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WAO Medical Book Reviews

Posted: January 12, 2016

Cutaneous Drug Eruptions
Diagnosis, Histopathology and Therapy
Edited by: John C. Hall, Brian J. Hall|
ISBN 978-1-4471-6728-0|
eISBN 978-1-4471-6729-7
DOI: 10.1007/978-1-4471-6729-7

$130.13 USD / €118.99 EUR (eBook)
$159.20 USD / € 145.59 EUR (Hardcover)
Available from: Springer

Alberto Alvarez-Perea, MD, PhD
Servicio de Alergia
Hospital Materno Infantil Gregorio Marañón, Madrid, Spain

With the increase of life expectancy and the development of novel therapeutic options for diseases, the use of medications in the general population is increasing. Most notably, chronic diseases in the elderly and more complex approaches to patients in the pediatric ages are reasons that explain polymedication in patients of all ages.

With this undeniable phenomenon, the approach to cutaneous drug eruptions is becoming a more pressing burden for clinicians and pathologists alike both in the inpatient and outpatient environment. This book describes the pathophysiology of different drug rashes of different etiology with a special insight into drug hypersensitivity reactions.

The differential diagnosis of hypersensitivity reactions from other adverse reactions and cutaneous diseases requires a multidisciplinary approach in order to enhance therapy and prevent morbidity.

The book is organized into seven different parts. The first part, chapters 1-4, is an introductory overview, covering the basic aspects of skin and drug interaction, including the immunology, histopathology, and the diagnostic and therapeutic approach.

The second part, the longest section in the book, focuses on the different types of non-life-threatening drug skin reactions. This includes a discussion of morbilliform eruptions, drug-induced urticaria, vasculitis, photosensitivity, and fixed drug reactions. This section also includes a section on dermatitis that may interact with or be exacerbated by drug reactions. A brief third part is dedicated to drug reactions involving the appendages.

The fourth part of the book involves life-threatening skin reactions, such as Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis or Hypersensitivity Syndrome. Part five focuses on drugs that are less likely to be the cause of the adverse drug reaction e.g., anticoagulants, antiepileptics, cytostatics, tyrosin kinase, BRAF inhibitors, corticosteroids and retinoids. There is one chapter dedicated to the effects of certain therapies used for the treatment of skin cancer. 

Part six gives a glimpse of dermatosis associated with neutrophils (Sweet’s syndrome, bowel-associated dermatosis syndrome, erythema marginatum, and neutrophilic hidradenitis) and granulomatous nodules, e.g., methotrexate. Finally, the seventh part is dedicated to characteristics of adverse drug reactions in adults and children diagnosed to have Human Immunodeficiency Virus.

Assessment and Audience
Those physicians (allergists, dermatologists, pathologists, etc.) who desire a more in-depth look at the interaction of drugs and the skin, as well as the underlying mechanisms that lead to cutaneous drug eruptions, will find in this book a comprehensive and up-to-date valuable medical reference.