wao logo  


WAO News & Notes

August Medical Journal Review
八月医学杂志回顾
WAO Member Society Spotlight
聚焦WAO成员
WAO Now: What's New in the World of WAO
今日WAO:WAO领域新进展
And In Other News . . .
其他新闻

August World Medical Journal Review

八月医学杂志回顾

Prof. Richard F. Lockey, MD, WAO Web Editor-in-Chief, reviewed premier August medical journal articles for practicing allergists.
Richard F. Lockey教授,医学博士,WAO网站主编,他为在业的变态反应科医生回顾了八月医学杂志的一些重要文章。下面是由他精选的前3篇摘要,其它9篇摘要请点

1. DIRECT DETECTION OF BACTERIAL BIOFILMS ON THE MIDDLE-EAR MUCOSA (MEM) OF CHILDREN WITH CHRONIC OTITIS MEDIA (OM)
This study tested the hypothesis that chronic OM in humans is bacterial biofilm-related. MEM biopsy specimens were obtained from 26 children (mean age, 2.5 [range, 0.5-14] yrs) undergoing tympanostomy tube placement for OM with effusion (OME) and recurrent OM. Control biopsies were obtained from 8 subjects undergoing cochlear implantation. Samples were analyzed using microbiological culture, polymerase chain reaction (PCR) – based diagnostics, direct microscopic examination, fluorescence in situ hybridization and immunostaining. Mucosal biofilms were visualized by confocal laser scanning microscopic images using generic and pathogen-specific probes on 46 (92%) of 50 MEM specimens (vs none from controls) from children with OME and recurrent OM. Editor’s comment: The finding of biofilms on biopsy specimens from children with OME and recurrent OM supports the hypothesis of a cause and effect in the pathophysiology of chronic OM. Hall-Stoodley L, et al. JAMA 2006; 296: 202.
译文
1. 在慢性中耳炎(OM)儿童患者的中耳粘膜(MEM)中直接检测细菌生物被膜
这 项研究验证了人类慢性OM与细菌生物被膜相关的假说。研究者从26例(平均年龄2.5岁〔年龄范围,0.5-14岁〕)需要安置鼓膜造孔插管的渗出性中耳 炎(OME)和复发性中耳炎儿童患者中采集了MEM活检标本。8例进行耳蜗植入术的患者的活检标本作为对照。通过微生物培养,多聚酶链式反应(PCR)诊 断方法,直接显微镜检查,荧光原位杂交以及免疫染色等多种手段分析标本。结果发现,采用属和病原体特异性探针进行共聚焦激光扫描显微镜观察时,从OME和 复发性中耳炎儿童患者采集的50个MEM标本的影像中有46个(92%)能看到粘膜的生物被膜(而对照组中为0个)。编者按:从OME和复发性中耳炎儿童患者的活检标本的中找到了生物被膜,这就支持了生物被膜作为慢性OM的病因及其在病理生理学中作用的假说。Hall-Stoodley L, et al. JAMA 2006; 296: 202.

2. ULTRA-RUSH VENOM IMMUNOTHERAPY (VIT) INDUCES DIFFERENTIAL T CELL ACTIVATION AND REGULATORY PATTERNS ACCORDING TO THE SEVERITY OF ALLERGY
The objectives of this study were to assess the early effects of ultra-rush VIT on T lymphocyte activation and regulatory profile induction in 30 vespid-allergic patients according to the four severity grades of the Mueller classification. The authors found that a T helper type 2 (Th2)-to-Th1 switch occurs during ultra-rush VIT, in parallel with a natural and acquired regulatory T cell increase. These immunologic events occur earlier and at a higher level in less severe subjects, suggesting that VIT tolerance induction is easier to achieve in patients with less severe reactions. Editor’s comment: The immunologic changes induced during ultra-rush venom immunotherapy are impressive and easier to achieve in patients with milder vs more severe reactions. Mamessir E, et al. Clin and Exp Allergy 2006; 36: 704.
译文
2. 不同过敏严重程度的患者采用超快速毒液免疫治疗(VIT)会诱发不同的T细胞活化和调节模式
本 研究的目的是为了评价超快速VIT对T细胞活化和调节模式诱导作用的早期效应,受试者为30例黄蜂过敏的患者,并根据Mueller四级严重性分类法进行 了分级。作者发现在超快速VIT时,T辅助2型细胞(Th2)向Th1转化的同时伴随着天然和获得性调节T细胞的增加。而且患者的症状越轻,这些免疫学反 应事件发生的越早,改变程度也越高。这表明对于过敏反应症状越轻微的患者,VIT越容易达到诱导耐受。编者按:过敏反应程度轻微的患者和出现重症反应的患者相比,超快速毒液免疫治疗更容易诱导免疫学变化,同时这种改变的程度也越高。Mamessir E, et al. Clin and Exp Allergy 2006; 36: 704.

3. CONTROL OF AIRWAY INFLAMMATION MAINTAINED AT A LOWER STEROID DOSE WITH 100/50 μg OF FLUTICASONE PROPIONATE (FP)/SALMETEROL
Eighty-eight subjects, age > 18 yr, who demonstrated improved asthma control after an increase of FP from 100 μg twice daily to 250 μg twice daily were randomized to receive 100/50 μg of FP/salmeterol twice daily or continued FP 250 μg twice daily both through a Diskus inhaler for 24 weeks. Clinical outcomes, bronchial biopsy results, and bronchoalveolar fluid analysis results were similar. The authors conclude that a lower dose of FP with salmeterol versus a higher dose of FP is equally effective in controlling inflammation and asthma symptoms. Editor’s comment: Salmeterol augments the clinical benefits of FP. Jarjour NN et al. J Allergy Clin Immunol 2006; 118: 44.

译文
3. 用100/50 μg丙酸氟替卡松(FP)/沙美特罗的低剂量皮质激素维持控制气道炎症
88 例18岁以上哮喘患者经过从100 μg FP每日两次升级至250 μg每日两次后显示出哮喘控制改善,然后随机经干粉吸入剂吸入100/50 μg FP/沙美特罗每日两次或继续用FP 250 μg干粉剂每日两次连续治疗24周。临床结果,两者的支气管活检结果,支气管肺泡液分析结果均相似。作者结论指出,联合使用低剂量FP和沙美特罗与单用大 剂量FP在控制哮喘炎症和症状方面具有同等的效果。编者按:沙美特罗能增加FP的临床治疗效果。Jarjour NN et al. J Allergy Clin Immunol 2006; 118: 44.

4. SHORT COURSE OF SYSTEMIC CORTICOSTEROIDS (SC) IN SINONASAL POLYPOSIS (SP): A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL WITH EVALUATION OF OUTCOME MEASURES
Subjects with symptomatic endoscopically diagnosed SP received prednisolone (P) 50 mg daily for 14 days or placebo in a double-blind, randomized, placebo-controlled trial. The P-treated group showed significant improvement in nasal symptoms (P<.001); Rhinosinusitis Outcome Measure score (P<.001); and reduction in polyp size, as noted with nasendoscopy (P <.001) and MRI (P <.001). Fourteen days of prednisolone 50 mg daily was both safe and effective therapy for SP. Editor’s comment: Medical treatment for SP is effective. Hissaria P, et al. J Allergy Clin Immunol 2006; 118: 128.

译文
4. 短程应用全身皮质激素(SC)治疗鼻窦鼻腔息肉病(SP):双盲,随机,安慰剂对照临床试验评价其疗效观察指标
这 是一个双盲,随机,安慰剂对照的临床试验,受试者为内窥镜检查结果诊断的SP患者,他们随机接受强的松龙(P)每日50 mg或安慰剂治疗14天。结果发现,P治疗组在鼻腔症状(P<.001);鼻鼻窦炎疗效观察指标积分(P<.001);根据鼻内窥镜(P<.001)和 MRI(P<.001)观察到的息肉体积减小程度等各个指标方面均有显著改善。14天疗程的每日50 mg强的松龙治疗SP是安全有效的。编者按:采用内科方法治疗SP是有效的。Hissaria P, et al. J Allergy Clin Immunol 2006; 118: 128.

5. ANTI-APOPTOTIC FUNCTION OF A microRNA ENCODED BY THE HSV-1 LATENCY-ASSOCIATED TRANSCRIPT
The herpes simplex virus-1 (HSV-1) lies dormant in the peripheral nervous system until reactivated causing cold sores. Just one viral gene is expressed during the latency phase when no virus is produced. The virus produces a microRNA that protects infected neurons from apoptosis or cell death, so that the infection persists until reactivated. Editor’s comment: MiRNAs are not only major regulators of gene expression in mammalian cells but also in HSV-1, providing a hiding place in neurons for this virus. Gupta A, et al. Nature 2006; 442: 82. Editorial by Sugden B, p 33.

译文
5. 1-型单纯疱疹病毒潜伏相关转录物编码的microRNA的抗细胞凋亡功能
1-型单纯疱疹病毒通常在外周神经系统中处于休眠状态,而一旦再活化后就会引起感冒疮。潜伏期中不会产生病毒,也仅有一个病毒基因处于表达状态。病毒产生的microRNA能防止受感染的神经元出现细胞凋亡或细胞死亡,因此在再活化以前感染将持续存在。编者按:MiRNAs不仅是哺乳动物基因表达的重要调节因子,对于HSV-1也同样重要,能为这种病毒在神经元内提供一个隐匿之所。Gupta A, et al. Nature 2006; 442: 82. Editorial by Sugden B, p 33.

6. SAFETY AND EFFICACY OF SELF-ADMINISTERED SUBCUTANEOUS IMMUNOGLOBULIN (SCIg) IN PATIENTS WITH PRIMARY IMMUNODEFICIENCY DISEASES (PIDD)
This open-label study investigated the efficacy and safety of SCIg (16% IgG) in patients with PIDD. Sixty-five patients entered a three-month, wash-in/wash-out phase, designed to bring patients to a steady-state with SCIg. This was followed by 12 months of weekly SCIg infusions resulting in a mean weekly dose of 158 mg/kg. Mean trough serum IgG levels increased from 786 to 1,040 mg/dL during the study, a mean increase of 39%. The most frequent treatment-related adverse event was an infusion-site reaction, reported by 91% of patients and tolerated by most. Editor’s comment: SCIg is safe, effective and an alternative to IVIg. It should be more cost effective. Ochs HD, et al. J Clin Immunol 2006; 26: 265

译文
6. 原发性免疫缺陷病(PIDD)采用免疫球蛋白皮下自我给药(SCIg)疗法的安全性和有效性
这 项开放性研究观察了在PIDD患者中采用SCIg(16% IgG)治疗的安全性和有效性。65例患者参加了这项研究,该研究设计了为期3个月的洗入/洗出期,使患者经SCIg治疗后能达到一个稳定状态。接着每周 进行SCIg输注治疗连续12个月,最终平均每周的剂量为158 mg/kg。在研究期间,平均血清IgG谷浓度从786增加至1,040 mg/dL,平均增加了39%。最常见的与治疗相关的不良事件使输注部位的局部反应,患者报告的发生率为91%,但大部分都可以耐受。编者按:SCIg治疗是安全有效的,可以作为IVIG的替代治疗措施。而且这种疗法的成本效益比更优。Ochs HD, et al. J Clin Immunol 2006; 26: 265

7. THE UNDERRECOGNIZED BURDEN OF INFLUENZA (INF) IN YOUNG CHILDREN (CH)
This population-based surveillance of medical visits associated with laboratory-confirmed INF demonstrated that the average annual rate of hospitalization associated with INF was 0.9 per 1,000 CH (0-6 yr). The estimated burden was 50 clinic visits (CV) and 6 emergency department (ED) visits per 1000 CH during the 2002-2003 season and 95 CV and 27 ED visits per 1,000 CH during the 2003-2004 season. Few CH who had laboratory-confirmed INF were given a diagnosis of INF in the inpatient (28%) or outpatient (17%) settings. Outpatient INF was 10 to 250 times more common than hospitalized INF. Editor’s comment: INF commonly causes respiratory illness in children < 6 yrs. Perhaps all children < 6 yrs should be vaccinated for INF. Poehling KA, et al. N Engl J Med 2006; 355: 31.

译文
7. 未被充分认识的幼儿(CH)因流行性感冒(INF)造成的负担
这 是一项关于就诊症状结合实验室检查确诊的流行性感冒(INF)人群的调查研究,结果显示幼儿(0-6岁)平均每年与INF相关的住院率为千分之0.9 (0.9/1,000 个幼儿)。估计的疾病负担为,在2002-2003流感季节每1,000 CH有50例次门诊就诊(CV),6次急诊就诊(ED);2003-2004季节每1,000 CH有95次CV和27次ED。在经实验室检查确诊的INF幼儿中,只有少数被诊断成INF,其中住院患者中仅有28%,门诊患儿仅有17%。门诊患儿中 INF的发病率要比住院患儿高10-250倍。编者按:INF是导致6岁以下儿童呼吸道疾病的常见因素。也许所有6岁以下的儿童都应该注射流感疫苗。Poehling KA, et al. N Engl J Med 2006; 355: 31.

8. APHTHOUS ULCERATION
The author outlines an extensive differential diagnosis for recurring mouth ulcers. The etiology for aphthous ulcers remains unknown, but this condition can be quite bothersome and painful. Recommended treatment based on data available from randomized controlled trails includes topical corticosteroids in a paste, 5% amlexanox paste, or treatment with a mouth rinse such as chlorhexidine gluconate. Editor’s comment: Often times patients believe that aphthous ulcers and other mouth lesions are caused by allergy; therefore, it behooves allergists to understand the differential diagnosis and how to treat this common disorder. Scully C. N Engl J Med 2006; 355: 165.

译文
8. 阿弗他溃疡
作者总结了关于复发性口腔溃疡的各种鉴别诊断。虽然阿弗他溃疡的病因学尚不清楚,但这是一个非常令人讨厌的疾病,而且也很疼。根据现有的随机对照临床试验的数据推荐的治疗方法有,局部皮质激素贴剂,5%氨来占诺贴剂,或者用口腔清洗剂治疗,如葡萄糖酸洗必太。编者按:很多患者常认为阿弗他溃疡以及其它口腔病损是由过敏引起的;因此变态反应科医生应该掌握本病的鉴别诊断及其治疗。Scully C. N Engl J Med 2006; 355: 165.

9. TREATMENT OF CHRONIC RHINOSINUSITIS (CRS) AND ITS EFFECTS ON ASTHMA
This paper reports on the results of 43 patients with CRS with and without nasal polyps and concomitant asthma. Both medical and surgical treatment were associated with subjective and objective improvements in asthma. However, it was better maintained following medical therapy, where improvement could also be demonstrated in the subgroup of patients with nasal polyps. Medical vs. surgical therapy was also superior with respect to a decrease in exhaled nitric oxide and increase in FEV1 in polyp patients. Editor’s comment: This study demonstrates that medical or surgical treatment of CRS improves asthma. Medical treatment seems to be better. Ragab S, et al. Eur Respir J 2006; 28: 68.

译文
9.慢性鼻鼻窦炎(CRS)的治疗及其对哮喘的影响
这 是一篇关于43例CRS同时伴有哮喘患者的总结报告,患者可伴随或不伴有鼻息肉。内科和外科治疗都能导致哮喘主观症状和客观指标的改善。其中以内科治疗改 善效果较好,而且同时伴有鼻息肉这一亚组患者的哮喘症状也能得到改善。就鼻息肉这组患者的呼出气体一氧化氮下降和FEV1增加而言,内科治疗的效果也同样 优于外科治疗。编者按:这项研究显示CRS的内科或外科均能改善哮喘。其中内科治疗看来效果要更好一些。Ragab S, et al. Eur Respir J 2006; 28: 68.

10. TOWARDS SUBTLETY: UNDERSTANDING THE ROLE OF TOLL-LIKE RECEPTOR (TLR) SIGNALING IN SUSCEPTIBILITY TO HUMAN INFECTIONS.
There has been a dramatic improvement in understanding the role of innate immunity, in particular, TLR signaling in human host defense. In six pages, these authors brilliantly outline defects in human TLR signaling which enhance susceptibility to infection. The review highlights the mechanisms of infectious susceptibility that result from complex interactions between the genetically variable host and microbe and explores how this knowledge ultimately will translate into better care for patients. Editor’s comment: Abnormalities of the innate immune system, in this case, TLR signaling, are important in clinical medicine. Turvey SE, Hawn TR. Clin Immunol 2006; 120: 1.

译文
10.走向敏锐:理解TOLL样受体(TLR)信号传导在易感染人群中的作用
人 们在认识先天免疫,特别是TLR信号传导在人类宿主防御中作用曾经有过戏剧性的提高。这些作者们用了6页的篇幅高度概括了人类TLR信号传导缺陷后会增加 对感染的易感性。这篇综述着重介绍了因宿主遗传变异和微生物之间复杂相互作用导致易感染的机制,同时还探讨了为什么这些知识最终将转化成为患者提供更好的 医疗服务。编者按:先天免疫系统的异常,在本文中,即TLR信号传导异常,是内科临床中的一个重要问题。Turvey SE, Hawn TR. Clin Immunol 2006; 120: 1.

11. REVIEWS ON ATOPIC DERMATITIS (AD)
The July JACI has a variety of papers on AD. Subjects discussed include: Epidermal barrier dysfunction in AD and gene-environment interaction, genetics of AD, clinical pearls about this subject, a consensus report on AD from the European and American Academies, the vasculature in AD, sleep disturbance associated with AD and its management, innate immune defects in AD, a Rostrum article challenging three prevailing concepts, an original article about "“Loss of function variations within the filaggrin gene predispose for AD", and patient perspectives about AD. Editor’s comment: Progress is being made in understanding and treating this complex vexing medical problem. J Allergy Clin Immunol, July 2006; 118(1)

译文
11.关于特应性皮炎(AD)的综述
7 月份的JACI杂志刊登了各种关于AD的文章。讨论的题目包括:AD的表皮屏障功能障碍和遗传-环境相互作用,AD的遗传学,关于这个课题的临床精要知 识,来自欧洲和美国学术团体关于AD的共识报告,AD的脉管系统,AD相关的睡眠障碍及其管理,AD的先天免疫缺陷,一篇讨论三个AD常见问题的讲演性的 文章,一篇关于“中间丝相关蛋白基因功能缺失变异容易导致AD”的论著,患者对AD的看法。编者按:人们认识和治疗这种复杂、令人烦恼疾病的水平正在逐步提高,肥大细胞是一类独特的复杂的细胞,并且至今依然是变态反应炎症的哨兵细胞。 J Allergy Clin Immunol, July 2006; 118(1)

12. UPDATE IN GENERAL INTERNAL MEDICINE (IM)
This paper summarizes the major advancements in IM published in 2005 of interest to general practitioners. For example, the herpes zoster virus vaccine is recommended for all immunocompetent patients > to 60 yrs of age. In addition, vitamin D, 800 IU/d, plus calcium supplements are recommended for women at high risk for fracture. Another recommendation to consider is tiotripium bromide therapy for patients with COPD. Physicians also should stop prescribing high dose vitamin E supplements (no benefit) and bisphosphonate therapy (not cost-effective) to prevent fractures in women with osteopenia (T-score between -1.5 and -2.4). Editor’s comment: A wonderful easily understood review of major innovations in medicine for all physicians. Knight CL, Fihn SD. Ann Intern Med 2006; 145: 52.
译文
12.普通内科学的最新资料(IM)
这 篇文章总结了2005年发表的、全科医生感兴趣的关于IM的重要进展。例如,建议所有年龄在60岁以上的具有免疫能力的患者都应该注射带状疱疹病毒疫苗。 另外,建议具有高危骨折危险的妇女每天服用800 IU维生素D加钙补充剂。其它的建议是认为COPD患者应该采用替托溴铵治疗。医生不应该处方大剂量维生素E补充剂(无效)和二碳磷酸盐化合物(成本效益 比较差)来预防骨量减少(T积分为-1.5~-2.4)的妇女发生骨折。编者按:对于所有医生而言,这篇综述介绍的关于内科方面的重要革新是很精彩的,也易于理解。Knight CL, Fihn SD. Ann Intern Med 2006; 145: 52.


WAO Member Society Spotlight –The CIS Society of Allergology and Immunology

聚焦WAO成员-独联体国家变态反应和免疫学会

The CIS (Commonwealth of Independent States) Society of Allergology and Immunology is a non-government organization that co-ordinates the activities of medical scientists and public health specialists in Russia and other CIS countries in the field of allergology, immunology and asthma basic research, prophylaxis and management. The Society unites over 4,500 members from 12 CIS countries as well as 15 national and 7 regional societies of allergologists and immunologists. The CIS Society of Allergology and Immunology publishes four journals: "Allergology and Immunology," "Asthma," "International Journal on Immunorehabilitation," and an Abstract Journal "Immunophysiology, Immunorehabilitology, Clinical Immunology and Allergology" (jointly published with the Russian Academy of Sciences). Our Society is the successor of the Soviet Union Immunological Society that was founded in June 1983 with the first Congress held in 1989.
独 联体国家变态反应和免疫学会是一个非政府组织,她是俄罗斯和其他独联体国家的变态反应学、免疫学和哮喘基础研究、预防和管理等领域的医学科学家和公共卫生 专家开展活动的舞台。学会拥有超过4,500的会员,成员不但来自12个独联体国家还包括其他15个国家和7个地区学会的变态反应学家和免疫学家。独联体 国家变态反应和免疫学会出版有四份期刊:《变态反应学和免疫学》,《哮喘》,《国际免疫康复》和摘要期刊《免疫生理学,免疫康复学,临床免疫学和变态反应 学》(和俄罗斯科学院联合出版)。我们学会是继承成立于1983年6月,并在1989年召开第一届会议的苏联免疫学会。

The CIS Society of Allergology and Immunology is a WAO member alongside international and regional organizations such as EAACI, AAAAI, and ACAAI.
独联体国家变态反应和免疫学会是WAO会员,也是和EAACI,AAAAI,及ACAAI一样的国际和地区组织。

Our Society has a wealth of experience in organizing important international congresses and conferences. In 2001, we hosted the I European Asthma Congress in Moscow; in 2003, the XVII World Asthma Congress was held in Saint-Petersburg, and our events in the Bolshoi Theater in 2001 and in Petershoff in 2003 are engraved in the memory of these congress participants.
我 们学会有着丰富的组织重要国际会议和各种大会的经验。2001年,我们在莫斯科主办了第一届欧洲哮喘会议;2003年,在圣彼得堡主办了第十七届世界哮喘 会议,在2001年的俄罗斯大剧院及2003的Petershoff,我们出色的工作为这两次会议的与会人员留下了深刻的印象。

On September 11-13, 2006, the VI CIS Congress of Immunology and Allergology took place in Moscow. The Opening Ceremony of the Congress included the official presentation of the Russian Edition of Allergy & Clinical Immunology International – Journal of the World Allergy Organization. It was a very important event for allergists and immunologists in post-Soviet countries and became a reality due to our cooperation with Professor Allen Kaplan, a former President of WAO, and financial support of the project by the Immunology Research Institute of New England (IRINE). We hope that the publication of such a prominent journal in Russian will contribute to further development of allergology and immunology in the CIS countries and improve educational levels of not only allergologists and immunologists but also specialists involved in related fields. It will also promote higher levels of medical care standards in the CIS countries and the implementation of recent research into clinical practice, which is one of the key tasks of our Society. Another important aim of the CIS Society of Allergology and Immunology is to establish a bridge connecting scientists and health care practitioners.
2006 年9月11-13日,在莫斯科召开了第六届独联体国家免疫学和变态反应学会议。在会议的开幕式上,俄语版的《Allergy & Clinical Immunology International – Journal of the World Allergy Organization》正式宣布出版。这对于后苏联时代的国家的变态反应学家和免疫学家来说,是一个非常重要的事件,这件事情的成功源于我们和WAO 前任主席Allen Kaplan的密切合作,同时也要感谢新英格兰免疫研究所(IRINE)提供了资金资助计划。我们希望随着这种优秀杂志在俄罗斯的出版,会给独联体国家的 变态反应学和免疫学带来长足的发展,不仅能提高变态反应学家和免疫学家的教育水平,而且对其他相关领域的专家也有益处。同时,这也将促使独联体国家的医疗 保健标准上一个新的台阶,以及提高科研成果向临床实践的转化,后者也是我们学会的关键任务之一。独联体国家变态反应和免疫学会的另一个重要任务是在科学家 和卫生保健工作者之间起到桥梁作用。

In April 2007, the VII CIS Congress of Allergology and Immunology will take place in Moscow. From April 21 through April 24, 2007, we will have a great chance to host the V European Asthma Congress and the I World Congress on COPD in Moscow. We would be happy to meet allergologists, immunologists, pulmonologists, pediatricians and other health care practitioners from all over the world. Our guests will have an opportunity to visit the most beautiful and famous sights of Moscow such as the Kremlin, the Red Square, the Manezh Exhibition Hall, the Bolshoi Theater, the Pushkin Fine Arts Museum, Christ the Savior Cathedral, Vassily the Blessed Cathedral, the State Tretyakov Gallery complex, the Panorama museum of the Battle of Borodino, the Novodevichy Convent, and the Memorial museum on Poklonnaya Gora.
2007 年4月,第七届独联体国家免疫学和变态反应学会议将在莫斯科召开。在2007年4月21-24日的莫斯科,我们将很有可能主办第五届欧洲哮喘会议,和第一 届世界COPD会议。我们期待着与来自世界各地的变态反应学家、免疫学界、肺脏学家、儿科学家以及其他卫生保健工作者相聚。我们的客人将有机会参观莫斯科 最美丽著名的景点,例如克里姆林宫,红场,莫斯科中央展览馆,俄罗斯大剧院,普希金美术馆,基督救世大教堂,圣瓦西里大教堂,国立崔雅科夫美术馆,博罗地 诺战争纪念馆,新圣女修道院,以及列宁山Poklonnaya Gora战争纪念馆。

Provided by: Professor Revaz Sepiashvili, MD, PhD
President, CIS Society of Allergology and Immunology
E-mail: info@wipocis.org
独联体国家免疫学和变态反应学会主席
医学博士,哲学博士 Revaz Sepiashvili 教授,执笔
电子邮件: info@wipocis.org


WAO Now: What's New in the World of WAO

今日WAO:WAO领域新进展

gloria logoUS GLORIA Program
美国GLORIA计划

WAO, in collaboration with the American College of Allergy, Asthma, and Immunology (ACAAI), is excited to launch our first year of the US GLORIA program, which has been developed to promote the mission of both WAO and ACAAI to optimize allergy care in the United States.
我们很高兴得宣布,经过WAO和美国变态反应,哮喘和免疫学会(ACAAI)的大力合作,第一年的美国GLORIA计划将正式开始实施,目的是为了提高美国变态反应医疗水平,这也是WAO和ACAAI所面临的任务。

Launching this fall, GLORIA modules will be presented at US Regional, State and Local allergy societies for CME credit. Click here if your society is interested in applying for this new program in 2007; the deadline to apply is November 30.
自今年秋季开始,GLORIA项目将在美国的不同地区,各州以及当地的变态反应分会组织实施,并将授予医学继续教育学分。如果你们地区分会希望申请这个新项目的2007年度计划,请点击此处;申请截止日期为11月30日。

2006 Placements
2006度项目安排

Northwest Allergy Forum
September 29 – October 1, 2006
Tacoma, Washington
US GLORIA Faculty:
Dr. Richard Lockey
Presentations:
Module 7: Angioedema
Module 8: Anaphylaxis
西北变态反应论坛
2006年9月29日至10月1日
华盛顿州,塔科马
美国GLORIA教员:
Richard Lockey医师
课程内容:
项目7: 血管性水肿
项目8: 严重过敏反应

Los Angeles Society of Allergy, Asthma, and Clinical Immunology, Inc.
October 21, 2006
Brentwood, California
US GLORIA Faculty:
Dr. Michael Kaliner
Presentation:
Module 8: Anaphylaxis
洛杉矶变态反应哮喘和临床免疫学会
2006年10月21日
加利福尼亚州,布伦特伍德
美国GLORIA教员:
Michael Kaliner医师
课程内容:
项目8: 严重过敏反应

Broward Palm Beach Allergy Society
November, 2006
Boca Raton, Florida
US GLORIA Faculty:
Dr. Phil Lieberman
Presentation:
Module 8: Anaphylaxis
布劳沃德和棕榈滩县变态反应学会
2006年11月
佛罗里达州,博喀拉藤
美国GLORIA教员:
Phil Lieberman医师
课程内容:
项目8: 严重过敏反应

Mid-South Allergy Forum
December 5, 2006
Memphis, Tennessee
US GLORIA Faculty:
Dr. Bob Lanier
Presentation:
Module 4: Immunotherapy
中南变态反应论坛
2006年12月5日
田纳西州,孟菲斯
美国GLORIA教员:
Bob Lanier医师
课程内容:
项目4:免疫治疗

Greater Washington Asthma, Allergy and Immunology Society
December 6, 2006
Tyson's Corner Area, Virginia
US GLORIA Faculty:
Dr. Michael Kaliner
Presentation:
Module 8: Anaphylaxis
大华盛顿哮喘变态反应和免疫学会
2006年12月6日
弗吉尼亚州,泰森斯科纳商城地区
美国GLORIA教员:
Michael Kaliner医师
课程内容:
项目8:严重过敏反应

Indiana Allergy and Immunology Society
December 9, 2006
Indianapolis, Indiana
US GLORIA Faculty:
Dr. Ira Finegold
Presentations:
Module 4: Immunotherapy
Module 5: The Symptoms and Treatment of Asthma Immunotherapy
印地安纳州变态反应和免疫学会
2006年12月9日
印度安纳州,印第安纳波利斯
美国GLORIA教员:
Ira Finegold医师
课程内容:
项目4:免疫治疗
项目5:免疫治疗

Emerging Societies Meeting Held in Latin America
新学会会议在拉丁美洲召开

An Emerging Societies Meeting, jointly funded by the American College of Allergy, Asthma and Immunology (ACAAI) and WAO, took place on Friday, August 18, 2006, at the Latin American Congress of Allergy, Asthma and Immunology in Buenos Aires, Argentina. The goals of this meeting were to provide outreach in regions where established allergy societies do not exist, improve standards for existing societies and improve standards for research.
2006年8月18日,星期五,在阿根廷布宜诺斯艾利斯召开的拉丁美洲变态反应哮喘和免疫学大会上,由美国美国变态反应,哮喘和免疫学 会(ACAAI)和WAO联合赞助的新学会会议同时召开。会议的目的是为那些尚未成立变态反应学会的地区提供支持,提高已成立学会的水平和研究标准。

National Allergy Society representatives from Latin America were invited to attend, and Allergy Societies that do not currently belong to WAO were asked to give brief presentations on the practice and structure of allergy services in their countries. They were able to identify the most pressing needs related to allergy education in their countries and also provide WAO with a 'wish list' of services that they would like to receive.
来 自拉丁美洲各国家变态反应学会的代表应邀参加了会议,对于那些目前尚未加入WAO的变态反应学会,大会邀请他们简要介绍了各自国家的变态反应实践和变态反 应服务体系的情况。他们可以向大会说明目前在他们国家有关变态反应教育方面的最迫切需求,同时也给WAO提供了他们希望接受援助服务的“意愿表”。

Presenters:

Nicaragua Guiselle Urbina Palacios
Honduras Claudia Almandarez Flores
El Salvador Maria Emilia Castro Mendoza
Haiti/French Departments of America Sylvie Lafosse-Marin
Guatemala Ann-Michelle Rigalt

讲演者:

尼加拉瓜 Guiselle Urbina Palacios
洪多拉斯 Claudia Almandarez Flores
萨尔瓦多 Maria Emilia Castro Mendoza
海地/French Departments of America Sylvie Lafosse-Marin
危地马拉 Ann-Michelle Rigalt

New on the WAO Web Site
WAO网站的新闻

We are pleased to announce a new Interactive Case Review based on a Clinical Case Report published in the ACII-JWAO. "A patient with yellow nails" is presented by Denise M. Kearney and Richard F Lockey. To read the review, then make your diagnosis and learn if you agree with the experts, click here.
我们很高兴得宣布,新一期的根据ACII-JWAO上发表的病例报告设计的交互式病例分析又和大家见面了。这期是由Denise M. Kearney和Richard F Lockey编写的《一位黄色指甲的患者》。阅读这个病例资料,然后作出你的诊断,看看是否和专家的意见一致,详情请点击此处

Sign up for On-Line Journal Subscription –
在线杂志订阅申请-

WAO and Hogrefe & Huber Publishers are offering a limited number of free on-line subscriptions to Allergy & Clinical Immunology International - Journal of the World Allergy Organization for members in developing countries. If you are interested in receiving a complimentary, on-line subscription, please send an e-mail to info@worldallergy.org, noting "Free Journal Subscription" in the subject line, with the following details:

First name
Last name
Postal address
City, State/Province and postal code
Country
E-mail address
Name of Member Society

WAO和Hogrefe & Huber出版公司现为发展中国家的会员提供有限数量的《Allergy & Clinical Immunology International - Journal of the World Allergy Organization》免费在线订阅服务。如果您希望得到这份杂志的免费赠阅的电子版,请给我们发送e-mail至info@worldallergy.org,注意在信件的主题栏写“Free Journal Subscription”,并详细注明以下资料:

名字
姓氏
邮政地址
市,州/省和邮政编码
国家
E-mail地址
成员学会的名称


And In Other News

其他新闻

Allergy Book Review
变态反应书评

Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease
By: Novartis Foundation
肥大细胞和嗜碱性粒细胞:发育,活化,及其在变态反应/自身免疫性疾病中的作用
诺华基金会 出版

List price: $145.00 USD
Available from: Wiley
定价:145.00美元
定购网址: Wiley

Reviewer:
Mark C. Glaum, MD, PhD
University of South Florida College of Medicine, Division of Allergy & Immunology
书评作者:
南佛罗里达大学医学院,变态反应和免疫学系
Mark C. Glaum 医学博士 哲学博士

Description:
This book reviews the most recent research on the role of mast cells and basophils in allergic and autoimmune diseases. Topic reviews are followed by discussion among international experts in mast cell and basophil biology.
说明:
本书总结了近期关于肥大细胞和嗜碱性粒细胞在变态反应和自身免疫性疾病中作用的研究资料。文章的结构先是对于每个课题的综述,然后是各位肥大细胞和嗜碱性粒细胞生物学国际专家的讨论内容。

Purpose:
The purpose is to provide basic researchers or clinicians with a concise, timely review of the factors and mechanisms regulating the growth, differentiation and function of mast cells and basophils. This is en ever-evolving field, therefore periodic updates in this area are needed. Emphasis is placed on new technologies used to study mast cell and basophil function, and attention is focused on how basic scientific observations can be translated into possible therapeutic applications.
目的:
本书的目的是为了给基础研究者或临床医师提供有关肥大细胞和嗜碱性粒细胞生长、分化和功能等方面的影响因素和调节机制的最新简明资料。由于这个领域的进展 日新月异,因此人们需要定期更新学习。文章重点介绍了有关肥大细胞和嗜碱性粒细胞功能研究方面的新技术,而且着重讨论了如何将基础研究成果转化成可能的临 床治疗。

Audience:
Discussion is targeted to researchers and clinicians who have an interest in mast cell and basophil biology. Specialists most likely to use this book include allergists, clinical immunologists, rheumatologists, and dermatologists. Clinical and research fellows will also find it to be an excellent review of basic mechanisms of mast cell and basophil growth, differentiation, and activation.
读者:
本书主要是面向对肥大细胞和嗜碱性粒细胞生物学感兴趣的研究者和临床医生。最可能需要本书的专家包括变态反应学家、临床免疫学家、风湿病学家和皮肤科学家。临床医生和研究人员将会发现本书对肥大细胞和嗜碱性粒细胞生长、分化和活化基本机制方面作了非常好的总结。

Features:
Each chapter is presented in the format of a topic review, which is followed by specific discussion of the topic among seminar panelists. A general discussion of the presented material is included every 3 to 5 chapters. The topics include: development of mast cells and basophils, IgE-mediated activation of mast cells and basophils, mechanisms of exocytosis, non-IgE-mediated activation and modulation of mast cells and basophils, description of mediators including those that are lipid-derived, proteases, proteoglycans and cytokines. Each chapter is well referenced and participant and subject indexes are included. The compact size of the book makes transport manageable.
特色:
每一章的格式都是先介绍某个课题的综述,然后是有关这一课题专家小组讨论的专业内容。每3-5章有一个关于这些章相关课题的总结性讨论。文章讨论的课题包 括:肥大细胞和嗜碱性粒细胞的发育,IgE介导的肥大细胞和嗜碱性粒细胞的活化,胞吐作用的机制,非IgE介导的肥大细胞和嗜碱性粒细胞的活化和调节,这 些课题中涉及到的介质包括:脂类衍生物,蛋白酶、蛋白聚糖和细胞因子等。书中的每一章都列有参考文献和主题索引,而且还列出了参与本书编写的各位人员。另 外,本书体积较小,易于携带。

Assessment:
This is an excellent review of current research in mast cell and basophil biology. The discussion sections provide unique insight from world-recognized experts in the field. This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases.
评估:
本书是关于肥大细胞和嗜碱性粒细胞生物学近期研究进展的很好的综述。书中的讨论部分从该领域世界知名专家的独特视角进行了讲述。总之,对于肥大细胞及其相关疾病感兴趣的临床医生或基础科学家来说,本书都是一本非常有用的参考资料。

PARASITES & ALLERGY
Editors: Capron, M; Trottein, F
寄生虫和变态反应
主编:Capron, M和Trottein, F

List price: $162.00 USD
Available from: Karger
定价:162.00美元
定购网址:Karger

Reviewer:
PETER DEBUSE FRACP, FRCP (LOND.)
ROYAL CHILDREN’S HOSPITAL, BRISBANE, AUSTRALIA
书评作者:
澳大利亚BRISBANE,皇家儿童医院
澳大利亚皇家内科学会 英国伦敦皇家内科医师学会会员 PETER DEBUSE

Description:
Since the 1980's, the "hygiene hypothesis" has held sway in explaining the increase in allergic disease in affluent countries and the lack of increase in underdeveloped communities. The basic concept is that T helper cells are stimulated by infections in childhood and that if they are not, a default mode stimulates the T2 helper cells concerned with the allergic process. The allergic process is often considered to have evolved largely as a measure to counter the gut infestation by protozoan parasites. Where community parasite infestation is high, epidemiologic studies show that the incidence of allergic diseases is lower than in communities with low parasite infestation.
说明:

1980以来,在解释富裕国家变态反应性疾病升高,而不发达群体没有增高这种情况时
,“卫生学假说”起 着主导地位。这个假说的基本观点就是儿童期的感染会刺激T辅助细胞,如果没有受到刺激,那么默认模式就会刺激和变态反应过程有关的Th2辅助细胞。变态反 应过程通常被认为是衡量消化道被原生动物寄生虫感染的次数的多少。和低寄生虫感染的群体相比,当群体的寄生虫感染率较高时,流行病学研究显示变态反应疾病 的发病率就很低。

The editors have assembled twelve reviews which address the complicated cellular signaling mechanisms that are involved in the phenomenon, allowing the authors to discuss the anomalies in the basic "hygiene hypothesis" and speculate on the implications for associated T1 disease states such as inflammatory bowel disease and diabetes Type 1. Nearly all the reviews use the example of schistosomiasis in their discussion, probably because of the massive and widespread prevalence in the developing world. The biology of intestinal Helminths is dealt with not only in terms of the life cycle but also in evolutionary significance.
编者综合了12篇关于卫生学假说相关现象的复杂的细胞信号传导机制的综述,这样作者不仅探讨了基本的“卫生学假说”中的异常之处,也推测了对于T1疾病状 态,如炎症性肠病和1型糖尿病等相关疾病的影响。几乎所有的综述都是以血吸虫病作为例子进行讨论,这可能是因为本病在发展中世界的发病较多,流行面积较 广。书中不仅从生命周期这一角度来讨论肠道寄生虫的生物学,而且讲到了在进化中的意义。

Purpose:
These reviews provide an up-to-date and informative discussion on signaling, proteases, and glycans as promoting molecules, the nature of white cells (natural killer, mast cells, and basophils) and importantly on Regulatory T cells.
目的:
在了解信号传导、蛋白酶和作为促进分子的葡聚糖,以及天然白细胞(自然杀伤细胞、肥大细胞和嗜碱性粒细胞),调节T细胞的重要性等方面,这些综述为大家提供了最新的、内容丰富的知识。

Audience:
I found this a fascinating book and anyone interested in biology will enjoy it. Naturally immunologists and allergists are a target audience, but general physicians – both adult and paediatric – will be interested in the speculations on novel methods of controlling inflammatory/allergic diseases.
读者:
我觉得这是一本非常引人入胜的书籍,任何对生物学感兴趣的人都会喜欢这本书的。当然,本书的主要读者还是免疫学家和变态反应学家,但不管是成人还是儿科的普通内科医生,都会对书中探讨的控制炎症/变态反应疾病的新方法感兴趣的。

Features:
The multifaceted approach to unraveling the molecular basis is well organized by the Editors so that there is a layered wealth of detail and a good deal of consensus. The tables and figures are clear and the references numerous.
特色:
编者从多个途径解释基础的分子学知识,结构组织有序。书中分层次的介绍了很多细节及大量共识性的内容。本书图表清晰,参考文献众多。

Find more allergy book reviews on the WAO Website here.
WAO网站上其它的变态反应学书评见此处

 

The World Allergy Organization's mission is to build a global alliance of allergy societies to advance excellence in clinical care, research, education and training. Visit us on the Web at http://www.worldallergy.org/

World Allergy Organization (WAO)
Secretariat
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
Email: info@worldallergy.org

You have received this message because you are a member of a WAO Member Society, you have subscribed for the monthly e-letter or had previous contact with the World Allergy Organization. If you would prefer not to receive further messages from WAO, please reply to this message with REMOVE in the subject line.

世界变态反应组织的使命是建立一个全球性的变态反应学会联盟,不断推动临床、科研、教学与培训工作的进步。欢迎您浏览我们的网站: http://www.worldallergy.org/

世界变态反应组织(WAO)秘书处
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
电子信箱:info@worldallergy.org

您因如下原因收到此次通讯:您是世界变态反应协会会员,或者您曾向世界变态反应协会订阅过电子月刊,或者您以前曾与世界变态反应协会进行过有关联系。如果您不希望继续收到来自世界变态反应协会的信息,请以删除为主题回复此邮件。



Made possible through an unrestricted educational grant from Novartis.
>
由诺华教育基金提供资助

译者:北京协和医院 顾建青    Translated by Gu jianqing MD  PUMCH Dep. of ALLERGY