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World Allergy Organization
WAO's mission: To be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies.


WAO Reviews - Editors' Choice

Posted: July 2011

Each month as a service to WAO members and other readers, the editors select recently published articles for their importance to clinicians who care for patients with asthma and allergic/immunologic diseases. Please enjoy this month's selections by Juan Carlos Ivancevich, MD, WAO Web Editor-in-Chief, and Phillip Lieberman, MD, WAO Reviews Editor.

1. Reevaluating the use of natural latex gloves in medical practice.

Palosuo T, Antoniadou I, Gottrup F et al. Latex Medical Gloves: Time for a Reappraisal. International Archives of Allergy and Immunology 2011; 156(3):234-246.
Full text, free access

Editor's comment: The use of low-protein, low-allergenic, powder-free gloves is associated with a significant decrease in the prevalence of type I allergic reactions to natural rubber latex among healthcare workers.

2. Eosinophilic responses: a feared and devastating stent complication.

Kounis NG, Giannopoulos S, Tsigkas GG et al. Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome. International Journal of Cardiology 2011; Article in Press
Abstract

Editor's comment: The drug-eluting stents containing metal substrates and drugs that constitute complex antigens within the coronary arteries produce a chronic and persistent inflammatory action capable of inducing Kounis syndrome and stent thrombosis.

3. Association between type IV allergy and cancer.

Engkilde K, Thyssen JP, Menné T et al. Association between cancer and contact allergy: a linkage study. BMJ Open July 2011 [doi:10.1136/bmjopen-2011-000084]
Full text, open access

Editor's comment: The associations between cancer and allergies are mostly inverse. This relationship has been postulated to be due to the fact that immune mechanisms underlying atopy may be active in immune surveillance.

4. Allergic outcomes comparison between infants fed with conventional cow's milk formula, a partially hydrolyzed formula and a soy formula.

Lowe AJ, Hosking CS, Bennett CM et al. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A randomized controlled trial. The Journal of Allergy and Clinical Immunology June 2011; Article in Press [doi: 10.1016/j.jaci.2010.05.006]
Abstract

Editor's comment: Despite recommendations to use partially hydrolyzed milk formula to prevent the development of allergy in early childhood, this paper shows that neither the partially hydrolyzed milk formula or soy formula are able to prevent the development of allergy.

5. Early-life factors and the development of rhinitis in Europe.

Matheson MC, Dharmage SC, Abramson MC et al. Early-life risk factors and incidence of rhinitis: Results from the European Community Respiratory Health Study-an international population-based cohort study. The Journal of Allergy and Clinical Immunology July 2011; Article in Press [doi: 10.1016/j.jaci.2011.05.039]
Abstract

Editor's comment: This European large population study provides evidence that gender is related to rhinitis in atopic individuals and certain childhood exposures can influence the development of rhinitis at different stages of life.

6. Urinary eosinophil protein-X (u-EPX) and other biomarkers in healthy but allergy-risk newborns.

Krogsgaard Chawes BL, Bønnelykke K, Bisgaard H. Elevated Eosinophil Protein X in Urine from Healthy Neonates Precedes Development of Atopy in the First 6 Years of Life. American Journal of Respiratory and Critical Care Medicine; June 2011; Published online ahead of print [doi: 10.1164/rccm.201101-0111OC]
Abstract
Summary at ScienceDaily

Editor's comment: Elevated levels of u-EPX at 1 month are significantly associated with the development of allergic sensitization, nasal eosinophilia and eczema. Thus measurement of this protein may have clinical utility as an early marker of atopy.

7. Drug provocation tests for diagnostic purposes: patient´s perceptions.

Gomes ER, Kvedariene V, Demoly P, Bousquet P-J. Patients' Satisfaction with Diagnostic Drug Provocation Tests and Perception of Its Usefulness. International Archives of Allergy and Immunology 2011; 156(3): 333-338.
Abstract

Editor's comment: Most patients are satisfied with drug provocation tests regardless of the results and the country they were performed.

8. Potential use of free amino acids in allergy treatment.

Deus-de-Oliveira N, Felix SP, Carrielo-Gama C et al. Identification of Critical Amino Acids in the IgE Epitopes of Ric c 1 and Ric c 3 and the Application of Glutamic Acid as an IgE Blocker. PLoS ONE 2011; 6(6):e21455 [doi: 10.1371/journal.pone.0021455]
Full text, open access

Editor's comment: Glutamic acid decreases IgE binding to allergens and allergen induced mast cell degranulation and histamine release. These findings may offer a new platform for the treatment of allergic disease.

9. Basophils may play an important role in a variety of inflammatory skin diseases.

Ito Y, Satoh T, Takayama K et al. Basophil recruitment and activation in inflammatory skin diseases. Allergy 2011; 66(8):1107-1113.
Abstract

Editor's comment: Basophils are detected in skin lesions of atopic dermatitis, prurigo, urticaria, bullous pemphigoid, drug eruptions, eosinophilic pustular folliculitis, insect bites, scabies, Henoch- Schonlein purpura and dermatomyositis. Further studies are needed to discern the contribution of basophils to the pathogenesis of the disease.

10. Utility of patch testing in fixed drug eruptions.

Andrade P, Brinca A, Margarida G. Patch testing in fixed drug eruptions-a 20-year review. Contact Dermatitis June 2011; Published online before print [doi: 10.1111/j.1600-0536.2011.01946.x]
Abstract

Editor's comment: The results of skin patch testing confirmed the clinical suspicions of the investigators in this study as to the cause of drug eruptions. Patch testing also identified the drug in almost half of the patients. Patch tests were especially helpful in investigating fixed drug eruptions due to nonsteroidal anti-inflammatory agents.