News Release

EMBARGOED FOR RELEASE
Wednesday, 7 December 2011
Media Contact:

Sofia Dorsano, sdorsano@worldallergy.org

Note to media: See abstract 4172

Blocking of keratinocytic TSLP may limit epicutaneous sensitization
and prevent atopic march

CANCÚN – Juan Manuel Leyva Castillo, and colleagues from Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC, Strasbourg, France), today presented their work on the role of the skin in the initiation of the development of allergic respiratory symptoms.

Atopic dermatitis (AD or eczema) often precedes the development of asthma and allergic rhinitis in atopic subjects, a phenomenon known as the atopic march. An important role of epicutaneous sensitization has been recognized in this context, the factors involved remain poorly understood. Previous studies by the same investigators using mouse models have shown that induced over-expression of thymic stromal lymphopoietin (TSLP) in the superficial skin cells called keratinocytes not only triggers AD but also aggravates experimental asthma induced by systemic sensitization and airway challenge by ovalbumin (OVA) suggesting that TSLP represents an important factor linking AD to asthma.

The current study revealed that keratinocyte TSLP depleted mice develop a less severe airway allergic inflammation and a reduced airway hyperresponsiveness after epicutaneous sensitization. In contrast, overproduction of keratinocytic TSLP boosts the epicutaneous sensitization and triggers an aggravated asthma.
According to Professor Yehia El-Gamal, of the Children’s Hospital, Ain Shams University in Cairo, Egypt, “This shows an important role for keratinocytic TSLP in developing epicutaneous sensitization, generating allergic skin inflammation, and triggering the atopic march. Thus, blocking the expression or activity of keratinocytic TSLP might be helpful to limit epicutaneous sensitization and prevent the atopic march.”

This study is supported by CNRS, INSERM, ARI and ANR projects (07-PHYSIO-002–01 and JCJC-1106-01).

About the XXII World Allergy Congress
The World Allergy Congress is the biennial scientific meeting of the World Allergy Organization. Meeting attendees gather to learn about the most recent discoveries in allergy, asthma and immunology research and advances in treatment. More than 3,500 physicians and medical professionals from 85 countries will be able to view over 716 scientific abstracts submitted by clinicians from around the world.

About the World Allergy Organization
The World Allergy Organization (WAO) is an international alliance of 89 regional and national allergy, asthma and immunology societies. Through collaboration with its Member Societies WAO provides a wide range of educational and outreach programs, symposia and lectureships to allergists/immunologists around the world and conducts initiatives related to clinical practice, service provision, and physical training in order to better understand and address the challenges facing allergists/immunologists worldwide. For more information, visit www.worldallergy.org.

                                                                       ###