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David B. Peden, MD, MS

Dr. Peden is the Harry S. Andrews Professor of Pediatrics, Medicine, and Microbiology/Immunology and serves as the Chief of the Division of Pediatric Allergy, Immunology, and Rheumatology; Director of the Center for Environmental Medicine, Asthma & Lung Biology; and Senior Associate Dean for Translational Research for the University of North Carolina (UNC) School of Medicine. Dr. Peden received his Doctor of Medicine and Master of Science in Pharmacology and Toxicology degrees from West Virginia University (WVU). He also completed his residency and chief residency in Pediatrics at WVU Medical Center. Following residency, Dr. Peden completed an allergy/immunology fellowship at the National Institutes of Health’s National Institute of Allergy and Infectious Diseases in Bethesda, MD.

Research: Dr. Peden has extensive expertise in translational research, emphasizing Phase I and II safety and proof of concept studies, using allergen, endotoxin, and pollutant challenge models for studies of asthma, airway disease and clearance, allergic disease, and COPD. These studies focus on identifying or confirming biological determinants of airway response, testing wearable pollutant and physiologic sensors, and assessing investigational agents for airway and allergic disease, including anakinra, hypertonic saline, gamma tocopherol, allergen  immunotherapy, and tezepelumab. Dr. Peden serves as the principal investigator (PI) or site PI for these studies and is the sponsor-investigator for six IND applications. Dr. Peden is the IND sponsor investigator for the multi-site NHLBI PreCISE asthma study, testing precision medicine approaches for novel agents in asthma. He is a key investigator on the team from the UNC Collaborative Studies Coordinating Center, which is the Data and Modeling Coordinating Center for PreCISE, and a member of the PreCISE Executive and Steering Committees.

Dr. Peden is also medical director for two other research programs. One is the National Science Foundation Nanosystems Engineering Research Center for Advanced Self-Sustaining Integrated Sensor Technologies (ASSIST) based at North Carolina State University, which is dedicated to developing and testing wearable sensors for physiologic measures and environmental exposures. The other is the NIH/NCATS funded Biomedical Data Translator (BDT) program, which is comprised of a nationwide network of data teams, which includes the UNC BDT team. The goal of this program is to develop methodologies for coupling electronic health record data with a number of other data types (environmental, genetic, toxicology, pharmaceutical, other biological and socioeconomic data) to guide precision medicine and research on human disease and interactions of determinants of a wide variety of diseases and disease outcomes. Dr. Peden has also served as a site investigator on phase III pediatric asthma studies. Dr. Peden is currently PI for over $3.5 million of federally funded research from the EPA, NIAID, NIEHS, and the NHLBI, and has authored over 200 peer-reviewed publications.

In the clinic: Dr. Peden is board certified in pediatrics, allergy, and immunology and diagnostic laboratory immunology. He has seen pediatric and adult patients with asthma and a wide range of allergic and immunologic disorders at the UNC Allergy and Immunology Clinic at the North Carolina Children’s Hospital since 1992 and is listed by both Best Doctors and Top Doctors for Allergy/Immunology.

Other Experience: Dr. Peden has served as 2017-18 President of the American Academy of Allergy, Asthma, and Immunology (AAAAI), on their Board of Directors 2010-2013, and officer track 2014-2019, and is presently on the World Allergy Organization Board of Directors (2020-2023). Dr. Peden also regularly serves on NIH grant review committees and, until 2018, was a regular member of EPA advisory committees for Sulfur Oxides and Particulate Matter. He is currently the Chair of the FDA Allergenic Products Advisory Committee. He is also an Associate Editor for the Journal of Allergy and Clinical Immunology and Editor-in-Chief of Current Allergy and Asthma Reports.

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