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WAO Medical Book Reviews

March 2015

Asthma: Comorbidities, Coexisting Conditions, and Differential Diagnosis
Edited By: Richard F Lockey and Dennis K Ledford with the World Allergy Organization
ISBN: 978-0-19-991806-5
ISBN-13: 978-0199918065
ISBN-10: 0199918066
Copyright 2014 World Allergy Organization

Available from: Oxford University Press
List price: Hard cover $78.50 / £52.00

Reviewer
Alexandru Corlateanu, MD, PhD
Vice-Dean of Faculty Medicine
Associate Professor of Respiratory Medicine
Nicolae Testemitanu State University of Medicine
Chisinau, Moldova

Description
Asthma Comorbidities, Coexisting Conditions, & Differential Diagnosis is dedicated to one of the hot topics in respiratory medicine. Multiple comorbidities can be associated with asthma and influence its clinical expression, although their specific impact remains to be characterized. Asthma comorbidities are increasingly rec­ognized as important factors to document in asthma patients, as they may influence disease management and control.

This book provides a comprehensive review of the most frequent contributing comorbid condi­tions reported in asthmatic patients: COPD, rhinitis, sinusitis, gastroesophageal reflux disease (GERD), obstructive sleep apnea (OSA), metabolic disorders, psychopathologies, and more.

Purpose
The purpose of this book is to help the respiratory physician and research scientist to better understand the origin of asthma comorbidities and the real impact on the natural history and severity of asthma and implications for asthma therapy, as well as to detect the mechanisms by which they could affect asthma.

Features
The contents are organized into 33 chapters, which are structured in 11 sections: immunologic, pulmonary, cardiac and cardiovascular, upper/extrathoracic airway, gastrointestinal, metabolic, psychological issues, exercise, environmental and population effects, age and food.

Multiple comorbidities are frequently associated with asthma and may impact its clinical expression and severity. Comorbidities may influence asthma in various ways. They may influence asthma phenotypes. Sometimes they can share similar pathophysiological mechanisms. Comorbidities can impact asthma through a specific environmental exposure. Moreover, they can affect the diagnosis, assessment of control, and efficacy or adherence to therapy.

Assessment and Audience
As a comprehensive overview of asthma comorbidities, this book presents a new step in identifying mechanisms of links between asthma and its comorbidities, and it provides an updated holistic approach to the treatment of asthma and its comorbidities. This book will be useful to researchers and to clinicians.