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Archives: Medical Journal Reviews

WAO Reviews - Editors' Choice

Posted: August 2013

Articles are selected for their importance to clinicians who care for patients with asthma and allergic/immunologic diseases by Juan Carlos Ivancevich, MD, WAO Web Editor-in-Chief, and Phillip Lieberman, MD, WAO Reviews Editor.

1. Genetic relationship between atopic dermatitis (AD), asthma, allergic rhinitis (AR) and psoriasis.

Weidinger S, Willis-Owen SAG, Kamatani Y, Baurecht H, Morar N et al. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Human Molecular Genetics 2013; Corrected Proof July 25. doi:10.1093/hmg/ddt317

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Editor’s comment: The authors present a genome-wide association study of childhood-onset AD in 1,563 European cases with known asthma status and 4,054 European controls. They found considerable overlap between AD and psoriasis together with variable coincidence between AR and asthma.

2. Co-factors play a fundamental role in anaphylaxis.

Wölbing F, Fischer J, Köberle M, Kaesler S, Biedermann T. About the role and underlying mechanisms of cofactors in anaphylaxis. Allergy 2013; Published online before print, 2 August. doi:10.1111/all.12193

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Editor’s comment: In this excellent review the authors aim to update clinicians and clinical scientists about conditions that modulate the onset of anaphylaxis. They found that exercise, alcohol consumption and NSAID administration increases skin prick test reactivity to and bioavailability of the allergen, and infectious disease modulates the cellular activation threshold.

3. Understanding mechanisms of chronic itch to develop effective treatments.

Tominaga M, Takamori K. An update on peripheral mechanisms and treatments of itch. Biological and Pharmaceutical Bulletin 2013; 36(8): 1241-1247.

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Editor’s comment: This review highlights recent knowledge regarding epidermal nerve fibers that are partly involved in itch sensitization, and discusses peripheral mechanisms and treatments of itch, especially in atopic dermatitis.

4. MP29-02 more effective than commercially available active comparators in seasonal allergic rhinitis.

Meltzer E, Ratner P, Bachert C, Carr W, Berger W et al. Clinically relevant effect of a new intranasal therapy (MP29-02) in allergic rhinitis assessed by responder analysis. International Archives of Allergy and Immunology 2013; 161(4): 369-377.

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Editor’s comment: In this post hoc analysis using a novel efficacy analyses, the authors concluded that MP29-02, a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), provided faster and more complete symptom control than commercially available FP, AZE and placebo in seasonal allergic rhinitis patients.

5. Hymenoptera venom allergy quality of life in children and adolescents.

Cichocka-Jarosz E, Brzyski P, Tobiasz-Adamczyk B, Lis G, Pietrzyk JJ. Development of children's hymenoptera venom allergy quality of life scale (CHVAQoLS). Clinical and Translational Allergy 2013; 3:35. doi:10.1186/2045-7022-3-25

Provisional Abstract (Provisional PDF available)

Editor’s comment: The presented scale comprises high validity and reliability subscales measuring six dimensions of HRQoL related to Hymenoptera venom allergy in children and adolescents.

6. Vitamins or nutrients acting as methyl donors to prevent or treat asthma.

Han Y-Y, Blatter J, Brehm JM, Forno E, Litonjua AA, Celedon JC. Diet and asthma: vitamins and methyl donors. The Lancet Respiratory Medicine 2013; Published online before print 31 July. Doi:10.1016/S2213-2600(13)70126-70127.


Editor’s comment: In this review the authors examine evidence of a link between two groups of dietary components that have been extensively studied in connection with asthma: vitamins (A, C, D, and E) and nutrients acting as methyl donors (folate, vitamin B12, and choline). They concluded that at present insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.

7. Anti-IgE therapy modulates the allergen-specific responses in young patients with severe refractory atopic dermatitis (AD).

Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D et al. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: A randomized, placebo-controlled clinical trial. International Archives of Allergy and Immunology 2013; 162(1): 89-93. doi:10.1159/000350486


Editor’s comment: In this randomized, double-blind, placebo-controlled study of 8 young patients with severe refractory AD, the authors concluded that omalizumab decreases levels of cytokines involved in Th2 polarization and allergic inflammation, including TSLP, TARC and OX40L and improves clinical outcomes measured by SCORAD; however, these effects were comparable to improvements in the control group.

8. Underlying pathogenesis of atopic eczema (AE).

Eyerich K, Novak N. Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy 2013;  Published online before print 29 July. doi:10.1111/all.12184

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Editor’s comment: In this review the authors piece together the current understanding of immune as well as barrier abnormalities into the pathogenesis mosaic of AE.

9. Biochemical features associated with secretory IgA (SIgA).

Corthésy B. Multi-faceted functions of secretory IgA at mucosal surfaces. Frontiers in Immunology 2013; 4:00187. doi:10.3389/fimmu.2013.00185

Full Text, Open Access

Editor’s comment: The author concludes in this excellent review that SIgA plays a crucial role in the essential communication occurring between the host’s mucosal environment and the proper sensing of harmless inhabitants or noxious pathogens/antigens.

10. Mathematical model of asthma development.

Kim Y, Lee S,  Kim Y-S, Lawler S, Gho YS et al. Regulation of Th1/Th2 cells in asthma development: A mathematical model. Mathematical Biosciences and Engineering 2013; 10(4): 1095-1133.

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Editor’s comment: The present paper develops a mathematical model of asthma development which focuses on the relative balance of Th1 and Th2 cell induced asthma, representing the complex network of interactions between cells and molecules.

11. Allergic inflammation influences the immunity against infections.

Rantala A, Jaakkola JJK, Jaakkola MS. Respiratory infections in adults with atopic disease and IgE antibodies to common aeroallergens. PLoS ONE 2013; 8(7): e68582. doi:10.1371/journal.pone.0068582

Full Text, Open Access

Editor’s comment: This population-based cross-sectional study of 1,008 atopic and non-atopic adults 21–63 years old provides new evidence that working-aged adults with atopic disease experience significantly more lower respiratory tract infections and upper respiratory tract infections than non-atopics.

12. Computerized physician order entry (CPOE) systems to reduce the medical error rates.

Peikari HR, Zakaria MS, Yasin NM, Shah MH, Abdelbary E. Role of computerized physician order entry usability in the reduction of prescribing errors. Healthcare Informatics Research 2013; 19(02): 93-101.

Full Text PDF, Open Access

Editor’s comment: This research examined the impacts of usability of CPOE systems on the reduction of doctors' prescribing errors and concluded that prescribing errors in terms of drug allergy, drug interaction, and drug dosing errors, are reduced if the CPOE is not error-prone and easy to use, if the user interface is consistent, and if it provides quality information to doctors.

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