染可能会加速COPD肺功能的恶化。Wilkinson TMA, et al. Am J Respir Crit Care Med 2006; 173: 871.

6. HIGH LEVELS OF MEDICAL UTILIZATION BY AMBULATORY PATIENTS WITH VOCAL CORD DYSFUNCTION (VCD) AS COMPARED TO AGE- AND GENDER-MATCHED ASTHMATICS
Twenty-five ambulatory patients with VCD were gender matched to 25 control patients with moderate persistent asthma. Total physician visits and subspecialty care visits were significantly greater among the VCD vs. the asthma cohort. Both groups had comparable utilization of prescriptions, frequency of hospitalizations, and urgent care visits. The authors conclude that VCD patients use significantly more medical services and similar pharmaceutical assets compared to patients with moderate persistent asthma. Editor's comment: VCD must be ruled out in every patient who presents with symptoms of asthma. Mikita J, Parker J, Chest 2006; 129: 905. Christopher K, (editorial) 842.
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6. 与匹配年龄和性别的哮喘患者相比,声带功能异常(VCD)的非卧床患者需要使用更多的医疗资源

25 例非卧床的VCD患者分别和25例同性别的中度持续性哮喘患者配对进行研究。和哮喘组相比,VCD患者总的就诊次数和附属专科就诊次数明显增多,而在使用 处方、住院次数以及急诊就诊次数等方面,两组间没有显著差异。作者结论认为,VCD患者比中度持续性哮喘患者需要使用更多医疗服务,但在使用药物方面两者 基本类似。编者按:对于每个有哮喘症状的患者,必须除外VCD。Mikita J, Parker J, Chest 2006; 129: 905. Christopher K, (editorial) 842.

7. CYSTEINYL LEUKOTRIENE RECEPTOR 1 PROMOTER POLYMORPHISM IS ASSOCIATED WITH ASPIRIN-INTOLERANT ASTHMA (AIA) IN MALES
Cysteinyl Leukotrienes (CysLTs) are important in the pathogenesis of AIA. Three CysLTR 1 promoter single nucleotide polymorphisms (SNPs) were associated with AIA risk in males, and males with AIA had significantly higher frequencies of the minor alleles (T,C,G) at the three SNPs than male control subjects. Moreover, the two common three-SNP haplotypes were also associated with AIA risk in males. The ht1 [C-A-A] haplotype was associated with decreased risk and ht2 [T-C-G] haplotype with increased risk. Males were younger than females in the AIA group. Male AIA patients carrying ht2 [T-C-G] may be at greater risk to develop AIA at an earlier age. There were no significant associations of CysLTR1 genotypes or three-SNP haplotypes with AIA risk in female patients. Genetic variants of CysLTR 1 are associated with AIA in a Korean population and may modulate CysLTR 1 expression. Editor's comment: Understanding the genetics of AIA will go along way in understanding its pathogenesis. Kim S-H, et al. Clin Exp Allergy 2006; 36: 433.
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7.在男性患者中半胱氨酰白三烯受体1启动子多态性和阿司匹林不耐受性哮喘(AIA)相关
半 胱氨酰白三烯(CysLTs)在AIA的发病机制中具有重要作用。3个CysLTR 1启动子单核苷酸多态性(SNPs)和男性AIA危险性相关,与男性对照个体相比,男性AIA患者在这3个SNPs上出现次要等位基因(T,C,G)的频 率明显升高。而且,这三个SNP单倍体中两种最常见的类型也和男性中的AIA危险性相关。ht1〔C-A-A〕单倍体与低危险性相关,ht2〔T-C- G〕单倍体与高危险性相关。在AIA患者中,男性的发病年龄要低于女性。男性AIA患者携带ht2〔T-C-G〕可能是引起患者在较年轻就发展成AIA。 而在女性患者中,未发现CysLTR1基因型或三个SNP单倍体和AIA危险性有明显的相关性。在韩国人群中,CysLTR1的遗传变异性和AIA相关, 且这种变异性可能最终影响到CysLTR1的表达。编者按:对于AIA遗传型的了解有助于人们认识它的发病机制。 Kim S-H, et al. Clin Exp Allergy 2006; 36: 433.

8. SAFETY OF SPECIFIC IMMUNOTHERAPY (SIT) USING A FOUR-HOUR ULTRA-RUSH INDUCTION SCHEME IN BEE AND WASP ALLERGY
Sixty-seven Hymenoptera allergic individuals received 80 outpatient courses of ultra-rush SIT. In 78 courses (97.5%), the maintenance dose of 111.1 µg was reached within four hours and was tolerated in 82.5% without any adverse reaction. Allergic reactions were observed in 17.5% (n = 14), all of which were local reactions and none of which was life-threatening. Ultra-rush IT to Hymenoptera (wasp and honeybee venoms) was safe, convenient,and completed within 4 hours in an outpatient setting. Editor's comment: Venom immunotherapy using a four-hour-ultra-rush IT schedule was safe. Roll A, et al. J Investig Allergol Clin Immunol 2006; 16: 79.
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8. 蜜蜂和黄蜂过敏患者使用四小时超快速诱导方案进行特异性免疫治疗(SIT)的安全性
67 例膜翅目昆虫过敏患者接受了共80个疗程的门诊超快速特异性免疫治疗(SIT)。其中有78个(97.5%)疗程在四小时内达到了111.1 µg的维持剂量,有82.5%耐受良好,未出现任何副作用。在这些治疗中,过敏反应的发生率为17.5%(n=14),但这些反应都是局部反应,没有出现 危及生命的严重反应。因此,膜翅目昆虫(黄蜂和蜜蜂毒液)过敏采用超快速IT既安全又方便,能在门诊的4小时内完成治疗。编者按:毒液免疫治疗采用四小时超快速IT方案是安全的Roll A, et al. J Investig Allergol Clin Immunol 2006; 16: 79.

9. INTRANASAL DELIVERY OF THE CYTOPLASMIC DOMAIN OF CTLA-4 USING A NOVEL PROTEIN TRANSDUCTION DOMAIN PREVENTS ALLERGIC INFLAMMATION
CTLA-4 is a negative regulator of T-cell activation. CTLA-4 was fused to a novel protein-transduction domain in human transcriptional factor Hph-1 to suppress allergic inflammation. The Hph-1-ctCTLA-4 fusion protein (FP) inhibited the production of IL-2 and downregulated CD69 and CD25. Intranasal administration of the FP, reduced infiltration of inflammatory cells, secretion of TH2 cytokines, serum IgE levels, and airway hyper-responsiveness in a mouse model of allergic airway inflammation. Thus, CTLA-4 might block the TH2 cell-polarized T-cell activation and potentially could be used intranasally to treat allergic asthma. Editor's comment: Another molecule which could possibly be used intranasally to downregulate allergic inflammation. Choi J, et al. Nature Medicine 2006.
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9. 细胞毒性T淋巴细胞相关抗原4(CTLA-4)胞浆区通过一个新的蛋白转导区进行鼻腔内给药预防过敏性炎症
CTLA -4是T细胞活化的一个负性调节蛋白。CTLA-4与人类转录因子Hph-1的一个新的蛋白转导区融合后抑制过敏性炎症。Hph-1-ctCTLA-4融 合蛋白(FP)能抑制IL-2的产生,下调CD69和CD25的表达。在过敏性气道炎症的小鼠模型中,鼻内使用FP能减少炎症细胞的浸润,减少TH2细胞 因子的分泌、降低血清IgE水平和气道的高反应性。因此,CTLA-4可能会阻断TH2型T细胞的活化,有可能采用鼻内用药治疗过敏性哮喘。编者按:这是另一种有可能采用鼻内给药下调过敏性炎症的分子。Choi J, et al. Nature Medicine 2006.

10. AN ANTIBODY-DEFICIENCY SYNDROME DUE TO MUTATIONS IN THE C19 GENE and INHERITED AND SOMATIC CD3ζ IN A PATIENT WITH T-CELL DEFICIENCY
Four patients with mutations in the CD19 gene had increased susceptibility to infection, hypogammaglobulinemia, and normal numbers of B-cells. The CD19 gene is responsible for generating CD19, a protein on the B-cell surface which forms a complex with other proteins that participate in activation of B-cells by antigens. In a SECOND article a child with greatly increased susceptibility to viral, bacterial, and fungal infections was found to have inherited a homozygous germ-line mutation of the CD3ζ gene. CD3ζ is a component of the CD3 T-cell-receptor complex and is essential for T-cell activation. These articles are accompanied by a superb editorial entitled, "Disabled Receptor Signaling and New Primary Immunodeficiency Disorders." Editor's comment: These articles and the editorial are must reading for physicians who do not understand the multiple defects that cause T-cell and B-cell immunodeficiencies. van Zelm MC, et al. N Engl J Med 2006; 354: 1901, Rieux-Laucat F, et al. 1913, Rudd CE, (editorial) 1874.
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10. C19基因突变导致的一种抗体缺陷综合症,以及CD3ζ因遗传和体细胞突变导致的T细胞功能缺陷
4 例CD19基因突变患者出现了易感染性增高,低丙种球蛋白血症,而B细胞数量正常。CD19基因是控制CD19分子合成的基因,CD19和B细胞表面的其 它蛋白一起形成一个复合物,参与B细胞受抗原刺激后的活化过程。第二篇文章介绍了一例儿童随着年龄增长,对病毒、细菌和真菌感染的易感性迅速增加,通过检 查发现他是一例CD3ζ基因纯合系的突变型。CD3ζ是CD3 T细胞受体复合物的一个组成部分,在T细胞的活化中起着重要作用。杂志编辑给这些篇文章作了一个很精彩的评论,标题是“受体信号缺陷及新的原发免疫缺陷 病”。编者按:对于因多重缺陷造成的T细胞和B细胞免疫缺陷病不是很了解的医生应该仔细阅读这些文章及评论。van Zelm MC, et al. N Engl J Med 2006; 354: 1901, Rieux-Laucat F, et al. 1913, Rudd CE, (editorial) 1874.

11. REVIEW OF THE USE OF INTRAVENOUS GAMMA GLOBULIN (IGIV) IN HUMAN IMMUNODEFICIENCY DISEASES
This is an evidence-based review of the use of IGIV for primary immunodeficiency,
secondary immunodeficiency, autoimmune diseases, asthma, and neurological disorders. Editor's comment: Article is full of wonderful tables and references and is excellent reading.
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11. 人类免疫缺陷病应用静脉输注免疫球蛋白(IGIV)的综述
这是一篇关于在原发免疫缺陷病、继发免疫缺陷病、自身免疫病、哮喘和神经系统疾病中应用IGIV治疗的循证医学综述。编者按:文章用很多具有说服力的表格及大量的参考文献来阐述这一问题,值得大家阅读。Orange JS, et al. J Allergy Clin Immunol 2006; 117: S525


WAO Member Society Spotlight – Austrian Society of Allergology and Immunology (ÖGAI)

聚焦WAO成员-奥地利变态反应和免疫学会(ÖGAI)

Dear colleagues and friends,
尊敬的各位同仁和朋友们:

Here is the news from the Austrian Society of Allergology and Immunology (ÖGAI). We really enjoyed hosting so many of you at the Congress of the EAACI in Vienna, June 10 – 14, 2006.
这是来自奥地利变态反应和免疫学会(ÖGAI)的最新报道,我们非常热情的接待你们大家来维也纳参加了于2006年6月10-14日召开的EAACI会议。

The booth of the Austrian Society of Allergology and Immunology in the "National Village" of this EAACI congress was a real success. You may remember that in our booth we offered not only information about Vienna but also delicious "Mozartkugeln," the famous sweets created in honor of Wolfgang Amadeus Mozart!
作为世界变态反应组织的一分子,奥地利变态反应和免疫学会在这次EAACI会议上的表现非常成功。你们可能还记得我们学会不仅为大家提供了维也纳的相关资料,而且还提供了为纪念沃尔夫冈·阿玛迪乌斯·莫扎特而制作的美味的“莫札特巧克力球”。

Last but not least, we would like to announce a newly funded Doctoral College CCHD (Cellular Communications in Health and Disease) at the Medical University Vienna, where we offer 24 doctoral positions for a newly established, high-quality PhD program. We cordially invite you to suggest that your best students apply for these truly attractive positions by the July 30, 2006 deadline.
最后但并非最不重要的一点是,我们刚刚在维也纳医学院新成立了一个关于CCHD(正常和疾病状态下细胞间通讯)的博士点基金,在此,我们为这个新建立的、 高质量的PhD项目提供了24 个博士名额。我们诚挚的邀请各位推荐你们最好的学生来申请这些具有真正吸引力的职位,申请截止日期是2006年7月30日。

The program offers cutting-edge education in the field of Neurobiology, Vascular Biology, Immunology and Inflammation Research and integrates basic, applied, and clinical sciences, as well as a huge spectrum of experimental techniques.
这个项目为大家提供了关于神经生物学、血管生物学、免疫学和炎症研究等领域最先进的教育,同时还整合了基础、应用和临床学科以及众多的实验室技术的内容。

Admitted PhD Students will receive funding for at least three years including support to visit international conferences and specialized workshops. Applicants must hold a final degree in the diploma studies of Medicine, Dentistry, or in any scientific/technical subject-related diploma (such as cell or molecular biology) by the commencing term of the program.
被录取的PhD学生将获得至少三年的基金资助,包括参加国际会议和专业研讨会。在参加这个项目前,申请人必须具有医学、口腔科学或其它任何相关科学/技术方面(例如细胞学或分子生物学)的文凭。

Further information on research topics and courses, as well as application forms, is available at: www.phd-cchd.at. Applications must be submitted by email to: phd_cchd@meduniwien.ac.at.
关于这个研究项目的课题和课程,以及申请表格等,详见www.phd-cchd.at。申请表必须通过电子邮件方式发送给phd_cchd@meduniwien.ac.at

Contributed by:
Prof. Erika Jensen-Jarolim, MD
WAO delegate of the ÖGAI
由奥地利变态反应和免疫学会的WAO代表
Erika Jensen-Jarolim教授
执笔


WAO Now: What's New in the World of WAO

今日WAO:WAO领域新进展

Introducing New GLORIA Modules
GLORIA最新介绍

The World Allergy Organization is excited to announce the launch of two new modules of our flagship educational program, GLORIA™ (Global Resources in Allergy™) at the meeting of the Singapore Society of Immunology, Allergy & Rheumatology, 15 July 2006, Tan Tock Seng Hospital.
世界变态反应组织在此隆重宣布,2006年7月15日新加坡免疫、变态反应和风湿病学会会议召开期间,我们的旗舰教育项目,GLORIA™ (Global Resources in Allergy™,全球变态反应研究)在Tan Tock Seng医院举办了两个新的讲座。

GLORIA Symposia:
GLORIA专题讨论会:

Module 8: Anaphylaxis
15 July 2006 from 8:20 a.m. – 9:20 a.m. in the TTSH Theatrette
第8讲:严重过敏反应
2006年7月15日8:20 a.m. – 9:20 a.m.,地点:TTS医院礼堂

Module 9: Diagnosis of IgE Sensitization
15 July 2006 from 10:40 a.m. – 11:40 a.m. in the TTSH Theatrette
第9讲:IgE致敏的诊断
2006年7月15日10:40 a.m. – 11:40 a.m.,地点:TTS医院礼堂

GLORIA Faculty: Cassim Motala, South Africa
GLORIA讲者: Cassim Motala,南非

New on the WAO Web Site
WAO网站新闻

In WAO Conversations, hear Allen P. Kaplan share his informal ideas on the treatment of Urticaria. To hear the interview, click here.
本期WAO访谈,我们将听到Allen P. Kaplan分享关于他关于荨麻疹治疗的一些非正式的观点。想聆听这次访谈,请点击此处

We are pleased to announce two new Interactive Case Reviews that are based on Clinical Case Reports published in the ACII-JWAO.
另外,我们还非常高兴的宣布,根据ACII-JWAO上发表临床病例报告,我们又设计了2个新的交互式病例回顾。

  • "The approach to recurrent upper respiratory infections," presented by Patrick J. DeMarco and Richard F. Lockey
  • Patrick J. DeMarco和Richard F. Lockey提供的“复发性上呼吸道感染的处理方法”
  • "Exercise -induced anaphylaxis," presented by Alexander T. Vu and Richard F. Lockey
  • Alexander T. Vu和Richard F. Lockey提供的“运动诱发的严重过敏反应”

To read the reviews, then make your diagnosis and learn if you agree with the experts, click here.
点击此处,阅读这些病例回顾,然后做出你的诊断,看你的答案是否和专家的一致。

WAO Short-Term Research Fellowships Awarded
公布WAO短期研究学员的名单

WAO has awarded three Short-Term Research Fellowships of $2,500 to enable young researchers to visit centers abroad and learn techniques to further their research programs. Congratulations to:
WAO将为每位学员提供$2,500,从而使年轻学者为了他们以后的研究计划,有条件访问国外的研究中心并学习技术。祝贺以下三位学者获得了短期研究学员的资格:

Eleonora Dehlink, Vienna, Austria who will visit Edda Fiebiger, Children's Hospital Boston, USA to further develop her project: Is Fc-epsilon-RI an antigen uptake/presentation receptor in the intestinal mucosa involved in the initiation of allergic immune responses in the gastro-intenstinal tract? An in-vivo approach.
奥地利维也纳的Eleonora Dehlink,为了进一步研究他的课题将到美国波士顿的儿童医院访问Edda Fiebiger,他的课题是:通过体内研究方法,判断在起动胃肠道变态反应免疫应答中,肠道粘膜的FcεRⅠ是否是作为一种抗原摄取/呈递受体?

Daniel P. Potaczek, Cracow, Poland who submitted an application to visit Hideoki Ogawa, Juntendo University School of Medicine, Tokyo where he will develop skills for his project: Genetic variability of alpha chain of high-affinity IgE receptor gene and its expression.
波兰克拉科夫的Daniel P. Potaczek,为了进一步提高他的课题研究方面的技能,将到东京的顺天堂大学医学部访问Hideoki Ogawa,他的课题是:高亲和力IgE受体α链基因的遗传变异性及其表达。

Dahlia Al-Ghoneimy, Cairo, Egypt who will study skin prick testing in the early diagnosis of atopy in infants and children, and the immunotherapeutic modalities. Her Fellowship will be hosted by G. Walter Canonica at DIMI, Genoa, Italy.
埃及开罗的Dahlia Al-Ghoneimy,他的研究是皮肤点刺试验在婴儿和儿童中特应性的早期诊断,以及免疫治疗的模式。他将在意大利热那亚DIMI的G. Walter Canonica指导下进行学习

Sign up for On-Line Journal Subscription
在线杂志订阅申请

WAO and Hogrefe & Huber Publishers are offering a limited number of free on-line subscriptions to Allergy & Clinical Immunology International - Journal of the World Allergy Organization for members in developing countries. If you are interested in receiving a complimentary, on-line subscription, please send an e-mail to info@worldallergy.org, noting "Free Journal Subscription" in the subject line, with the following details:

First name
Last name
Postal address
City, State/Province and postal code
Country
E-mail address
Name of Member Society

WAO和Hogrefe & Huber出版公司现为发展中国家的会员提供有限数量的《Allergy & Clinical Immunology International - Journal of the World Allergy Organization》免费在线订阅服务。如果您希望得到这份杂志的免费赠阅的电子版,请给我们发送e-mail至info@worldallergy.org,注意在信件的主题栏写“Free Journal Subscription”,并详细注明以下资料:

名字
姓氏
邮政地址
市,州/省和邮政编码
国家
E-mail地址
成员学会的名称


And In Other News

其他新闻

Allergy Book Review
变态反应学书评

Allergy and Asthma in Modern Society: A Scientific Approach
R. Crameri, Editor
2006 Karger
ISBN: 3-8055-8000-2
现代社会的变态反应和哮喘:进行科学的探讨
主编:R. Crameri
2006 Karger
ISBN: 3-8055-8000-2

List Price: $167.25 USD
Available from: Karger Publishing
定价: 167.25美元
出版商:Karger Publishing

Reviewer:
Dr David Sutherland, FRACP
Nineways Specialist Clinic, Broadmeadow NSW 2292
书评作者:
澳大利亚皇家内科医师学会会员,David Sutherland 博士
新南威尔士州Broadmeadow 2292,Nineways专科诊所

Description:
The prevalence of allergic diseases and bronchial asthma has increased throughout the industrialized world. This book is a collection of papers which seeks to explore the complex interactions between genetic and environmental factors that may have contributed to this increase. Contributions from a total of 40 authors have allowed a very broad coverage, ranging from epidemiology through to modern advances in molecular biology.
说明:
在所有的工业化国家,变态反应疾病和支气管哮喘的患病率均呈上升趋势。本书综合了很多专门研究遗传和环境因素之间复杂相互关系,并有可能促进这种上升趋势 的论文资料。本书共汇集了40位作者的著作,因而涵盖的内容也很广,包括从流行病学方面到分子生物学的现代进展。

Purpose:
This book was compiled as a tribute to Professor Kurt Blaser, Director of the Swiss Institute of Allergy and Immunology Research, Davos, to celebrate his 65th birthday.
目的:
编辑本书的目的是为了纪念(达沃斯)瑞士变态反应和免疫学研究学会主席,Kurt Blaser教授65华诞。

Audience:
No doubt this book was edited for those with a scientific interest in the etiology and management of bronchial asthma and allergic disease. However, this very scope and the large number of invited authors, means that there would be very few amongst the intended audience that would find all of the topics, ranging from epidemiology through to molecular immunology, equally helpful, or indeed, comprehensible.
读者:
毫无疑问,本书的读者是那些对支气管哮喘和变态反应疾病的病因学及其管理具有科学兴趣的人。但是由于本书的内容非常广泛,很多作者受邀参与了撰写,这也就 意味着对本书感兴趣的读者中,只有非常少部分人会发现所有这些课题包括从流行病学到分子免疫学,对他们而言都是有用的,或者确实都是很容易理解的。

Features:
This volume is divided into six sections: Introduction, The Environment, The Lung Eosinophils and Asthma, The Skin, Molecular Aspects of Allergy and Asthma, and Immunotherapy. Within this format, there are a total of 18 chapters. The Foreward to the volume is a tribute to Professor Blaser, and it concludes with a brief subject index. It is a slim well-presented volume of 224 pages.
特色:
本书共分为6部分:绪论,环境,肺部嗜酸性粒细胞和哮喘,皮肤,变态反应和哮喘的分子学基础,以及免疫治疗。根据这种结构,本书共分了18章。本书的序言部分是对Blaser教授的颂辞,接着是一个简要的主题索引。本书有224页,比较薄,但装订的很好。

Assessment:
Presumably as the result of the celebratory nature of this book, its contents are extremely varied, and perhaps idiosyncratic. The end result has been an in depth assessment of numerous aspects of asthma and allergic disease, rather than a comprehensive coverage. The scientific quality of the contributions is variable also. Those dealing with epidemiology and basic immunology are of a high quality. A chapter on allergic conjunctivitis includes 22 references. Only four of those references are from 2000 or later publications, and the author's name is included in all but one of the references. Some chapters, such as an examination of the affect of high altitude on bronchial asthma, and the role of sensitization to Malassezia sympodialis in atopic eczema, would be unlikely to warrant a whole chapter in another publication.
评估:
可能由于本书是一种具有纪念意义的书籍,因此它的内容极为广泛,有些还可能是很特殊的。总体而言,本书对哮喘和变态反应疾病的多个方面的进行了深入探讨, 而并非仅仅是内容广泛。同样本书中各份稿件的科学质量也各不相同。那些关于流行病学和基础免疫学的质量非常高。而关于过敏性结膜炎一章共有22篇参考文 献,但其中只有4篇参考文献是2000年或稍后出版的,且除了一篇参考文献以外,其它的都列有作者的名字。另外有些章节,例如高高度对支气管哮喘影响的检 测一章以及合轴马拉色菌(Malassezia sympodialis)致敏在特应性皮炎中的作用机制一章,这些内容在其它出版物中不太可能作为独立的一章。

Overall, this is a book to be used as a resource, rather than to be read from cover to cover. It would be a valuable addition to institutional libraries, and a useful purchase for clinical immunologists and allergists with wide-ranging scientific interests across the whole field of bronchial asthma and allergy. Others will find significant parts of this volume outside of their own areas of interest.
总体而言,这本书是用作一种参考资料,而不是用来全篇通读的。本书对于公共图书馆来说,是值得收藏的,对于支气管哮喘和变态反应整个领域具有广泛科学兴趣的临床免疫学家和变态反应学家而言,也值得购买。但其他人可能会发现本书中有相当多一部分内容在自己感兴趣的领域之外。

Find more allergy book reviews on the WAO Website here.
WAO网站上其它的变态反应学书评见此处

The World Allergy Organization's mission is to build a global alliance of allergy societies to advance excellence in clinical care, research, education and training. Visit us on the Web at http://www.worldallergy.org/

World Allergy Organization (WAO)
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世界变态反应组织的使命是建立一个全球性的变态反应学会联盟,不断推动临床、科研、教学与培训工作的进步。欢迎您浏览我们的网站: http://www.worldallergy.org/

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您因如下原因收到此次通讯:您是世界变态反应协会会员,或者您曾向世界变态反应协会订阅过电子月刊,或者您以前曾与世界变态反应协会进行过有关联系。如果您不希望继续收到来自世界变态反应协会的信息,请以“删除”为主题回复此邮件。

Made possible through an unrestricted educational grant from Novartis.
由诺华教育基金提供资助

译者:北京协和医院 顾建青    Translated by Gu jianqing MD  PUMCH Dep. of ALLERGY