Medical Journal Reviews
1. IL-4, IL-13, and thymic stromal lymphopoietin play a key role in allergic disease.
Romeo MJ, Agrawal R, Pomés A, Woodfolk JA. A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease. The Journal of Allergy and Clinical Immunology 2014; 133(4): 952-960. (doi:10.1016/j.jaci.2013.08.006)
Editor’s comment: The authors describe the characteristics of receptors for IL-4, IL-13, and thymic stromal lymphopoietin and their respective ligands from a structure-function perspective detailing the mechanisms of receptor complex assembly, the interrelated nature of these receptors, and their effect on allergic inflammation. They also highlight current and emerging treatments that target TH2-promoting receptor complexes.
2. Most asthma begins in the nose and involves allergy and infection..
Tarlo SM and Lemiere C. Occupational asthma. Scadding GK. Allergens, germs and asthma. The Clinical Respiratory Journal; 8(2); Accepted article, published online before print. (doi:10.1111/crj.12128).
Editor’s comment: The author explores asthma pathogenesis using data from upper and lower airways published in English language papers on human asthma and nasal polyp subjects from 1990 onwards selecting high quality studies in established journals. The combination of atopy and infection suggests new possibilities for therapy.
3. Prevalence of allergic sensitization in Canadian chronic rhinosinusitis patients.
Green BJ, Beezhold DH, Gallinger Z, Barron CS, Melvin R, Bledsoe TA, Kashon ML, Sussman GL. Allergic sensitization in Canadian chronic rhinosinusitis patients. Allergy Asthma & Clinical Immunology 2014; 10:15. 25 March 2014. (doi:10.1186/1710-1492-10-15).
Editor’s comment: The authors used skin prick test and specific immunoglobulin E and G titers to regionally relevant allergens in order to determine the prevalence of allergic sensitization in chronic rhinosinusitis patients. Their results suggest that A. alternata sensitization is associated with chronic rhinosinusitis, and they additionally highlight the contribution of other regionally important allergens including cat and ragweed.
4. Airway inflammatory biomarkers as valuable tools in diagnosis and management of asthma.
Fatemi F, Sadroddiny E, Gheibi A , Farsani TM, and Kardar GA. Biomolecular markers in assessment and treatment of asthma. Respirology 2014; published online before print, 3 April. (doi:10.1111/resp.12284)
Editor’s comment:In this comprehensive review the authors analyze molecular markers of airways inflammation that show promise in providing non-invasive techniques that might facilitate the detection of disease phenotypes as well as measure therapeutic efficacy.
5. Possible role of coagulation in chronic urticaria.
Tedeschi A, Kolkhir P, Asero R, Pogorelov D, Olisova O, Kochergin N, and Cugno M. Chronic urticaria and coagulation: pathophysiological and clinical aspects. Allergy 2014; published online before print, 27 March. (doi:10.1111/all.12389)
Editor’s comment: This excellent review summarizes the available data on the possible contribution of coagulation to the pathophysiology of chronic urticaria focusing on clinical aspects and possible future therapeutic developments.