What Is New in Severe Asthma Research

View Archived Reviews
Christina E Ciaccio, MD, MSc

Christina E Ciaccio, MD, MSc
Assistant Professor of Pediatrics
University of Chicago Medicine
Comer Children’s Hospital
Chicago, Illinois, United States

Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations

This study explored the phenotypic characteristics of adults and children with exacerbation prone asthma (EPA) using data collected in the SARP-3 cohort.  Nonsmokers ages 6 and up were recruited for this study which favored those with more severe asthma.  Exacerbations were determined by self-reported use of oral corticosteroids, hospitalizations, and emergency department utilization.  Of the 709 participants in this 173 (24%) were determined to have EPA.  Although frequency of exacerbation was correlated to severity of disease, 37% had severe disease and no exacerbations and 12% with EPA did not meet criteria for having severe disease.  Those with EPA had more controller medications overall and worse ACT scores.  Those with EPA also had the worst lung function.  Median levels of eosinophils did not differ across severity categories, but adults with EPA had lower overall total IgE and fewer positive specific IgEs.  Those with EPA also had a higher frequency of co-morbid conditions, including hypertension, obstructive sleep apnea, diabetes mellitus, and osteoporosis, but not coronary artery disease.  As expected, they did have a higher incidence of chronic sinusitis and GERD.  Although these data, overall, are not surprising, phenotypic characterization of those with EPA has been under reported until now.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR et al.; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med 2017; 195(3):302-313. (doi: 10.1164/rccm.201602-0419OC) PMID: 27556234



Last updated: Friday, May 19th, 2017