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Sublingual Immunotherapy

Delivery of immunotherapy by the sublingual route (SLIT) continues to be used in clinical practice in many European countries, and studies are underway in the United States. The World Allergy Organization (WAO) published the first position paper on sublingual immunotherapy in 2009 to identify the indications, contraindications, and practical aspects of the treatment. (Canonica et al 2009) WAO has now completed and published the 2013 update of the position paper. (Canonica et al 2014)

Download the new Sublingual Immunotherapy Pocket Guide here!


Sublingual immunotherapy: World Allergy Organization Position Paper 2013 Update
Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M et al.  Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organization Journal 2014; 7:6 (28 March). doi:10.1186/1939-4551-7-6
Full Text

The paper presents guidelines for sublingual immunotherapy based on the World Health Organisation (WHO) model of recommendations. In addition, the document defines unmet needs as identified by analysis of recent and ongoing clinical trials in sublingual immunotherapy, and it makes recommendations for the methodology of future clinical trials worldwide.

Chairpersons Giorgio Walter Canonica, MD, Linda Cox, MD, and Ruby Pawankar, MD, PhD, led a panel of 24 authors internationally known for their expertise in sublingual immunotherapy research and clinical practice. To further ensure a global scope to the project, WAO invited its regional, national, and affiliate member societies to participate in the development of the 2009 document as well as the 2013 update.

Sublingual Immunotherapy: World Allergy Organization Position Paper 2009
Canonica GW, Bousquet J, Casale T, Lockey R, Baena-Cagnani C et al. Sublingual Immunotherapy: World Allergy Organization position paper 2009. World Allergy Organization Journal. 2009;2(11):223-281.
Full Text

The core document for consultation will remain the 2009 article, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2009". The article published in 2014 is a condensed update of ten previous chapters with the addition of new chapters on emerging issues: Practical Aspects, Perspectives and Novel Approaches, and Raising Public Awareness of Sublingual Immunotherapy. The updated chapters contain new evidences corroborated by references and revised content based on new data.

Sublingual Immunotherapy Pocket Guide
Canonica GW, Cox L, Pawankar P, eds. Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update, Pocket Guide. Published by the World Allergy Organization, 2014.

The Pocket Guide is a condensed version of the update paper, featuring key points and unmet needs, for a rapid reference to the highlights of the update paper. Readers should reference the full papers.

WAO SLIT Resources Online

Food Desensitization and SLIT, Corinne Keet, Wesley Burks, Hugh Sampson, and Ulrich Wahn, Jun. 2014, Ask the Expert

Role for SCIT, Linda Cox, Sep. 2013, Ask the Expert

Sublingual Immunotherapy for the Prevention and Management of Pediatric Asthma, Giovanni Passalacqua, Mar. 2009, AAAAI Annual Meeting, Washington DC, World Allergy Forum

Update on the Role of SLIT in Tolerance Induction to Allergens: Safety and Efficacy, Giovanni Passalacqua, Mar. 2013, AAAAI Annual Meeting, San Antonio, World Allergy Forum

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