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KK Women’s and Children’s Hospital and Translational Immunology Institute (Singapore)

KK Women’s and Children’s Hospital and Translational Immunology Institute

KK Women’s and Children’s Hospital (KKH), founded in 1858, is Singapore’s largest tertiary referral centre for obstetrics, gynaecology, paediatrics and neonatology. At KKH, we aim to lead in excellent, holistic and compassionate care for women and children. Our centre’s multidisciplinary team consisting of paediatric allergists, pulmonologists, immunologists, gastroenterologists, dermatologists, allergy specialist nurses and dietitians, work closely to deliver high quality and value care to patients with allergic diseases, difficult asthma and immunodeficiency disorders. Our centre believes strongly in patient advocacy and conducts regular workshops for school teachers, to raise awareness of food allergy and safety in schools, including the training in use of adrenaline auto-injectors. As an Academic Medical Centre, KKH believes that world-class clinical training and research are imperative in raising the standard of care. Hence, the hospital has adopted a culture of innovation as it achieves world-class clinical leadership. KKH is a major teaching hospital for Duke-NUS Graduate Medical School, Yong Loo Lin School of Medicine and Lee Kong Chian School of Medicine. The hospital also runs the largest specialist training programme for Obstetrics and Gynaecology, and Paediatrics in Singapore. Both programmes are highly rated for the high quality of clinical teaching and the commitment to translational research. In 2021, the hospital launched the SingHealth Duke-NUS Maternal and Child Health Research Institute (MCHRI), which aims to support the growth of every woman and child to their fullest potential through research and innovation, to transform national heath in Singapore and the region.

Translational Immunology Institute (TII) is a Joint Research Institute established under the auspices of SingHealth and Duke-NUS. At TII, we aim to address the knowledge gap between basic scientists, clinical practitioners and industry to foster truly translational research with meaningful outcomes for society. We undertake translational clinical research in immunology over a range of focus areas of human health and disease. We use an agile and powerful technology workflow, brought together by a robust infrastructure and resources. TII has been designed from the offset in an exquisitely translational, multidimensional way. It relies on a very strong technology platform, which includes several high dimensionality approaches, including among others mass cytometry (Cytof), multiplexed tissue analyses and single cell transcriptomics. These technologies are integrated into a single work flow, thus enabling evolution from phenotype to mechanism. TII acts as an interface between technologies and unmet needs. As such, it has direct and preferential access to well characterised clinical samples from the Singapore health system. TII is very active in promoting and teaching Translational Medicine and is fully integrated with initiatives such as Eureka Institute for Translational Medicine, as well as running the Duke-NUS Masters in International Translational Medicine. Our research spans projects that define health in immunological terms, understand Immune modulation in health and disease, identify disease mechanisms and validate clinical biomarkers. TII has demonstrated scientific productivity across immune and inflammation based human disease areas. Since its establishment in 2013, the centre has published research outcomes in several prestigious peer reviewed international journals including Cell, Immunity, Science, Nature, Nature Rheumatology, Nature Biotechnology, Nature Communications, Gastroenterology, Gut, JCI insight etc. to a cumulative Impact Factor of 1517.716 and growing.

In line with the World Allergy Organization’s mission, KKH and TII will join hands in intensifying and accelerating multidisciplinary scientific and clinical innovation, education and advocacy, in order to enhance the knowledge of allergy and clinical immunology for physicians, nurses, allied health professionals, our patients and families.


Our Center Directors:

Dr. Kok Wee Chong
Head and Senior Consultant
Allergy Service

Dr. Biju Thomas
Head and Senior Consultant
Respiratory Medicine Service

Associate Professor Thaschaweek Arkachairi
Head and Senior Consultant
Rheumatology and Immunology Service

Professor Salvatore Albani
Translational Immunology Institute


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