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Archives: Medical Journal Reviews

WAO Reviews - Editors' Choice

Posted: February 2012

Articles are selected for their importance to clinicians who care for patients with asthma and allergic/immunologic diseases by Juan Carlos Ivancevich, MD, WAO Web Editor-in-Chief, and Phillip Lieberman, MD, WAO Reviews Editor.

1. Natural exposure to pollen during an individual's allergy season leads to both nasal and sinus inflammation.

Baroody FM, Mucha SM, deTineo M, Naclerio RM. Evidence of maxillary sinus inflammation in seasonal allergic rhinitis. Otolaryngology - Head and Neck Surgery. 1 February 2012 [Epub ahead of print] (doi: 10.1177/0194599811435972).


Editor's comment: Allergic rhinitis has been frequently associated with both acute and chronic sinusitis. Now the authors present the first evidence of the development of both nasal and sinus inflammation during an allergy season strengthening the association between allergic rhinitis and sinusitis.

2. Allergen immunotherapy studies show increased clinical efficacy in highly symptomatic patients vs those with less severe disease.

Howarth P, Malling HJ, Molimard M. Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients. Allergy 2012; 67(3): 321-3217.


Editor's comment: The authors have designed a novel method to evaluate the efficacy of specific allergen immunotherapy in seasonal allergic rhinitis, and advise its use in future studies on efficacy of immunotherapy.

3. European Society for Immunodeficiencies internet-based database: Common variable immunodeficiency represents the most common entity followed by selective immunoglobulin A deficiency.

Gathmann B, Binder N, Ehl S, Kindle G, the ESID Registry Working Party. The European internet-based patient and research database for primary immunodeficiencies: update 2011. Clinical & Experimental Immunology 2012; 167(3): 479-491.


Editor's comment: Since 2004, the European Society for Immunodeficiencies has managed a pan-European registry for primary immunodeficiencies, used as a data collection platform by several national registries, including France, The Netherlands, Germany, Switzerland, Austria and the Czech Republic. This article details some of their findings.

4. Increased body mass index among young asthmatics is associated with increased consumption of steroids and emergency room visits.

Black MH, Smith N, Porter AH, Jacobsen SJ, Koebnick C. Higher prevalence of obesity among children with asthma. Obesity Advance online publication, 17 January 2012.

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Editor’s comment: In this large, population-based cross-sectional study, being overweight, or having moderate obesity, or extreme obesity, were associated with an increased frequency of asthma with variations according to race and ethnicity.

5. Supplementation of an extensively hydrolyzed casein formula with Lactobacillus GG affects the development of cow milk tolerance in infants.

Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: A randomized trial. The Journal of Allergy and Clinical Immunology 2012; 129(2): 580-582.

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Editor’s comment: Supplementation of an extensively hydrolyzed casein formula with Lactobacillus GG accelerated the development of tolerance in infants to Cow Milk Protein. All patients consumed regular doses of cow's milk daily without showing any signs or symptoms related to cow milk allergy for 6 months after the negative DBPCFC result, a finding suggesting the persistence of tolerance.

6. The relationship between innate immunity and chronic rhinosinusitis.

van Drunen CM, Mj÷sberg JM, Segboer CL, Cornet ME, Fokkens WJ. Role of innate immunity in the pathogenesis of chronic rhinosinusitis: Progress and new avenues. Current Allergy and Asthma Reports 5 February 2012 (doi: 10.1007/s11882-012-0249-4).

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Editor’s comment: Excellent review that updates our knowledge about the immune pathophysiology of chronic rhinosinusitis and positions the innate immunity as an important factor in the development of this condition, which should be viewed as a single disease.

7. Mechanisms of oral tolerance.

Pabst O and Mowat AM. Oral tolerance to food protein. Mucosal Immunology Advance online publication, 8 February 2012-02-16 (doi:10.1038/mi.2012.4)

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Editor’s comment: Interesting and comprehensive review that updates the knowledge about the anatomical basis of antigen uptake and recognition in oral tolerance and highlights possible mechanisms underlying the immunosuppression.

8. Association between atopic dermatitis and contact sensitization.

Thyssen JP, Linneberg A, Engkilde K, MennÚ T, Johansen JD. Contact sensitization to common haptens is associated with atopic dermatitis: New insight. British Journal of Dermatology 2012; Accepted article (doi: 10.1111/j.1365-2133.2012.10852.x).


Editor’s comment: Contact sensitization was strongly associated with atopic dermatitis in adults from a general population in Denmark. The association was similar in individuals with and without filaggrin mutations. The higher prevalence of contact sensitization was mainly driven by fragrance chemicals.

9. IgG4-related disease has been described in virtually every organ system.

Stone JH, Zen Y and Deshpande V. IgG4-related disease. New England Journal of Medicine 2012; 366(6): 539-551.


Editor’s comment: A specific and comprehensive review of IgG4-Related Disease. It discusses the IgG4 molecule and the epidemiology, pathology, and clinical presentation of this condition. Laboratory, imaging findings and treatment are also reviewed.

10. Relationship between the Gln27Glu and Arg16Gly alleles of the β2-adrenergic receptor gene with susceptibility, severity of asthma, and treatment response in mestizo schoolchildren.

Isaza C, Sep˙lveda-Arias JC, Agudelo BI, Arciniegas W, Henao J et al. β2-adrenoreceptor polymorphisms in asthmatic and non-asthmatic schoolchildren from Colombia and their relationship to treatment response. Pediatric Pulmonology 2012; published online before print (doi: 10.1002/ppul.22521)


Editor’s comment: The gene expression analysis suggests that genetic variability at sites 16 and 27 of the β2-adrenoreceptor is not associated with differences in the expression of the ADRB2 gene, which is known to be one of the genes trans-activated by glucocorticoids suggesting that the Arg16Gly and Gln27Glu alleles are not involved in the therapeutic response of asthmatic patients to glucocorticoids in Colombian Mestizo volunteers.

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