WAO News and Notes - Medical Reviews
Volume 6, Issue 9 Reviews - September 2009
World Allergy Congress (WAC) 2009 - Buenos Aires, Argentina,  6-10 December 2009
Medical Journal Reviews

Juan Carlos Ivancevich, MD, in collaboration with Richard Lockey, MD, the WAO Web Editor-in-Chief, conducted these reviews of premier medical journal articles for practicing allergists. Read their top selections here, and link to the remaining reviews from the menu. You may also visit the Medical Journal Review section of the WAO Web site.

To read translations of past Medical Journal Reviews, click here.

1. Dose-response relationship of inhaled corticosteroids (ICS) and cataracts
A systematic review and meta-analysis is reported of four case-control studies of cataracts and ICS use, with a total of 46,638 cases and 146,378 controls. The primary outcome was risk of cataracts. There was a significant relationship between risk of cataracts and ICS dose, with a random effects pooled odds ratio for risk of cataracts per 1000 µg increase in daily beclomethasone dose of 1.25 (95% CI: 1.14-1.37). The risk of cataracts was increased by approximately 25% for each 1000 µg per day increase in the dose of beclomethasone or equivalent.
Editor's comment: These findings reinforce the importance of prescribing the least amount of an ICS to control asthma and screening for the presence of cataracts in older subjects with asthma and COPD.
Weatherall, M. et al., Dose-response relationship of inhaled corticosteroids and cataracts: A systematic review and meta-analysis, Respirology, 983-990, Published Online August 2, 2009. Abstract


2. Probiotic effects on incidence and duration of cold and influenza-like symptoms (ILS) in children
This DBPC (double-blind, placebo-controlled) study on 326 healthy children (3-5 years) reports on the effects of probiotic consumption during the winter season. Subjects were assigned randomly to receive placebo (N = 104), Lactobacillus acidophilus NCFM (North Carolina Food Microbiology) (N = 110), or L acidophilus NCFM in combination with Bifidobacterium animalis subsp lactis Bi-07 (N = 112), treated twice daily for 6 months. Single and combination probiotics relative to placebo significantly reduced the incidence and duration of fever, cough and rhinorrhea, antibiotic use and days absent from child care.
Editor's comment: Daily dietary probiotic supplementation may be a safe and effective way to reduce cold and ILS symptoms in children 3 to 5 years of age.
Leyer G. et al., Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children, Pediatrics, 124(2):e172-e179. Abstract


3. Unmet needs in severe chronic upper airway disease (SCUAD)
SCUAD defines patients whose symptoms are inadequately controlled despite optimal, i.e., effective, safe, and acceptable, pharmacologic treatment based on guidelines. These patients have an impaired quality-of-life, social function, sleep, and school/work performance. Severe uncontrolled allergic rhinitis, nonallergic rhinitis, chronic rhinosinusitis, aspirin exacerbated respiratory disease, and occupational airway diseases are defined as SCUADs. The group of experts who wrote this paper believes that SCUADs should be considered differently from mild chronic upper airway diseases. It reviews the state-of- the-art literature, highlighting gaps in knowledge, and proposes several areas for the better understanding, prevention, and management of SCUADs.
Editor's comment: This paper hopefully will prompt the pharmaceutical industry to increase research for SCUAD.
Bousquet J. et al., Unmet needs in severe chronic upper airway disease (SCUAD), JACI 24(3): 428-433. Abstract


All 10 reviews are posted in the literature review section of the WAO website.

WAO Journal

World Allergy Organization Journal
September 2009, Volume 2, Issue 9
ISSN: 1939-4551

This Month in the Journal



Expertise in Allergy and Immunology Can Aid Other Medical Specialties
S. Gunnar O. Johansson, MD, PhD


Clinico-immunological Analysis of Eggplant Allergy Indicates Preponderance of Allergens in the Peel
Bheemanapalli N. Harish Babu, MSc (Agri); and Yeldur P. Venkatesh, PhD


Cross-allergenicity between Pollen Grains and Their Cytoplasmic Granules on Brown Norway Rats
Oussama R. Abou Chakra, PhD; Jean-Pierre Sutra, PhD; Françoise Rogerieux, MSc; Gabriel Peltre, PhD; Hélène Sénéchal, PhD; and Ghislaine Lacroix, PhD

Detection of Fungi in Indoor Environments and Fungus-specific IgE Sensitization in Allergic Children
Mitsuhiko Nambu, MD, PhD; Hisashi Kouno, MT; Maki Aihara-Tanaka, PhD; Hideharu Shirai; and Kosuke Takatori, DVM, PhD



Eosinophils in Chronic Urticaria: Supporting or Leading Actors?
Riccardo Asero, MD; Massimo Cugno, MD; and Alberto Tedeschi, MD



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The World Allergy Journal accepts original scientific and clinically relevant information concerned with the practice of allergy and clinical immunology including state-of-the-art review articles and editorials on translational and clinical medicine. Note that the Journal will be retroactively indexed. If you have an original contribution not previously published, visit www.WAOJournal.org and click on "Instructions for Authors".

Additional Journal Reviews
  1. Obesity, Waist Size, and Prevalence of Current Asthma in Cohort Study


  2. Hypochlorite bleach, atopic sensitization, and respiratory symptoms in adults


  3. PS increases effect of TRP on childhood asthma incidence


  4. Arginase: key enzyme in the pathophysiology of allergic asthma


  5. T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma


  6. Allergic status of schoolchildren with food allergy to eggs, milk or wheat in infancy


  7. HDM-SLIT - The Role for TGF-beta and Functional Regulatory T Cells


Your global community of learning and practice for allergy and immunology! www.worldallergy.org

Medical Book Review

Urticaria and Angioedema, Second Edition
Allen P. Kaplan, Malcolm W. Greaves (Editors)
Informa Healthcare, 2009
ISBN: 9781420077841
List Price: $299.00 USD
Available at: Barnes and Noble

Roger W. Fox, MD
Professor of Medicine and Pediatrics
University of South Florida College of Medicine
Division of Allergy
Tampa, Florida USA

This 455 page book entitled "Urticaria and Angioedema" has 25 Chapters. The international authorities and authors review the basic mechanisms and cellular interactions involved in this spectrum of disorders that manifest as urticaria and angioedema and how to diagnosis and treat them.

A comprehensive compendium of clinically useful knowledge about urticaria and angioedema.

All specialists and healthcare professionals that see patients with these diseases.

The chapters review the essential knowledge required to understand the pathophysiology of different forms of urticaria and angioedema as well as how to clinically evaluate and treat them.

This textbook is essential for any physician who routinely evaluates and treats patients with these diseases, in particular, for allergists/immunologists and dermatologists.

Find more allergy book reviews on the WAO Website here.

The World Allergy Organization's mission is to be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training, as a world-wide alliance of allergy and clinical immunology societies. Visit us on the Web at www.worldallergy.org

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