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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.

Medical Journal Reviews

July 2014

1. Clinical Review. Allergic rhinitis in children.

Barr JG, Al-Reefy H, Fox AT, and Hopkins C. Allergic rhinitis in children. BMJ 2014; 349: g4153 1 July 2014. (doi:

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Editor’s comment: In this comprehensive and updated clinical review regarding allergic rhinitis in children, the authors perform a thorough review of the current literature, with particular attention to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines, produced by the World Health Organization, and from this they develop a comprehensive summary regarding the most prevalent illness in our specialty.

2. An extensive rice protein-based hydrolyzed formula is shown to be effective in the treatment of cow’s milk protein allergy.

Vandenplas Y, De Greef E, and Hauser B. An extensively hydrolysed rice protein-based formula in the management of infants with cow’s milk protein allergy: preliminary results after 1 month.  Archives of Disease in Childhood 2014; published online before print, 9 June 2014. (doi:10.1136/archdischild-2013-304727)

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Editor’s comment: Guidelines recommend extensively hydrolyzed cow’s milk protein formulas in the treatment of infants with cow’s milk allergy (CMA); however, extensively hydrolyzed rice protein infant formulas have recently become available, in this study the investigators demonstrate that it is tolerated by more than 90% of children with proven CMA with a 95% CI and thus may be a good alternative.

3. Systematic review about the evidence for epidemiological association between low levels of serum vitamin D and asthma diagnosis in children.

Rajabbik MH, Lotfi T , Alkhaled L, Fares M, Fuleihan GEH, Mroueh S, and Akl EA. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy, Asthma & Clinical Immunology 2014; 10:31, 11 June 2014. (doi:10.1186/1710-1492-10-31)

Full Text, Open Access

Editor’s comment: The authors systematically reviewed the evidence for an epidemiological association between low serum levels of vitamin D and the diagnosis of asthma in children and concluded that available evidence suggests a potential association, but high quality studies are needed to bring closure to this question.

4. Current perspectives and future directions of mucosal vaccine development.

Azegami T, Yuki Y, and Kiyono H. Challenges in mucosal vaccines for the control of infectious diseases. International Immunology 2014; accepted manuscript, published online before print, 9 June. (doi:10.1093/intimm/dxu063)

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Editor’s comment: The authors reviewed the accumulated data regarding the innate and acquired immunity of the mucosal immune system with a focus on the recent scientific and technical advancements in the development of the next generation of mucosal vaccines for the control of infectious diseases.

5. Defining asthma phenotypes on the basis of clinical and epidemiological data.

Henderson AJ. Childhood asthma phenotypes in the twenty-first century. Breathe 2014; 10(2): 100 – 108. (doi:10.1183/20734735.014613)

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Editor’s comment: The author reviewed the developing concept of asthma phenotypes in children.  He considers the implications for disease aetiology and treatment and suggests new possibilities in approaching this problem in this era of “big data”.