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WAO News & Notes - June 2007
Volume 4, Issue 6

Medical Journal Review
WAO Now: What's New in the World of WAO
And In Other News . . .

For Information about WAO Travel Grants to WAC 2007 in Bangkok, click here

Visit the World Allergy Organization Exhibit Booth #9 Exterior during the LXI National Congress of Clinical Immunology and Allergy, 27-30 June 2007 in Cancun, Mexico and enter to win a free registration to the World Allergy Congress (WAC) in Bangkok, Thailand, 2-6 December 2007!

Medical Journal Reviews

Prof. Richard F. Lockey, MD, WAO Web Editor-in-Chief, and Guest Reviewer Gary Hellermann, PhD, reviewed premier medical journal articles for practicing allergists. Read Dr. Lockey’s top 3 picks below and for the other 8 reviews, click here.

Guest Reviewer: Gary Hellermann, PhD

Type 1 diabetes mellitus (DM) is one of the most common autoimmune diseases and researchers have been attempting to circumvent the immune system’s destruction of pancreatic beta cells that characterizes the disease. One promising method is by AHST. This paper reports the results of a clinical trial in which 15 newly diagnosed DM patients, age 14-31 years, were given AHST and the progress of their disease followed for up to 36 months. All but one showed marked improvement as reflected by elevated C-peptide levels and freedom from insulin use. Side effects were neutropenia, alopecia, nausea and, in one case, pneumonia that resolved with treatment. Editor’s comment: Immunointervention in type 1 DM at a young age while there is still a substantial number of beta cells appears to provide significant advantages, but long term side-effects still need to be examined. Voltarelli, JC et al. JAMA 2007; 297:1568.

The April 2007 JACI has multiple reviews and featured articles on allergen immunotherapy. The articles entitled are "Allergen Immunotherapy: Where Is It Now?," "Mechanisms of Allergen-Specific Immunotherapy," "Tradition and Innovation: Finding the Right Balance," and "Sublingual Immunotherapy: The Optimism and the Issues." In addition, there are articles entitled, "Recombinant Allergens For Immunotherapy," "Advances In Upper Airway Diseases and Allergen Immunotherapy," and "Allergic Rhinitis and Its Impact on Asthma Update: Allergen Immunotherapy." Likewise, there are three original articles on immunotherapy which include "Sublingual Immunotherapy With Grass Pollen Is Not Effective In Symptomatic Youngsters In Primary Care," "Update On the Current Status Of Peptide Immunotherapy," and "Successful Sublingual Immunotherapy With Birch Pollen Has Limited Effects On Concomitant Food Allergy To Apple and the Immune Response To the Bet v 1 homolog Mal d 1." Editor’s comment: This issue contains a multitude of articles on allergen immunotherapy and is must reading for the practicing allergist/immunologist. Nelson HS; Akdis M, et al; Durham SR; Pajno GB; Valenta R, et al; Nelson HS; Passalacqua G, et al; Röder E, et al; Larché M; Kinaciyan T, et al. JACI 2007; 119(4).

42 patients were randomized to receive single doses of I (50, 100, 200 and 400 μg) or placebo (P) via a hydrofluoroalkane pressurized metered-dose inhaler in a double-blind crossover study. Using primary efficacy comparisons, the mean percentage increases in FEV1 from placebo (P) and I, 200 and 400 μg, were 7.6 and 14.9%, respectively, at 30 min and 7.5% and 10.4%, respectively, at 21 h post-dose. At these doses, changes in mean FEV1 of I vs. P were significant from 5 min to 24 h, inclusive. I at 400 μg was statistically superior (P < 0.05) to other I doses at most time points. The highest mean differences in FEV1 of I from P were reached at 2-3 h post-dose. Once daily I (200 and 400 μg) provides 24-h bronchodilation, rapid onset, and good tolerability and safety.Editor’s comment: 24-h long-acting bronchodilators are on their way. Beeh KM, et al. Eur Respir J 2007; 29:871.

To read the additional reviews, click here.

WAO Now: What's New in the World of WAO

allergic disease resource centerNew Synopsis Available - Vasculitis
Vasculitis syndromes are a clinical concern for allergists and clinical immunologists who are likely to be involved in managing hypersensitivity vasculitis; ANCA associated vasculitis, including Wegener’s granulomatosis and Churg-Strauss vasculitis (allergic angitis and granulomatosis); and temporal arteritis. To read an update about the diagnosis and management of these difficult conditions in a new synopsis authored by international expert Dr. Dennis Ledford of Tampa, USA, click here.

WAO’s Specific Immunotherapy Document
The World Allergy Organization (WAO) convened a group of experts to provide guidelines for the methodology of future immunotherapy studies to ensure that patients are treated based on sound scientific evidence and to minimize the risk of misusing limited financial resources for scientific studies. The document summarizes the recommendations for study design, patient selection, appropriate outcomes and statistical treatment to be used in planning and performing clinical trials with specific immunotherapy.

The document was recently published in the March 2007 Issue of Allergy: European Journal of Allergy and Clinical Immunology and is now available to you free from PubMed.

You may also access the document from WAO’s Allergic Disease Resource Center.

WAO Conversations
We have the pleasure of announcing two new interviews with well-respected allergists. Take a moment to listen to them share their extensive knowledge.

Ask the Expert – Exclusive Benefit to WAO Members
Ask the Expert
is a new online tool available exclusively to WAO Members. Directed by Professors Cassim Motala and Ruby Pawankar, this online service provides the opportunity to pose educational, scientific and medical questions about allergy, asthma, and clinical immunology to one of the many WAO volunteer experts located throughout the world. We invite all WAO Members to become a part of this online service. To Ask the Expert, click here.

Call for Applications

Short-Term Research Fellowship 2007 Applications
The World Allergy Organization (WAO) offers three Short-Term Research Fellowships, to commence in the latter half of 2007, to support junior allergists to visit a center of their choice to learn a research technique. The expected duration of each attachment is 2-3 weeks. WAO will contribute up to a maximum of $2,500 USD, to include travel and accommodations, for each Short-Term Fellowship.

Priority will be given to junior clinicians within five years of award of the most recent professional degree, who are specializing in allergy and who are affiliated to an academic department or clinical institute. Applicants must be current members of a WAO member society.

The Short-Term Fellowships will be applied to a project which meets one of the WAO Research Priorities:

    • Genetic factors involved in the development of allergic disease and response to treatment
    • Allergen characterization and standardization
    • Clinical and basic studies in allergy and asthma

Application forms may be downloaded here

Applications must be received by WAO Secretariat no later than 29 June 2007

Long-Term Research Fellowship
The World Allergy Organization (WAO) offers one Long-Term Research Fellowship, to commence in 2008. The Fellowship will support a junior allergist following an approved research program at a WAO proposed host center for up to two years. WAO will contribute a monthly stipend of $1,700 US and once-yearly travel expenses between the home country and the host center.

Priority will be given to junior clinicians within five years of award of the most recent professional degree, who are specializing in allergy and who are affiliated with an academic department or clinical institute. Applicants must be active members of a WAO member society.

The Long-Term Fellowship will be applied to a project which meets one of the WAO Research Priorities:

    • Genetic factors involved in the development of allergic disease and response to treatment
    • Allergen characterization and standardization
    • Clinical and basic studies in allergy and asthma

Application forms including a list of host centers may be downloaded here

Applications must be received by WAO Secretariat no later than 30 September 2007

The WAO Henning Løwenstein Research Award 2007

The WAO Henning Løwenstein Research Award is a biennial award given to a young scientist who has shown excellence within the field of allergy. WAO and ALK-Abelló will present the award at the World Allergy Congress in Bangkok, 2-6 December 2007.

The winner will receive EURO 20,000 together with a travel grant to attend the World Allergy Congress.

alk-abelloFor application guidelines, visit www.alk-abello.com and click on "The WAO Henning Løwenstein Research Award."
Deadline: 30 June 2007

World Allergy Congress (WAC) Travel Grants
WAO, in partnership with Schering-Plough Corporation (SPC), the European Academy of Allergology and Clinical Immunology (EAACI), and the American Academy of Allergy, Asthma and Immunology (AAAAI), is sponsoring Travel Grants for young scientists to attend WAO’s World Allergy Congress (WAC) in Bangkok, Thailand, 2-6 December 2007. For further information, click here.
Deadline: 5 July 2007

You are invited to attend…

gloriaGLORIA Placements
British Society for Allergy and Clinical Immunology
2-4 July 2007
Loughborough, United Kingdom
International GLORIA Faculty:
Allen P. Kaplan
Module 7: Angioedema

XV Mexican National Congress of Pediatric Allergy and Asthma
21-25 July 2007
Merida, Yuc., Mexico
International GLORIA Faculty:
Bob Q. Lanier
Module 6: Food Allergy
Module 8: Anaphylaxis

International GLORIA is supported through unrestricted educational grants from:
dyax & genzyme
nutricia shs international

seminars and conferencesSeminars & Conferences Placement
Mexican National Congress on Clinical Immunology and Allergy
27-30 June 2007
Cancun, Mexico
WAO Invited Lecturer: Jay Portnoy

esp latin america
Emerging Societies Meeting - Cancun, Mexico
WAO's first Emerging Societies Meeting (ESM) of 2007 will take place during the LXI National Congress of Clinical Immunology and Allergy, 27-30 June 2007 in Cancun, Mexico. The ESM is a follow-up to the ESM held in Latin America in 2006 and will include representatives from Honduras, Guatemala, Cuba, El Salvador, Nicaragua and Martinique. This meeting is jointly funded by the American College of Allergy, Asthma and Immunology, the Mexican College of Allergy, Asthma and Clinical Immunology and the World Allergy Organization.

For more information on the Mexican College of Allergy, Asthma and Clinical Immunology’s meeting 27-30 June 2007, please click here.

Sign up for Online Journal Subscription -
WAO and Hogrefe & Huber Publishers are offering a limited number of free online subscriptions to Allergy & Clinical Immunology International - Journal of the World Allergy Organization for members in developing countries. If you are interested in receiving a complimentary, online subscription, please send an e-mail to info@worldallergy.org, noting "Free Journal Subscription" in the subject line, with the following details:

First name
Last (Family) name
Postal address
City, State/Province and postal code
E-mail address
Name of Member Society

And In Other News

Two Allergy Book Reviews

Mayo Clinic Atlas of Immunofluorescence in Dermatology: Patterns and Target Antigens
By: Amer N Kalaaji

Price: $98.95 USD
Available from: Mayo Clinic Scientific Press

Andrew Bagg, MD
Division of Allergy and Immunology
University of South Florida College of Medicine, Tampa Florida

This Atlas reviews immunofluorescence patterns found in many dermatologic conditions. The direct and indirect immunofluorescence findings and the target antigens are summarized in bullet point format.

The purpose is to provide information to aid in the understanding of the patterns found in immunodermatology. It is designed to present the reader with a review of clinical dermatological diseases and a summary of immunofluorescence findings to facilitate learning and memory recall. It is a valuable resource for those preparing for boards and anyone interpreting immunofluorescence results.

The Atlas targets dermatologists, pathologists, residents, and fellows. It should be used by those preparing for boards and physicians who need to interpret immunofluorescence results to diagnose and treat patients.

The 75 pages cover the major diseases in immunodermatology. Particular attention is given to staining patterns with numerous color photographs on every other page. For each disease there are clinical and direct and indirect immunofluorescence findings and target antigens summarized in an easy-to-follow bullet point format.

The color photographs and informative summaries found in the Atlas provide the student with an understanding of dermatologic immunofluorescence. This book is an excellent resource for review and a convenient visual guide for diseases in immunodermatology.

The Year in Allergy, Volume 3

Editors: S. Hasan Arshad, Stephen T. Holgate

ISBN:1 904392 60 1

List Price: $99.95 USD
Available from: Atlas Medical Publishing

Steven L. Cole, DO
Division of Allergy and Immunology
University of South Florida College of Medicine

This is the third installment of The Year in Allergy series and reviews the most recent research findings over the last two years. Each study reviewed is followed by a discussion of the scientific and clinical relevance of the findings.

The purpose of this book is to provide an overview of the major discoveries in the preceding two years relating to the mechanism, diagnosis, and treatment of allergic disorders. The book is divided into three parts, Epidemiology and Genetics (Part I), Pathophysiology and Diseases (Part II), and Treatment Modalities for Allergic Diseases (Part III).

The target audience includes researchers and clinicians from a wide array of interests in allergic disorders including specialists in allergy and immunology, dermatology, and pulmonology. Experts in these subjects will glean valuable insight into not only their own interests, but also develop potential links to related topics as well.

Each chapter includes an introduction which highlights the salient issues of the subject matter. The original publication reference is provided, and a summary of the methods is included for each paper. All studies reviewed contain an interpretation by the authors that focus on key findings and point out potential weaknesses of the information. Future directions are also discussed within the comments and conclusions section of each chapter.

This is an ever-evolving discipline with numerous papers published each month from a wide array of journals, making it difficult for clinicians and researchers to read and digest all of them in a timely manner. This book succeeds in raising awareness of recent developments in the field of allergy, and it is organized in a manner that holds interest to a diverse group of readers. Clinicians can quickly review subject material directly pertaining to patient care, and researchers have access to critical reviews of the major findings in their field of interest. Although it is impossible to analyze every publication the world has to offer in allergic disorders, the authors of this book have done a tremendous job in the emphasis of papers with the most potential to impact the field.

Find more allergy book reviews on the WAO Website here.

WAO's mission is to be a global resource and advocate in the field of allergy, advancing excellence in clinical care through education, research and training as a world-wide alliance of allergy and clinical immunology societies. Visit us on the Web at www.worldallergy.org

World Allergy Organization (WAO)
555 E. Wells Street, Suite 1100
Milwaukee, WI 53202-3823
Email: info@worldallergy.org

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Made possible through an unrestricted educational grant from Novartis.