WAO Medical Book Reviews
Posted: August 8, 2016
COPD Clinical Perspectives
Edited by Ralph J. Panos
Online Edition Published by InTech on 16 July 2014
InTech Copyright Policy
Published under the Creative Commons Attribution 3.0 Unported (CC BY 3.0 License)
Free, Open Access for Online Edition
Hardcover: $150 USD / €138 EUR
Available from: InTech
Alexandru Corlateanu, MD, PhD
Vice-Dean of Faculty Medicine
Associate Professor of Respiratory Medicine
Nicolae Testemitanu State University of Medicine
Chronic obstructive pulmonary disease (COPD) remains a leading cause of death all over the world. At the moment COPD is the fourth leading cause of mortality and chronic morbidity at the global level.
COPD Clinical Perspectives provides a comprehensive review of diagnostic methods and overlap syndromes between COPD and asthma and obstructive sleep apnea, also there are chapters dedicated to alpha-1 antitrypsin deficiency and its treatment.
The purpose of this book is to help the respiratory physician to better understand the natural history and severity of COPD, comorbidities, alpha-1 antitrypsin deficiency, and implications for COPD therapy.
The contents are organized into seven chapters, which are dedicated to the functional evaluation of COPD, overlap syndromes between COPD and asthma, obstructive sleep apnea and alpha-1 antitrypsin deficiency and its treatment.
Unopposed neutrophil elastase activity within the pulmonary interstitium with resultant connective tissue destruction remains an important contributor to the pathogenesis of emphysema, but recent evidence suggests a more complicated cascade of proteolytic and inflammatory factors as the cause of COPD in alpha-1 antitrypsin deficiency. In addition, neutrophil elastase has been implicated in the mucus hypersecretion associated with chronic bronchitis.
Assessment and Audience
A comprehensive overview of diagnostic methods, alpha-1 antitrypsin deficiency, and overlap syndromes represents a new step to better understanding the origin of COPD and to more efficient management of this disease. This book will be useful to both researchers and to clinicians.