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WAO Medical Book Reviews

June 2015

Immunology of Aging
Edited By: Ahmad Massoud, PharmD, MPH, PhD and Nima Rezaei, MD, MSc, PhD
ISBN: 978-3-642-39494-2 (Hardcover)
eISBN: 978-3-642-39495-9 (Online)

$146.00 (Print)
$109.00 (Online)
Available from: Springer


Mario Rodenas, MD
Clinician, Yale University School of Medicine
Division of Allergy and Clinical Immunology
Connecticut, USA


Immunology of Aging is a unique resource for those interested in understanding the changes in immune function resulting from the aging process.


This book provides a review of current knowledge regarding the cellular and molecular aspects of the aging immune system and their clinical relevance.


The text is divided into 26 chapters. The first three chapters are related and present the readers with an introduction on the aging of the immune system including the role of stem cells.

The reader is then familiarized with the different theories of aging in chapter four. The following four chapters outline cellular mechanisms that constitute the innate response during the aging process. Over the next six chapters, changes in the adaptive immune system are reviewed, with a principal focus on T-cell mediated immunity.

The authors then highlight the role of microRNAs in immunosenescence and the immunogenetics of aging. The latter third of the book examines the susceptibility of the elderly to infections with particular focus on influenza and optimization of the response to vaccinations. The effects of nutrition and diet, and oxidative stress are explored, and figures and diagrams in the text support many of the concepts outlined.

Immediately following is a review of the skin: structure, immune system and immunological responses specific to the skin as well as aging of the skin and age-related changes in immune function.

Lastly, the effect of physical activity on the immune system is discussed.

The overall number of figures, diagrams, tables, and illustrations in this book is limited which simply requires more reading of text to gain full information presented.

Assessment and Audience: 

This book provides a general overview of immunosenescence and its consequences. Although this book traverses several disciplines, including infectious disease and dermatology, those in the fields of immunology and geriatrics will likely find this resource most valuable.