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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.

Medical Journal Reviews


Articles are selected for their importance to clinicians who care for patients with asthma and allergic/immunologic diseases by Juan Carlos Ivancevich, MD, WAO Web Editor-in-Chief, and John J. Oppenheimer, MD - FACAAI - FAAAAI, WAO Reviews Editor.

1. Skin Prick Test: Relating the allergen wheal response to histamine.

Dreborg S. Allergen skin prick test should be adjusted by the histamine reactivity. International Archives of Allergy and Immunology 2015;166:77-80 (doi:10.1159/000371848)


Editor’s comment: In this study the authors compared two methods of skin test interpretation – the method of Nordic Guidelines using histamine as a reference and the method of Brighton et al., not using histamine as a reference. They found that the influence of skin test assistants’ technique could be reduced when using the Nordic Guideline technique.

2. Microbial exposure during early life may prevent, or reduce, the risk of allergy development.

Hesselmar B, Hicke-Roberts A, Wennergren G. Allergy in children in hand versus machine dishwashing. Pediatrics 2015;135(3):e590-e597. (doi:10.1542/peds.2014-2968)

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Editor’s comment: In families who use hand dishwashing, allergic disease in children is less common than in children from families who use machine dishwashing. The authors speculate that a less-efficient dishwashing via the hand dishwashing method may induce tolerance secondary to increased microbial exposure.

3. Improvements in air quality over time are associated with better development of lung function in children.

Gauderman WJ, Urman R, Avol E, Berhane K, McConnell R et al. Association of improved air quality with lung development in children. New England Journal of Medicine 2015;372:905-913. (doi:10.1056/NEJMoa1414123)

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Editor’s comment: The authors found that long-term improvements in air quality were associated with statistically and clinically significant positive effects on lung-function growth in boys and girls, Hispanic white and non-Hispanic white children, as well as those with asthma and without asthma.  This suggests that all children have the potential to benefit from improvement in air quality.

4. Managing asthma and exercise-induced bronchoconstriction in athletes.

Boulet L-P and O’Byrne PM. Asthma and exercise-induced bronchoconstriction in athletes. New England Journal of Medicine 2015;372:641-648. (doi:10.1056/NEJMra1407552)


Editor’s comment: The authors reviewed the current management of asthma and exercise-induced bronchoconstriction in athletes, particularly in athletes who engage in endurance sports, and they provide specific recommendations for high-level athletes.

5. New clinical practice guideline on chronic urticaria and angioedema by the British Society for Allergy and Clinical Immunology.

Powell RJ, Leech SC, Till S, Huber PAJ, Nasser SM, Clark AT. BSACI guideline for the management of chronic urticaria and angioedema. 2015;45(3):547-565. (doi:10.1111/cea.12494)

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Editor’s comment: The authors concluded that the early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy.