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WAO Medical Book Reviews

May 2015

Mouse Models of Allergic Disease: Methods and Protocols
Edited by Irving C. Allen
ISBN:978-1-62703-495-1 (Hardcover)
eISBN 978-1-62703-497-8 (Online)

$139.00 USD / €126.77 EUR / £90.74 GBP (Print)
$109.00 USD / €99.40 EUR / £71.16 GBP (Online)
Available from: Springer

Sandeep Kumar, PhD
Department of Pharma & Therapeutics|
Roswell Park Cancer Institute
Buffalo, New York, USA

The book entitled Mouse models of allergic disease: Methods and protocols is an excellent collection of the key reviews that explore various basic and experimental aspects of mouse models in allergy and asthma research. This book is a beautiful contribution by leaders of the field which is useful for both novices and experts. This is a unique work that is available rarely. This book has everything essential for the use of mouse models in allergy and asthma research. This book is written in an easy flow manner, with interconnecting and self explanatory chapters with references from renowned journals. This valuable book contains 24 chapters that may serve as a pivotal tool to crystallize the basic and advanced knowledge behind the use of mouse models in allergy research. Together, this book is a collection of beautifully written chapters that are suitable to explore in-depth use of mouse models to understand allergic disease.

The key beauty of this excellent contribution is its in-depth insights on various aspects of mouse models in allergy and asthma research. Undoubtedly, this text has capability to satisfy almost every aspect of mouse use in allergy and asthma research. The detailed and systematic presentations of several protocols and methods are helpful in understanding basics of the subjects. In spite of being an early edition, this book is full of essential components required for planning, designing and executing mouse use in asthma and allergy and almost free from lacuna.

The book is a recommended reference book for trainees, clinician as well as basic researchers. Texts are written in such a way that it is suitable for the early career researcher well as well senior researchers. Considering its impact, this contribution can be included in immunology courses of universities to strengthen the basics and experimental approaches behind the use of mouse models in allergic diseases.

The text comprises 24 chapters that are sufficiently dealing with every aspect of mouse use in allergy research. This book has various sections starting from the use of transgenic mouse model to generation of bone marrow and fetal liver chimeric mice in allergic research. Each chapter has elaborated protocols and methods that are sufficient to design and perform experimentations, even for early career researchers. For example in chapter 1, authors have reported each and every aspect behind the use of transgenic mouse model including experimental details for generation of vasectomized male mice, generation of pseudo pregnant females or donor females, harvesting embryo for microinjection, microinjection of DNA, and surgical transfer of embryo, etc. The next chapters include details about pulmonary antigen presenting cells, T- and B- cell functions in allergic diseases, role of eosinophils, bone marrow derived macrophages, airway epithelial cells, mast cells, IgE and anti IgE, induction of systemic anaphylaxis, contact dermatitis, allergic rhinitis, allergic airways disease with house dust mite allergens, allergic fungal asthma, PAMPs and DAMPs in allergic exacerbations models. This book further provides an in-depth basic and experimental detail about Clara epithelial cell depletion in the lungs, mouse model for evaluating the contribution of fibrocytes and myofibroblast on airways remodeling in allergic asthma. This book also encompasses airway hypersensitivity in murine tracheal ring, use of cockroach antigen model for acute asthma to determine the immunomodulary role of early exposure to gastrointestinal infections. Furthermore, profiling of gene expression in allergy and use of flowcytometry add another dimension to this text.

Mouse models of allergic disease: Methods and protocols, edited by Irving C. Allen, is one of the most useful texts on use of mouse model in allergic research. This is a must read book for trainees, clinicians and researchers engaged in the study of allergy related manifestations. Undoubtedly, this book will provide an in-depth understanding regarding the use of mouse in allergic research. Using this invaluable text, various key phenomena behind allergic reactions can be explored.