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The Center for Allergy, Immunology and Pediatric Pneumology at Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Milan, Italy)

The Center for Allergy, Immunology, and Pediatric Penumology
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milanis

The Center for Allergy, Immunology and Pediatric Pneumology at Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milanis one of Milan’s leading Allergy centers. Dr. Daniele Giovanni Ghiglioni is the Coordinator of the Center, where he leads a group of pediatric specialists. The Center is transversal through all the Pediatric Units (ER Unit, Chronic and Acute disease Units).

The Center is specialized in diagnosis and treatment of allergic, immunologic and lung diseases in children, including Vernal Keratoconjunctivitis (VKC).

The Center carries out pediatric allergy consultations and collaborates with other pediatric and non-pediatric services:

  1. pediatric pneumology, immunology, gastroenterology with endoscopy and infectious disease,
  2. pediatric ophthalmology, endocrinology,
  3. pediatric Respiratory Pathophysiology service,
  4. pediatric Cystic Fibrosis,
  5. Allergy Clinic of the General Medicine Unit - Immunology and Allergology (adults),
  6. Professional Allergy Unit of the Occupational Medicine Unit.


The Center for Allergy, Immunology and Pediatric Pneumology is a state-of-the art facility, occupying 600 sq. meters and including a pulmonary function laboratory, an allergy testing room, a treatment area with resuscitation equipment, 5 consulting rooms, 1 room for dietitians, 1 slit lamp room, a clinical coordinator’s office, a conference room, and a waiting room-play area.

A research laboratory provides the necessary equipment to carry out the studies managed at the Center, whereas a pharmacy prepares galenic drugs (cyclosporine and tacrolimus eyedrops) for Vernal Keratoconjunctivitis patients.

Clinical activities

The Center treats patients with a broad spectrum of allergic and immunologic diseases including food allergies, allergic rhinitis, asthma, atopic and contact dermatitis, chronic urticaria and angioedema, and primary immunodeficiencies. Patients with lung diseases other than asthma, such as recurrent pneumonias, stridor, congenital thoracic malformations, bronchiectasis, chronic pulmonary diseases, also needing ventilation, primary ciliary dyskinesia, Cystic fibrosis are also treated. Tests and procedures routinely performed include allergy skin prick tests, intradermal tests, allergen immunotherapy, oral food challenges, and all the possible lung function tests, according to patients’ age.

Vernal Keratoconjunctivitis

The Center is one of the few in Italy to treat patients with VKC.  Although generally self-limiting, VKC can cause serious complications: eyelid scars, eyelid adhesions, punctate keratitis, corneal ulcers etc. In order to shorten the time to diagnosis and to better adjust therapy, we have organized a multidisciplinary team of pediatricians, allergists and ophtalmologists, working with the hospital pharmacy to provide a complete diagnostic-therapeutic pathway for more than 500/1000 patients and their families.


Alongside patient treatment, scientific activity plays a pivotal role. There are multiple ongoing research projects at any given time. Research enables continuous quality improvement in patient care. Protocols implemented at the Center are described in scientific papers and published in ranked journals. A Clinical Trial Unit, devoted only to pediatric patients, supports this activity.

Education and training

The Center has a 5-year fellowship program in Pediatrics, approved by the Italian Ministry of Health and University of Milan – Medical School, providing residents with extensive experience in the fields of Allergy, Clinical Immunology and Pediatric Pneumology. The Center is affiliated with University of Milan – Medical School and takes part in the education of medical students in the fields of Allergy, Clinical Immunology and Pediatric Pneumology. The Center actively participates to scientific meetings of the main national and international scientific societies.


The center will strengthen its synergies within Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and other entities in the Milan Area to develop a coordinated assistance network. Leveraging on this experience, we will collaborate with national and international centers on epidemiological, clinic and diagnostic research studies, with the goal of adopting a personalized medicine approach.

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