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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.

Medical Journal Reviews

February 2015

Articles are selected for their importance to clinicians who care for patients with asthma and allergic/immunologic diseases by Juan Carlos Ivancevich, MD, WAO Web Editor-in-Chief, and John J. Oppenheimer, MD, FACAAI, FAAAAI, WAO Reviews Editor.

1. Development of allergies and asthma is not related to cleaning activities.

Weber J, Illi S, Nowak D, Schierl R, Holst O, von Mutius E, and Ege MJ. Asthma and the Hygiene Hypothesis – Does cleanliness matter? American Journal of Respiratory and Critical Care Medicine 2015; published online before print, 13 January. (doi:10.1164/rccm.201410-1899OC)


Editor’s comment: The authors concluded that neither personal nor home cleanliness were associated with protection from asthma and allergies. Other microbial components in house dust not affected by personal hygiene are likely to play a role.

2. Sensitization to aminopenicillin may develop within infectious mononucleosis.

Ónodi-Nagy K, Kinyó A, Meszes A, Garaczi E, Kemény L, and Bata-Csörgo Z. Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization. Allergy, Asthma & Clinical Immunology 2015; 11(1). (doi:10.1186/1710-1492-11-1)

Full Text, Open Access

Editor’s comment: The aim of this study was to determine whether true amoxicillin sensitization could develop in patients with infectious mononucleosis who developed maculopapular exanthems following treatment with aminopenicillin. Like other infectious illnesses, they found that drug sensitization can indeed occur during the infection. Lastly, they demonstrate that in vitro testing is not sensitive enough in determining drug sensitization to penicillin but could be confirmed with skin testing.

3. Biologic medications in asthma and allergic disease.

Fajt, ML and Wenzel SE. Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care. Journal of Allergy and Clinical Immunology 2015; 135(2): 299-301. (doi:

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Editor’s comment: This review analyzes randomized double-blind, placebo-controlled trials of molecularly targeted therapies in defined allergic disease and asthma phenotypes and shows that therapies targeting the canonical type 2 cytokines IL-4, IL-5, and IL-13 show consistent efficacy, especially in asthmatic patients with evidence of TH2/type 2 inflammation.

4. Opportunities and challenges that have arisen from electronic health records (EHRs).

Kuhn T, Basch P, Barr M, and Yackel T. Clinical Documentation in the 21st Century: Executive Summary of a Policy Position Paper from the American College of Physicians. Annals of Internal Medicine 2015; published online before print, 13 January. (doi:10.7326/M14-2128)

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Editor’s comment: In this document, the Medical Informatics Committee of the American College of Physicians review the literature regarding clinical documentation, in an effort to clarify the broad range of issues surrounding clinical documentation, and they suggest a path forward, such that care and clinical documentation in the 21st century will “best serve” the needs of our patients.

5. New clinical practice guideline on allergic rhinitis.

Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM et al. Clinical Practice Guideline: Allergic Rhinitis. Otolaryngology – Head and Neck Surgery 2015; 152(1): S1-S43. (doi:10.1177/0194599814561600)

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Editor’s comment: Following an extensive evidence-based review of the literature, a multidisciplinary panel of 21 experts created a series of actionable recommendations regarding the evaluation and treatment of allergic rhinitis.