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WAO Medical Book Reviews

Posted: April 13, 2016

IgE Antibodies: Generation and Function
Edited by: Juan J. Lafaille. Maria A. Curotto de Lafaille
ISBN 978-3-319-13724-7
eISBN 978-3-319-13725-4
DOI: 10.1007/978-3-319-13725-4

$149.00 USD / €132.10 EUR (eBook)
$189.00 USD / €189.91 EUR (Hardcover)
Available from: Springer

Paola de Baro-Alvarez, MD
Pediatric Clinical Allergist and Immunologist
Mexico City, Mexico

In recent years, prevention of allergy has become the new a major concern for future parents and a frequent topic for debate among physicians. The world of allergy involves many diseases such as asthma, rhinitis, dermatitis, anaphylaxis, urticaria, angioedema and conjunctivitis that typically involve type I hypersensitivity. An IgE-mediated response begins with the release of preformed mediators such as histamine, heparin, lipid metabolites, proteases, chemokines and cytokines from cytoplasmic granules that induce smooth muscle contraction, increased vascular permeability, epithelial mucus secretion and local inflammation, all of which cause the signs and symptoms seen during the acute allergic response.

IgE Antibodies: Generation and Function is a collaboration of two expert scientists from the United States and Singapore who not only teach and explain what we already know about IgE, but excite the reader about the broad spectrum of other functions of IgE that have been identified and studied in recent years.

The book can be used to understand the differentiation, class switch recombination and production of IgE, but it also focuses on the spectrum of IgE functions that are not so commonly known, such as the antihelminthic response and anti-tumor defenses, and how they may be exploited for prevention and therapeutics.

IgE Antibodies: Generation and Function is elegantly organized, divided into six chapters. The authors start from the beginning, teaching or reviewing the biological and molecular basics, capturing the reader’s full attention into the new studies and features of IgE.

The first two chapters summarize the biology of IgE production, the IgE-producing cell differentiation, IgE memory responses and the molecular mechanisms of class switch recombination during B cell ontogeny. These topics are complicated, so it is important to consider that a diagram may help the reader better understand the theme.

After understanding that the IgE-antigen interaction is the major trigger of acute allergic reactions, Chapter three discusses IgE as an ideal treatment target. The authors describes the function, receptors, structure, interactions and therapeutic strategies for asthma, allergic rhinitis and chronic idiopathic urticaria. Chapter four focuses on the recent advances in understanding how the high affinity IgE receptor participates in shaping the pathophysiologic response to environmental stimuli.

Chapter five examines the evidence for the similarities between responses to helminth infections and allergic disorders, and discusses the importance of developing new diagnostic methods and treatments for allergic disorders in third world countries. The final chapter reviews how IgE-based approaches have been shown to be effective in models of cancer, suggesting the potential use in humans.

Assessment and Audience
This book is a comprehensive, ideal resource for the allergologist, internist/general practitioner, oncologist, pediatrician, as well as the clinical laboratory-based allergologist and immunologist.

Why read this book? How will it impact my practice?
Reading this book helps us review the basics, recognizing the role of the high affinity IgE receptor and all the surrounding characteristics that shape the allergic response. Most importantly, this book delves into the new applications of IgE-based therapeutics for helminth infections and cancer.

Every kind of knowledge helps us achieve a better medical practice.