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WAO News & Notes

June Medical Journal Review
六月世界医学杂志回顾
WAO Member Society Spotlight
聚焦WAO成员
WAO Now: What's New in the World of WAO- Long-Term Research Fellowship Applications

今日WAO:WAO领域新进展-长期研究学员资格申请
And In Other News . . .
其他新闻……

June World Medical Journal Review

六月世界医学杂志回顾

Mark C. Glaum, M.D., Ph.D., WAO Guest Editor, Assistant Professor of Medicine and Pediatrics, University of South Florida College of Medicine, reviewed premier June medical journal articles for practicing allergists.
WAO客座编辑,Mark C. Glaum,医学博士,哲学博士,南佛罗里达大学医学院内科和儿科学助理教授,他为在业的变态反应科医生回顾了六月医学杂志的一些重要文章。

1. ACID SUPPRESSION IMPROVES BREATHING FUNCTION IN PERSISTENT ASTHMATICS WITH GASTROESOPHAGEAL REFLUX (GERD) AND NOCTURNAL SYMPTOMS
Subjects with moderate to severe persistent asthma (n=770) were randomized to receive esomeprazole 40mg twice daily or placebo. Subjects were stratified into 3 groups: GERD with nocturnal symptoms; GERD without nocturnal symptoms; and nocturnal symptoms without GERD. In subjects with GERD and nocturnal symptoms, the esomeprazole-treated group showed improved morning (p = 0.03) and evening (p = 0.012) peak expiratory flows as compared to placebo. No improvement was observed in subjects without both GERD and nocturnal symptoms. Editor's comment: Treatment of gastroesophageal reflux is an important component of asthma management in certain patients. Kiljander TO, Harding SM, Field SK, et al. Am J Respir Crit Care Med 2006; 173: 1091-97
译文:
1.持续性哮喘患者伴有胃食管反流(GERD)并具有夜间症状采用抑酸治疗能改善呼吸功能
中 重度持续性哮喘患者(n=770)随机接受艾美拉唑40 mg一天两次或安慰剂治疗。受试者被再次分成3组:GERD且具有夜间症状;GERD且没有夜间症状;以及具有夜间症状但不伴有GERD。对于GERD且 具有夜间症状的患者,与安慰剂相比,艾美拉唑治疗能改善患者清晨(p = 0.03)和夜间(p = 0.012)的呼气流量峰值。而不同时具有GERD和夜间症状的受试者中则没有改善。编者按:对于某些患者而言,治疗胃食管反流是哮喘管理的一个重要组成部分。Kiljander TO, Harding SM, Field SK, et al. Am J Respir Crit Care Med 2006; 173: 1091-97


2. CONTACT HYPERSENSITIVITY IS MEDIATED BY NATURAL KILLER (NK) CELLS IN THE ABSENCE OF T AND B LYMPHOCYTES
Contact hypersensitivity is considered to be a T cell-mediated prototypical type IV Gel and Coombs reaction to haptens. Unexpectedly, in mice devoid of T and B lymphocytes, a model of contact dermatitis was found to be inducible with 2,4-dinitrofluorobenzene and oxazolone. If mice were depleted of all lymphocytes (including NK cells), contact hypersensitivity could not be induced. Specific contact hypersensitivity could be reconstituted in such mice after adoptive transfer of NK cells from NK-competent, sensitized donors. Editor's comment: NK cells are previously unrecognized mediators of hapten-specific immunity. Please also see excellent accompanying editorials. O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH. Nat Immunol 2006; 7(5): 507-16, Yokoyama WM; 437-9, Parham P. Nature 2006; 441(25): 415-16. No abstract is available.
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2.
在缺乏T和B淋巴细胞时,自然杀伤(NK)细胞可以介导接触性超敏反应
接 触性超敏反应通常认为是一种由T细胞介导的针对半抗原的典型的Ⅳ型变态反应。令人意想不到的是,在缺乏T和B淋巴细胞的小鼠中,使用2,4-二硝基氟苯和 恶唑酮可以诱导出接触性皮炎的动物模型。但如果小鼠的所有淋巴细胞(包括NK细胞)均被去除后,那就无法诱导出接触性超敏反应。再将具有足够NK细胞的已 经致敏供体的NK细胞过继转移给这些小鼠后,还可以重新建立特异性接触性超敏反应。编者按:以前人们忽视了NK细胞在半抗原特异性免疫的介导作用。同时注意阅读对该文章的精彩评论。Bisgaard H, et al. N Engl J Med 2006; 354: 1998. Gold DR, Fuhlbrigge AL, (editorial) 2058.


3. NOVEL BETA-2 RECEPTOR (B2) POLYMORPHISM IS ASSOCIATED WITH ASTHMA SEVERITY IN AFRICAN AMERICANS
Of 2,032 subjects recruited for a multicenter randomized, placebo-controlled, crossover safety study evaluating an inactivated influenza vaccine in patients with asthma, 517 patients consented to participate in a genetic sub-study to evaluate the association of particular B2 polymorphisms with asthma exacerbation rates and symptoms. Forty percent of African American asthmatics homozygous for a C523 allele experienced an asthma exacerbation in a two-week period following placebo vaccine injection as compared to 29% in heterozygotes (p = 0.018). Editor's comment: Further studies are warranted to evaluate associations between B2 variants and asthma phenotypes, particularly in minority populations. Lima, JJ, Holbrook, JT, Wang J, et al. Asthma 2006; 43:185-9
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3. 
新的β2(B2)受体多态性和非洲裔美国人哮喘的严重性有关
在 一项2,032例受试者参加的评估哮喘患者使用灭活流感疫苗的多中心、安慰剂对照的交叉安全性研究中,有517位患者同意参加其中遗传学方面的亚组研究, 以评价特殊的B2多态性和哮喘发作频率及症状之间的相关性。C523等位基因纯合子的非洲裔美国哮喘患者中,有40%在注射安慰剂疫苗后的2周内出现了一 次哮喘发作,而在杂合子中仅有29%(p = 0.018)。编者按:评价B2变异性和哮喘表型之间的相互关系还需要更多的研究来证实,尤其是关于少数裔人群方面的资料。Lima, JJ, Holbrook, JT, Wang J, et al. Asthma 2006; 43:185-9


4. SUBACUTE COUGH: IS IT A SEPARATE ENTITY?
One hundred eighty-four subjects diagnosed with subacute (lasting 3-8 weeks) cough were enrolled and treated prospectively using a clinical algorithm. Patients exhibiting clinical signs or symptoms of post-nasal drip or post-infectious cough were treated empirically with antihistamine/decongestant combination for 3 weeks. If no clinical improvement was noted, subjects were evaluated for airway hyperreactivity and, if sensitive, treated with inhaled corticosteroids. Of 184 subjects, 48% were found to have post-infectious cough, 33% had postnasal drip and only 16% had cough variant asthma that improved with inhaled corticosteroids. Editor's comment: Cough lasting 3-8 weeks is frequently post-infectious and self-limited. Kwon N, Oh M, Min T, et al. Chest 2006;129: 1142-7
译文:
4.
亚急性咳嗽:病因是否是多方面的?
184 诊断为亚急性(持续3-8周)咳嗽的患者参加了这项研究,并按照设计的临床方案进行经验性的治疗。如果患者出现后鼻滴流或感染后咳嗽的临床症状或体征,那 么使用抗组胺药/减充血剂经验性的联合治疗3周。如果临床上没有改善,那接着判断患者是否存在气道高反应性,如果存在高反应性,就用吸入皮质激素治疗。在 这184例患者中,48%是感染后咳嗽,33%是后鼻滴流,仅有16%是用吸入皮质激素治疗有效的咳嗽变异性哮喘。编者按:持续3-8周的咳嗽大多是感染后咳嗽,具有自限性。 Kwon N, Oh M, Min T, et al. Chest 2006;129: 1142-7


5. DEFICIENCY OF IgA AND IgG2 CORRELATES WITH ASTHMA SYMPTOMS AND LUNG FUNCTION
Severe and mild asthmatic adults (n= 31, ages 23-50) and 15 adult control patients were recruited to evaluate any association of low immunoglobulins with asthma symptoms, lung function and cellular markers of inflammation by endoscopic bronchial biopsy. Levels of IgG (p = 0.02) and IgA (p=0.006) were lower in severe asthmatics as compared to control subjects. Only low levels of IgA correlated with asthma symptoms and lung function (p<0.009), while levels of IgA and IgG positively correlated with numbers of tissue mast cells. Editor's comment: Alteration in levels of antibody production may be a marker of severe asthma phenotypes. Balzar S, Strand M, Nakano T, Wenzel SE. Int Arch Allergy Immunol 2006; 140:96-102
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5. IgA
IgG2缺乏和哮喘症状及肺功能相关
为 了评价免疫球蛋白水平降低和哮喘症状、肺功能以及经支气管镜活检测定的细胞炎症标志的相关性,31例(年龄23-50岁)中重度哮喘成人和15例对照成人 患者参加了研究。结果发现,和对照组患者相比,重度哮喘患者的IgG(p=0.02)和IgA(p=0.006)水平较低。但仅低水平的IgA和哮喘症状 及肺功能相关(p<0.009),而IgA和IgG水平和组织肥大细胞数量呈正相关。编者按:抗体产生水平的变化可能是重症哮喘的一个标志。Balzar S, Strand M, Nakano T, Wenzel SE. Int Arch Allergy Immunol 2006; 140:96-102


6. SPECIFIC SPUTUM INFLAMMATORY MARKERS CORRELATE WITH LUNG FUNCTION IN CYSTIC FIBROSIS BUT NOT CHRONIC BRONCHITIS
Expectorated sputum samples were obtained from 15 subjects with ATS-defined chronic bronchitis and 16 subjects with cystic fibrosis (CF) confirmed by sweat chloride test. Spirometry was performed at time of sputum collection and again at a later time point. Sputum samples were analyzed for presence of IL-8, myeloperoxidase (MPO) and DNA content. Cough transportability (CTR) of sputum (measure of adhesiveness) was also evaluated by in vitro methods. In subjects with CF, sputum concentrations of IL-8 and MPO were inversely correlated with FEV1 (p=0.003), while IL-8 and DNA concentrations were inversely correlated with CTR (p<0.05). No correlation was observed in subjects with chronic bronchitis. Editor's comment: Sputum concentrations of IL-8, MPO and DNA may serve as markers of airway obstruction in CF. Kim J, Okamoto K, Rubin BK. Chest 2006;129: 1148-54
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6.
某些特殊的痰液炎症标志和囊性纤维化的肺功能相关,但和慢性支气管炎的肺功能不相关
分 别收集15例根据ATS标准确诊的慢性支气管炎患者和16例通过汗液氯化物测试确诊的囊性纤维化患者的咳出的痰液标本。在收集痰液时以及收集后的某个时间 点分别对患者进行呼吸量测定。并检测痰液标本中的IL-8和髓过氧化酶(MPO)以及DNA的含量,同时通过体外测定法评价痰液的咳嗽流动性(CTR) (即测定痰的黏附性)。结果发现,CF患者的痰液中IL-8和MPO浓度和FEV1呈负相关(p<0.003),而IL-8和DNA含量则和CTR呈负相 关(p<0.05)。慢性支气管炎组患者中则未发现这种相关性。编者按:痰液中的IL-8MPODNA浓度可能是CF中气道阻塞的标志。Kim J, Okamoto K, Rubin BK. Chest 2006;129: 1148-54


7. POSITIVE ASSOCIATION BETWEEN AIR PARTICULATE LEVELS AND AIRWAY INFLAMMATION IN ASTHMATIC CHILDREN
Children with moderate to severe persistent asthma (n = 73) were followed prospectively over a two-year period. Daily concentrations of ambient fine particulates, daily use of bronchodilators, and levels of urinary leukotrienes were measured. Exposure to increased ambient particulates during the morning commute to school was associated with a 3.8% increase in bronchodilator use at school (p = 0.04). Stronger associations were noted in children with more severe asthma. Maximum morning particulate levels correlated with an average 6.2% increase in urinary leukotriene E 4 levels measured during school hours (p = 0.006) but not when levels were averaged over 24 hours. Editor's note: Exposure to ambient particulates may worsen airway inflammation and asthma symptoms in predisposed children. Also, see excellent accompanying editorial. Rabinovitch N, Strand M, Gelfand EW Am J Respir Crit Care Med 2006; 173:1098-1105, Delfino RJ, 173:1054-5 .
译文:
7.
哮喘患儿中,空气污染颗粒水平和气道炎症程度呈正相关
本 研究对患有中重度持续性哮喘的儿童(n=73)进行了为期2年的前瞻性随访。研究测定并记录了每天的空气污染颗粒浓度、每天的支气管扩张剂使用量以及尿液 中半胱氨酰白三烯的水平。研究发现,在早上去学校途中,随着暴露空气颗粒浓度的增加,在学校中支气管扩张剂的使用率也增加3.8%,两者之间具有相关性 (p=0.04)。而且研究还发现,随着患儿哮喘程度越重,这种相关性越强。早晨最高的颗粒浓度和在学校时测定的尿液白细胞三烯E4平均水平增高6.2% 相关(p=0.006),但与24小时内的平均白三烯E4水平不相关。编者按:对于某些易感儿童,暴露于空气污染颗粒可能会加剧气道炎症,恶化哮喘症状。同样建议仔细阅读对于此文章的评论。Rabinovitch N, Strand M, Gelfand EW Am J Respir Crit Care Med 2006; 173:1098-1105, Delfino RJ, 173:1054-5


8. PINE DUST EXPOSURE MAY PREDISPOSE TO ATOPY AND DECREASED LUNG FUNCTION
New Zealand sawmill workers with (n = 59) and without (n = 167) asthma symptoms assessed by questionnaire were evaluated for personal inhaled dust exposure, percutaneous allergen skin test reactivity and pre/post work shift spirometry. High exposure to “green” pine dust (from fresh cut timbers) was associated with sensitization to >3 outdoor pollens (OR 3.1, p<0.05), while high exposure to "green" and "dry" (from kiln-dried timers) dust was associated with reductions in FEV1 and PEF. Editor's comment: Exposure to certain particulates may modulate allergen sensitization and airway function. Douwes J, McLean D, Slater T, et al. Eur Respir J 2006; May 17 (doi: 10.1183/09031936.06.00120305) 
译文:
8.
暴露松树粉尘可能诱发特应性并降低肺功能
本 文对新西兰锯木厂的59例具有哮喘症状的工人和167例无哮喘症状的工人进行了研究,主要方法是通过问卷调查评价个人吸入粉尘的暴露史,通过皮肤试验测定 对过敏原的反应性以及在上班前/后分别进行呼吸量测定等。结果发现,对“潮湿”松树粉尘(来自刚刚砍伐的树干)具有高度暴露史的患者和患者对>3种室外花 粉存在敏感性相关(OR 3.1,p<0.05),而对“潮湿”和“干燥”(来自干燥的树干)松树粉尘同时具有高度暴露史就和FEV1和PEF的下降相关。编者按:暴露于某些颗粒可能会调节患者对过敏原的敏感性及其气道功能。Douwes J, McLean D, Slater T, et al. Eur Respir J 2006; May 17 (doi: 10.1183/09031936.06.00120305)


9. TASK FORCE REPORT ON SUBLINGUAL IMMUNOTHERAPY (SLIT)
This combined AAAAI/ACAAI task force report is a comprehensive review of the current evidence that supports the dosing, effectiveness and safety of sublingual immunotherapy. Other areas reviewed in this report include: the immunologic response to SLIT; changes in end organ inflammation; potential mechanisms and economics. Editor's comment: This report discusses the current literature regarding sublingual administration of immunotherapy and provides suggestions of where further studies are needed. Cox LS, Linnemann DL, Nolte H, et.al. J Allergy Clin Immunol 2006;117: 1021-35
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9.
关于舌下免疫疗法(SLIT)的工作小组报告
这份AAAAI/ACAAI联合工作小组报告是对当前支持舌下免疫治疗的使用剂量、有效性以及安全性证据方面的最广泛的回顾。这份报告还回顾了其它一些内容包括:SLIT的免疫学反应;改变终末器官的炎症反应;可能的作用机制和有关经济学方面的考虑。编者按:这份报告对当前文献中关于舌下给药免疫治疗方法进行了探讨,并指出了今后在那些方面还需要进一步的研究。Cox LS, Linnemann DL, Nolte H, et.al. J Allergy Clin Immunol 2006;117: 1021-35

10. Review of Testing and Treatment in Hereditary Angioedema
This review focuses on the current status of genetic testing for hereditary angioedema, however, it also provides a concise review of mechanisms, evaluation and treatment of the disease. There are several useful algorithms and charts that clearly summarize the classification of hereditary and acquired angioedema, as well as laboratory evaluation, treatment and surgical prophylaxis for patients with this problem. Editor's comment: This review summarizes evaluation and treatment of hereditary and acquired angioedema in a clear, accessible format. Weiler CR, Van Dellen RG. Mayo Clin Proc 2006; 81(7): 958-72
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10. 关于遗传性血管性水肿测定和治疗方面的综述
这篇综述主要介绍了遗传学检测在遗传性血管性水肿中的地位,同时也对该疾病的发病机制、病情评估以及治疗等做了简要的回顾。本文通过一些实用的处理步骤和图表,清晰的总结了遗传性和获得性水肿的分类,同时还对这种疾病患者的实验室评价、治疗以及术前预防等内容进行了总结。编者按:这篇综述通过简洁明了的方式对遗传性和获得性血管性水肿的评价和治疗进行了总结。Weiler CR, Van Dellen RG. Mayo Clin Proc 2006; 81(7): 958-72


WAO Member Society Spotlight – Japanese Society of Allergology

聚焦WAO成员-日本变态反应学会

The Japanese Society of Allergology (JSA) is pleased to announce that the forthcoming Fall Meeting, "Pursuing the Goal of Allergolgy – Elucidation of Pathologic Condition, Treatment and Prevention–" will be held at Tokyo International Forum in Tokyo, Japan on November 2-4, 2006. As a new initiative, the International Session, in which all presentations and discussions are conducted in English, is taking place. Its purpose is to promote the further internationalization of JSA so that JSA's biannual conferences will serve as the meeting ground for researchers from all over the world in the future. For more information on this conference, please contact allergy-56th@ped.dept.med.gunma-u.ac.jp. We welcome you to participate in our conference which will be attended by more than 3,000 Japanese researchers and will give them an opportunity to discuss their topics. The JSA members are looking forward to meeting you in Japan.
日本变态反应学会在此很高兴的宣布,秋季会议即将于2006年11月2-4日在日本东京的东京国际会议中心召开,本次会议的主题是“追寻变态反应学的目标 -阐明疾病的病理状况、治疗和预防-”。本次会议的创新之处在于会议还设置了国际分会场,在这个会场中所有讲者和讨论都采用英语。这样做的目的是为了促进 JSA的进一步国际化,我们希望今后能吸引全世界的研究者来参加JSA每年的两次会议。有关本次会议的详细资料,请联系allergy-56th@ped.dept.med.gunma-u.ac.jp。预计将有超过3,000位日本的研究者参加这次会议,并有机会一起讨论各自感兴趣的课题,我们热忱欢迎你们也来参加我们的会议。JSA会员期待着在日本与诸位相见。

Another significant announcement from JSA is that JSA's official English journal, "Allergology International" (AI), is available online. You are welcome to access the current issue (http://ai.jsaweb.jp/current.html) as well as the past issues (http://ai.jsaweb.jp/past.html). AI publishes peer-reviewed articles of scientific excellence in human and experimental allergology and related fields of research. The journal aims to further the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Letters to the Editors and Hypotheses. The journal is now accepting submissions of articles for possible publication. The acceptance for all papers is based on the quality and originality of the research and its significance to the journal's readership. Except where it otherwise states, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The original manuscript and three copies should be submitted to Editor-in-Chief, Allergology International, Japanese Society of Allergology, 7F Ishimizu Bld., 1-35-26 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. For further instructions regarding the submission of papers visit the website: http://ai.jsaweb.jp/
JSA的另外一个重要声明是:JSA官方的英文杂志《Allergology International》(AI)现在可以在线浏览。你们不仅可以访问现刊(http://ai.jsaweb.jp/current.html),而且还能够访问过刊(http://ai.jsaweb.jp/past.html)。 AI主要刊登关于人类和实验性变态反应学方面具有较高学术价值的同行评议文章,同时还包括一些相关领域的研究。我们的目标是今后将这份期刊办成国际学术成 果交流的平台,鼓励全世界的作者来本刊发表以下类别的文章,包括论著、病例报告、简要通讯、给编辑来信以及假说等。目前,本刊物接受大家的投稿。所有稿件 的接收标准都是根据研究的质量和原创性及其对杂志读者的重要性来判断的。除了一些特殊原因,稿件至少要经过两位匿名的审稿人和编辑同行的评阅。投稿时,请 将原稿和三份复印件寄至Editor-in-Chief (主编),Allergology International, Japanese Society of Allergology(日本变态反应学会), 7F Ishimizu Bld., 1-35-26 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan。关于投稿的具体要求请浏览我们的网站:http://ai.jsaweb.jp/

Provided by: Hirohisa Saito
The Japanese Society of Allergology
URL: http://www.jsaweb.jp/
E-mail: info@jsaweb.jp
作者:Hirohisa Saito
日本变态反应学会
网址:http://www.jsaweb.jp/
E-mail: info@jsaweb.jp


WAO Now: What's New in the World of WAO

今日WAOWAO领域新进展

WAO Long-Term Research Fellowship
WAO
长期研究学员资格

The World Allergy Organization (WAO) is offering a two-year Long-Term Research Fellowship, commencing late 2006. The Fellowship supports a junior allergist following an approved research program at a WAO proposed host center. A list of centers is included in the application. WAO will contribute a monthly stipend and yearly travel expenses.
世界变态反应组织(WAO)拟定在2006年底开始一项为期两年的研究学员培训项目。这个项目是用于资助低年资变态反应学工作者去WAO提议的研究中心跟 随一项被认可的研究计划进行学习。在申请表中列出了各个研究中心的名单。WAO将按月支付薪水和一年一次的旅途交通费用。

Priority will be given to junior clinicians within five years of award of the most recent professional degree, who are specializing in allergy and who are affiliated with an academic department or clinical institute. Applicants must be active members of a WAO member society.
这次培训将优先考虑那些在近5年内刚刚获得专业学位的、并以变态反应作为专业的低年资临床医生以及学术机构或附属临床医学院的临床医生。申请者必须是WAO成员学会的正式会员。
The Long-Term Fellowship will be applied to a project which meets one of the WAO Research Priorities:
这项长期研究学员项目将主要包括以下一些WAO的优先研究项目:

  • Genetic factors involved in the development of allergic disease and response to treatment
  • Allergen characterization and standardization
  • Clinical and basic studies in allergy and asthma
  • 遗传因素在变态反应疾病发展中的作用及其对治疗的影响
  • 过敏原鉴定和标准化
  • 关于变态反应和哮喘的临床和基础研究

Application forms may be downloaded here. :
点击此处下载申请表。

World Allergy Forum Held at the XXV Congress of the EAACI:
在EAACI第25届会议上举办了世界变态反应论坛:

"Life-Threatening Allergy – An Homage to Von Pirquet"
“致命性的变态反应-纪念Von Pirquet医生”

Our superb international faculty was chaired by Michael A. Kaliner and Anthony Frew, and provided a worldwide update on life-threatening allergy conditions. The first speaker, Aziz Sheikh (Edinburgh, Scotland), presented an analysis of the epidemiology of anaphylaxis, and the presentation by Richard F. Lockey (Tampa, FL. U.S.A.) focused on the mechanisms of anaphylaxis. The symposium was concluded by F. Estelle R. Simons (Winnipeg, Canada), who discussed management of anaphylaxis.
Michael A. Kaliner和Anthony Frew主持了这次盛大的国际论坛,会上给大家带来了当前世界上最新的关于致命性的变态反应的有关知识。第一位讲者,Aziz Sheikh (苏格兰,爱丁堡),介绍了严重过敏反应的流行病学资料,而Richard F. Lockey (美国,佛罗里达州,坦帕市)主要讨论了严重过敏反应的发病机制。最后由F. Estelle R. Simons (加拿大,温尼伯),进行了总结发言并介绍了关于严重过敏反应的管理。

Click here to view abstracts and slides and hear the presentations.
点击此处下载会议摘要和幻灯片及会议录音。

WAO Conversations
WAO
访谈

We are pleased to announce a new WAO Conversation, an interview with Malcolm R. Sears. To hear Dr. Sears discuss current issues associated with beta agonists, click here.
我们很高兴的宣布,最新一期的WAO访谈又和大家见面了,这次访谈人物是Malcolm R. Sears。如想了解Sears教授对于β激动剂当前某些问题的认识,请点击此处

Sign up for On-Line Journal Subscription
在线杂志订阅申请

WAO and Hogrefe & Huber Publishers are offering a limited number of free on-line subscriptions to Allergy & Clinical Immunology International - Journal of the World Allergy Organization for members in developing countries. If you are interested in receiving a complimentary, on-line subscription, please send an e-mail to info@worldallergy.org, noting "Free Journal Subscription" in the subject line, with the following details:
First name
Last name
Postal address
City, State/Province and postal code
Country
E-mail address
Name of Member Society

WAO和Hogrefe & Huber出版公司现为发展中国家的会员提供有限数量的《Allergy & Clinical Immunology International - Journal of the World Allergy Organization免费在线订阅服务。如果您希望得到这份杂志的免费赠阅的电子版,请给我们发送e-mail至info@worldallergy.org,注意在信件的主题栏写“Free Journal Subscription”,并详细注明以下资料:

名字
姓氏
邮政地址
市,州/省和邮政编码
国家
E-mail地址
成员学会的名称


And In Other News

其他新闻

Allergy Book Review
变态反应学书评

Lung Function Testing
European Respiratory Monograph 2005
Editors: R Gosselink and H Stam
肺功能测定
欧洲呼吸学会专著2005
主编:R Gosselink和H Stam

List price: $80.00 USD
Available from: Maney Publishing
定价: 80.00美元
出版商:Maney Publishing

Reviewer: Dr Janet Rimmer, MBBS, MD, FRACP. Woolcock Institute, University of Sydney, Australia
书评作者:澳大利亚悉尼大学Woolcock学院的Janet Rimmer医生,获得了内外全科医学学士,医学博士,澳大利亚皇家内科医师学会会员。

Description:
Lung function testing is an integral part of examination of the respiratory system. This monograph describes the main aspects of this evaluation process. Topics covered include spirometry, lung volumes, diffusion, control of breathing, muscle strength and sections on exercise testing. There are also sections on the less common areas such as forced oscillometry, testing in children and ICU patients. The basic methodology and interpretation is described and related to clinical disease states.
说明:
肺功能测定评价呼吸系统功能的一个必要项目。这篇专著讲解了肺功能测定过程中的一些主要内容,包括呼吸量测定法,肺容积,弥散,呼吸控制,呼吸肌力量以及 运动试验等章节。还有一些不常用的内容例如强迫振荡技术测定法,儿童以及ICU患者肺功能测定等也进行了介绍。本书还介绍了肺功能检测的方法学基础,并对 相应临床疾病状态的结果进行了解释。

Purpose:
To provide an up-to date approach to the performance and interpretation of respiratory function testing for clinicians.
目的:
给医生提供关于呼吸功能测定的操作方法和结果解释的最新观点。

Audience:
This book can be used by clinicians and researchers who are interested in understanding the theory and equipment used for the assessment and continued monitoring of respiratory diseases. The basic science is quite complex so that the book is probably not useful for medical students.
读者:
肺功能是评价和连续监测呼吸系统疾病的重要手段,本书适合那些希望了解这种仪器及其理论知识的医生和研究员。但由于这方面的基础学问非常复杂,因此本书可能不太适合于医学生。

Features:
This book is a very concise summary of the many different aspects of lung function. The reader needs to have an existing basic understanding of lung function to fully appreciate the text. It does cover the links between basic science, pathophysiology and clinical application which is a very useful approach. Each chapter provides an excellent summary of the main points.
特色:
本书对肺功能的多个方面都进行了简明扼要的介绍。如果读者想要完全理解本书的内容,还需要对肺功能有过一个基本的了解。本书通过将基础科学,病理生理学和临床应用三者有机的结合起来,因此使读者更容易理解。同时书中每一章都有精练的要点概述。

Assessment:
Lung function testing is the 31st European Respiratory Monograph, a series which commenced in 1995. While others in the series have addressed isolated components of lung function testing in detail, the current monograph provides a very concise (206 pages) summary of most aspects of lung function testing. Its advantages are that it covers both well established and new methodology and that every chapter has a section focussing on clinical application
评估:
欧洲呼吸学会系列专著从1995年开始出版至今,肺功能测定为第三十一册。虽然这套丛书中的其它专著也对肺功能的某些方面进行了详细的说明,但只有本书对 肺功能测定的很多内容进行了广泛扼要的介绍(206页)。本书的优势在于它不仅总结了以往的成果,而且也包括了新的方法学,而且每一章都用部分篇幅介绍其 临床应用。

Find more allergy book reviews on the WAO Website here.
WAO网站上其它的变态反应学书评见此处

The World Allergy Organization's mission is to build a global alliance of allergy societies to advance excellence in clinical care, research, education and training. Visit us on the Web at http://www.worldallergy.org/

World Allergy Organization (WAO)
Secretariat
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
Email: info@worldallergy.org

You have received this message because you are a member of a WAO Member Society, you have subscribed for the monthly e-letter or had previous contact with the World Allergy Organization. If you would prefer not to receive further messages from WAO, please reply to this message with REMOVE in the subject line.

世界变态反应组织的使命是建立一个全球性的变态反应学会联盟,不断推动临床、科研、教学与培训工作的进步。欢迎您浏览我们的网站: http://www.worldallergy.org/

世界变态反应组织(WAO)秘书处
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
电子信箱:info@worldallergy.org

您因如下原因收到此次通讯:您是世界变态反应协会会员,或者您曾向世界变态反应协会订阅过电子月刊,或者您以前曾与世界变态反应协会进行过有关联系。如果您不希望继续收到来自世界变态反应协会的信息,请以删除为主题回复此邮件。

Made possible through an unrestricted educational grant from Novartis.
由诺华教育基金提供资助

译者:北京协和医院 顾建青    Translated by Gu jianqing MD  PUMCH Dep. of ALLERGY