Medical Journal Reviews
1. Interventions to manage immediate and long-term symptoms of food allergy and promote desensitization/tolerance.
de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T et al. Acute and long-term management of food allergy: systematic review. Allergy 2014; 69(2): 159-167. (doi:10.1111/all.12314)
Editor’s comment: This systematic review summarizes the evidence about the immediate management of reactions and the longer-term approaches to minimize adverse outcomes in patients with food allergy. The authors concluded that the evidence base about acute and longer-term management is weak and needs to be strengthened as a matter of priority.
2. Update on food allergy.
Sicherer SH and Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. The Journal of Allergy and Clinical Immunology 2014; 133(2): 291-307.
Editor’s comment: This comprehensive review focuses on advances and updates in the epidemiology, pathogenesis, diagnosis, and treatment of food allergy over the past 3 years. The authors highlight recent clinical observations and advances regarding the prevention, diagnosis, and management of food allergy that apply now, and they speculate on those that may be important in the future.
3. Efficacy of oral immunotherapy for the desensitization of children with allergy to peanuts.
Anagnostou K, Islam S, King Y, Foley L, Pasea L et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. The Lancet 2014; Article in press; published online before print (30 January) (doi:10.1016/S0140-673662301-6)
Editor’s comment: The authors concluded that oral immunotherapy successfully induced desensitization in most children within the study population with peanut allergy of any severity, by inducing a clinically meaningful increase in the threshold dose to peanut challenge. There was also a good safety profile.
4. A better understanding and management of patients with hypersensitivity drug reactions (HDRs).
Fernandez TD, Mayorga C, Guéant JL, Blanca M, Cornejo-Garcia Ja. Contributions of pharmacogenetics and transcriptomics to the understanding of the hypersensitivity drug reactions. Allergy 2014; 69(2):150-158. (doi:10.1111/all12304)
Editor’s comment: In this excellent review the authors discuss advances in our knowledge of the pharmacogenetics, immunology and transcriptomics involved in hypersensitivity drug reactions.